Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

LOC107805957

Organism
Nicotiana tabacum (Common tobacco)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (LOC107828938), Glucose-6-phosphate 1-dehydrogenase (LOC107822069), Glucose-6-phosphate 1-dehydrogenase, Glucose-6-phosphate 1-dehydrogenase, Glucose-6-phosphate 1-dehydrogenase, Glucose-6-phosphate 1-dehydrogenase, chloroplastic, Glucose-6-phosphate 1-dehydrogenase (LOC107794892), Glucose-6-phosphate 1-dehydrogenase (LOC107805957), Glucose-6-phosphate 1-dehydrogenase (LOC107758909), Glucose-6-phosphate 1-dehydrogenase (LOC107831534), Glucose-6-phosphate 1-dehydrogenase (G6PDHP2), Glucose-6-phosphate 1-dehydrogenase (LOC107805957), Glucose-6-phosphate 1-dehydrogenase (LOC107786177), Glucose-6-phosphate 1-dehydrogenase (LOC107828938)
  2. no protein annotated in this organism
  3. 6-phosphogluconate dehydrogenase, decarboxylating (LOC107791333), 6-phosphogluconate dehydrogenase, decarboxylating (LOC107777046), 6-phosphogluconate dehydrogenase, decarboxylating (LOC107799009), 6-phosphogluconate dehydrogenase, decarboxylating (LOC107789656), 6-phosphogluconate dehydrogenase, decarboxylating (LOC107779182)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processCarbohydrate metabolism, Glucose metabolismUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Gene namesi
Name:LOC107805957Imported
OrganismiNicotiana tabacum (Common tobacco)Imported
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana
Proteomesi
  • UP000084051 Componenti: Genome assembly

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini122 – 300G6PD_NInterPro annotationAdd BLAST179
Domaini303 – 587G6PD_CInterPro annotationAdd BLAST285

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

KOiK00036.

Family and domain databases

HAMAPiMF_00966. G6PD. 1 hit.
InterProiView protein in InterPro
IPR001282. G6P_DH.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiView protein in Pfam
PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00871. zwf. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1S4B9F0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASHLSVSLS TSSSETSIFP STNRKLAVLP TAVRTFPILS KGRTIKKTRT
60 70 80 90 100
QMINVAHVQP PEVNRPHCSI RSTSFNVKGT GSTTSLDEEV KVDASGMEVS
110 120 130 140 150
IKLSLSSTDA ETDDSASLSI AVIGATGLLA RTKIFPALFA LYYSGHLPEK
160 170 180 190 200
FGIFGYSRKN LTEDHLRAII APTLSCRIDH QENCEEKMDA FLKRIFYLNG
210 220 230 240 250
GYDNREGMSN LNTLMEEAEG KFGANRIFYL SVPQEALIDV ASSLAEMAQT
260 270 280 290 300
QRGWNRVIIE KPFGLGLFSS HQLTTSLLSD FEEKQLYRID HLLGRNTIEN
310 320 330 340 350
LAVLRFSNLV FMPLWNRSYI HNIQVTFSEE LGMQTSARYP NGYGILGDVV
360 370 380 390 400
HSHIFQTVAL LAMEPPVTLD GEDIRYEKVK VLKSIRKLES SDVILGHYEA
410 420 430 440 450
DSGSNFKDKD NPMPTYFGAV LYVDNARWDS VPFLINAGRG LKKNRVEIRI
460 470 480 490 500
QFRRVPGNLY NKDGGHMQNL ATNELILRDV PDEAILVRIN NKIPGLGMNL
510 520 530 540 550
EASELNLLYK DKYNVEITDS YEQLLHDVID GDNHLFMRSD EVEAAWNILS
560 570 580 590
PVLSELDNNN VTLERYNFGS KGPDKAVNLW AKHGVQWLDD
Length:590
Mass (Da):66,173
Last modified:April 12, 2017 - v1
Checksum:i79DE4BF80F2F584C
GO

Sequence databases

RefSeqiXP_016485550.1. XM_016630064.1.

Genome annotation databases

GeneIDi107805957.
KEGGinta:107805957.

Similar proteinsi

Entry informationi

Entry nameiA0A1S4B9F0_TOBAC
AccessioniPrimary (citable) accession number: A0A1S4B9F0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: October 25, 2017
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported