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Protein
Submitted name:

Collagen type IV alpha

Gene

1280160

Organism
Anopheles gambiae (African malaria mosquito)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Collagen type IV alphaImported
Gene namesi
Name:1280160Imported
OrganismiAnopheles gambiae (African malaria mosquito)Imported
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membranePROSITE-ProRule annotation, Extracellular matrix, Secreted

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi1627 ↔ 1633PROSITE-ProRule annotation

Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.PROSITE-ProRule annotation
Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1567 – 1789Collagen IV NC1InterPro annotationAdd BLAST223

Domaini

Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain.PROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the type IV collagen family.PROSITE-ProRule annotation

Keywords - Domaini

CollagenPROSITE-ProRule annotationSAAS annotation

Family and domain databases

Gene3Di2.170.240.10. 1 hit.
InterProiView protein in InterPro
IPR008160. Collagen.
IPR001442. Collagen_IV_NC.
IPR036954. Collagen_IV_NC_sf.
IPR016187. CTDL_fold.
PfamiView protein in Pfam
PF01413. C4. 2 hits.
PF01391. Collagen. 16 hits.
SMARTiView protein in SMART
SM00111. C4. 2 hits.
SUPFAMiSSF56436. SSF56436. 2 hits.
PROSITEiView protein in PROSITE
PS51403. NC1_IV. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1S4H159-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNESRSSARL AALTIASRLV SHYLAGSLVR TTDVQFWASS NNNDNSGVGL
60 70 80 90 100
FKRQEQEYPR QLAPQIDPSY SIMDTASGPQ GPPGKNCTSG GCCLPKCFAE
110 120 130 140 150
KGNRGLPGPM GLKGAKGVRG FPGSEGLPGE KGTKGEPGPV GLQGPKGDRG
160 170 180 190 200
RDGLPGYPGI PGTNGVPGVP GAPGLAGRDG CNGTDGLPGL SGLPGNPGPR
210 220 230 240 250
GYAGIPGTKG EKGEPARHPE NYNKGQKGEP GNDGLEGLPG PQGEVGPRGF
260 270 280 290 300
PGRPGEKGVP GTPGVRGERG DKGVCIKGEK GQKGAKGEEV YGATGTTTTT
310 320 330 340 350
GPKGEKGDRG EPGEPGRSGE KGQAGDRGQV GERGHKGEKG LPGQPGPRGR
360 370 380 390 400
DGNFGPVGLP GQKGDRGSEG LHGLKGQSGP KGEPGRDGIP GQPGIAGPAG
410 420 430 440 450
APGGGEGRPG APGPKGPRGY EGPQGPKGMD GFDGEKGERG QMGPKGGQGV
460 470 480 490 500
PGRPGPEGMP GDKGDKGESG SVGMPGPQGP RGYPGQPGPE GLRGEPGQPG
510 520 530 540 550
YGIPGQKGNA GMAGFPGLKG QKGERGFKGV MGTPGDAKEG RPGAPGLPGR
560 570 580 590 600
DGEKGEPGRP GLPGAKGERG LKGELGGRCT DCRPGMKGDK GERGYAGEPG
610 620 630 640 650
RPGASGVPGE RGYPGMPGED GTPGLRGEPG PKGEPGLLGP PGPSGEPGRD
660 670 680 690 700
AEIPMDQLKP IKGDKGEKGE NGLMGIKGEK GFPGPVGPEG KMGLRGMKGD
710 720 730 740 750
KGRPGEAGID GAPGAPGKDG LPGRHGQTVK GEPGLKGNVG YSGDKGDKGY
760 770 780 790 800
SGLKGEPGRC ASIPPNLEEA IRGPPGTQGE KGAPGIQGIR GDKGEMGEQG
810 820 830 840 850
RTGMQGNAGP PGAPGPVGPR GLTGLRGEKG NTGPLGPPGA PGRDGMPGAP
860 870 880 890 900
GLPGSKGGKG DPGLSMVGPP GPKGNPGLRG PKGDRGGMGD RGDPGQPGSV
910 920 930 940 950
GYPGEKGDLG IPGQPGFPGE VGPKGEPGPK GPAGHPGAPG RPGMDGVKGL
960 970 980 990 1000
AGLKGDVGAP GVIGLPGQKG EMGQAGNDGL KGFQGRKGMM GAPGIQGVRG
1010 1020 1030 1040 1050
PQGAKGEPGE KGDRGEIGMK GLMGQTGPPG MLGPKGDKGL AGLPGPACLP
1060 1070 1080 1090 1100
GLSGEKGDKG YTGPEGPPGE PGAASEKGQK GEPGVPGLRG NDGLPGLEGP
1110 1120 1130 1140 1150
SGPKGDAGVP GYGRPGPQGE KGDVGLTGIN GLPGLNGVKG DMGVPGFPGV
1160 1170 1180 1190 1200
KGDKGTTGLP GVPGAPCMDG LPGAEGPAGP RGYDGEKGFK GEPGRIGERG
1210 1220 1230 1240 1250
ELGEKGDQGL MGPVGLMGRK GDRGVPGSPG LPATAAAIKG DKGEPGFPGA
1260 1270 1280 1290 1300
IGRPGKVGAP GLPGDMGTKG EMGIQGLPGL PGPAGLNGLP GMKGDMGPMG
1310 1320 1330 1340 1350
EKGDSCPVVK GEKGLPGRPG KMGRDGPPGL LGEKGDKGLS GLPGPMGPPG
1360 1370 1380 1390 1400
PPGPLGRQGE KGDRGDSGLM GRPGKDGLPG PQGQRGLPGP QGEKGDQGPP
1410 1420 1430 1440 1450
GFIGPKGERG ERGRDGMNGL NGPQGLKGDR GMPGLEGVAG LPGMVGEKGD
1460 1470 1480 1490 1500
RGLPGMAGLN GAPGEKGQKG ETPQLPPQRK GPPGPPGFNG PKGDKGMPGL
1510 1520 1530 1540 1550
AGPAGIPGAP GAPGEMGLRG FEGARGLQGL RGDVGPEGRP GRDGAPGLPG
1560 1570 1580 1590 1600
PKGEPGRDCE SAPYYTGILL VRHSQSDEVP MCEPGHLKLW DGYSLLYVDG
1610 1620 1630 1640 1650
NDYPHNQDLG SAGSCVRKFS TLPVLACGQN NICNYASRND RTFWLSTSAP
1660 1670 1680 1690 1700
IPMMPVTENE MRPYISRCTV CEAPTNVIAV HSQTLHIPEC PNGWDGLWIG
1710 1720 1730 1740 1750
YSFLMHTAVG HGGGGQSLSG PGSCLEDFRA TPFIECNGGK GHCHYYETQT
1760 1770 1780
SFWLVSLEDH QQFQRPEQQT LKAGNLLSRV SRCQVCIRR
Length:1,789
Mass (Da):177,306
Last modified:April 12, 2017 - v1
Checksum:iD465FB9AAF742D6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008984 Genomic DNA. No translation available.

Genome annotation databases

EnsemblMetazoaiAGAP009200-RA; AGAP009200-PA; AGAP009200.
VectorBaseiAGAP009200-RA; AGAP009200-PA; AGAP009200.

Similar proteinsi

Entry informationi

Entry nameiA0A1S4H159_ANOGA
AccessioniPrimary (citable) accession number: A0A1S4H159
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: February 28, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation