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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Legionella pneumophila subsp. pneumophila str. Mississauga
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotationSAAS annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH2), Imidazole glycerol phosphate synthase subunit HisH (hisH1), Imidazoleglycerol-phosphate synthase (hisF4), Cyclase (hisF2), Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase, cyclase subunit HisF (hisF)
  6. Histidine biosynthesis bifunctional protein HisB (hisB)
  7. Histidinol-phosphate aminotransferase (hisC), Histidinol-phosphate aminotransferase (hisC2)
  8. Histidine biosynthesis bifunctional protein HisB (hisB)
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei124NADUniRule annotation1
Binding sitei187NADUniRule annotation1
Binding sitei210NADUniRule annotation1
Binding sitei236SubstrateUniRule annotation1
Metal bindingi258ZincUniRule annotation1
Binding sitei258SubstrateUniRule annotation1
Metal bindingi261ZincUniRule annotation1
Binding sitei261SubstrateUniRule annotation1
Active sitei325Proton acceptorUniRule annotation1
Active sitei326Proton acceptorUniRule annotation1
Binding sitei326SubstrateUniRule annotation1
Metal bindingi359ZincUniRule annotation1
Binding sitei359SubstrateUniRule annotation1
Binding sitei413SubstrateUniRule annotation1
Metal bindingi418ZincUniRule annotation1
Binding sitei418SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Histidine biosynthesisUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotationSAAS annotation, NADUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotationSAAS annotation (EC:1.1.1.23UniRule annotationSAAS annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotationImported
ORF Names:LPM_2845Imported
OrganismiLegionella pneumophila subsp. pneumophila str. MississaugaImported
Taxonomic identifieri1206778 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
Proteomesi
  • UP000188802 Componenti: Unassembled WGS sequence

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd06572 Histidinol_dh, 1 hit
HAMAPiMF_01024 HisD, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR001692 Histidinol_DH_CS
IPR022695 Histidinol_DH_monofunct
IPR012131 Hstdl_DH
PANTHERiPTHR21256 PTHR21256, 1 hit
PfamiView protein in Pfam
PF00815 Histidinol_dh, 1 hit
PIRSFiPIRSF000099 Histidinol_dh, 1 hit
PRINTSiPR00083 HOLDHDRGNASE
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00069 hisD, 1 hit
PROSITEiView protein in PROSITE
PS00611 HISOL_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1S8GEN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTIKNWQLL PENDKRRCLS RPRDNSAIQE NVLEIINQVQ LSGDKALYDL
60 70 80 90 100
TKRFDRVNLQ YLQISQEKIR QASIPQNALI AIKQAIETIS SYHQSLLPEN
110 120 130 140 150
TEISTASGIT IRNVYRPIQK VGLYVPGGNK TPLVSSLLMQ AIPAKVAGCP
160 170 180 190 200
IKVLCTPPDA EGEINEHILV AARLCGIDTI YAIGGAQAIA AMAYGTESVI
210 220 230 240 250
KVDKIFGPGN SYVTQAKTLV AIDADGAAID MPAGPSEVMI LADTEANPEF
260 270 280 290 300
IAADLLAQAE HGPDSQVILI CDECELANQV NQQLEIQMSY LSRIEFIKQS
310 320 330 340 350
LANSRIIICS NQSEQLDIIN SYAPEHLIIN RKNPEPWIEK IVAAGTVFLG
360 370 380 390 400
SWAAETMGDY VTGSNHVLPT SGFSRNHSGL STLDFMTRFT VQAINQEAIR
410 420 430
NLGPAAMTLA EIEGLDAHAN AVQIRLNTLG D
Length:431
Mass (Da):46,942
Last modified:May 10, 2017 - v1
Checksum:iAD0FE1722DB288B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ANNP01000035 Genomic DNA Translation: OOK39253.1
RefSeqiWP_011946307.1, NZ_ANNP01000035.1

Similar proteinsi

Entry informationi

Entry nameiA0A1S8GEN6_LEGPN
AccessioniPrimary (citable) accession number: A0A1S8GEN6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: March 28, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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