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Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Streptomyces pactum
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processDNA damage, DNA repairUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Gene namesi
Name:ungUniRule annotation
ORF Names:B1H29_32340Imported
OrganismiStreptomyces pactumImported
Taxonomic identifieri68249 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000189443 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 212UDGInterPro annotationAdd BLAST160

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd10027. UDG_F1. 1 hit.
Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_00148. UDG. 1 hit.
InterProiView protein in InterPro
IPR002043. UDG_fam1.
IPR018085. Ura-DNA_Glyclase_AS.
IPR005122. Uracil-DNA_glycosylase-like.
IPR036895. Uracil-DNA_glycosylase-like_sf.
PANTHERiPTHR11264. PTHR11264. 1 hit.
PfamiView protein in Pfam
PF03167. UDG. 1 hit.
SMARTiView protein in SMART
SM00986. UDG. 1 hit.
SUPFAMiSSF52141. SSF52141. 1 hit.
PROSITEiView protein in PROSITE
PS00130. U_DNA_GLYCOSYLASE. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1S6JGS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRPLHEIV EAGWAQALEP VAGRITSMGE FLRAEISAGR TYLPAGSNVL
60 70 80 90 100
RAFQQPFDDV RVLIVGQDPY PTPGHAVGLS FSVAPEVRPL PGSLVNIFRE
110 120 130 140 150
LNSDLNLPQP SNGDLTPWAR QGVLLLNRAL TTAPRKPAAH RGKGWEEVTE
160 170 180 190 200
QAIRALAARG KPMVSILWGR DARNLRPLLG DLPAVESAHP SPMSADRGFF
210 220
GSRPFSRAND LLVRLGGQPV DWRLP
Length:225
Mass (Da):24,465
Last modified:May 10, 2017 - v1
Checksum:iB00426C35CEF091F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP019724 Genomic DNA. Translation: AQS70956.1.
RefSeqiWP_055420581.1. NZ_LIQD01000004.1.

Similar proteinsi

Entry informationi

Entry nameiA0A1S6JGS3_9ACTN
AccessioniPrimary (citable) accession number: A0A1S6JGS3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: March 28, 2018
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported