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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

LOC107794892

Organism
Nicotiana tabacum (Common tobacco)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (LOC107828938), Glucose-6-phosphate 1-dehydrogenase (LOC107822069), Glucose-6-phosphate 1-dehydrogenase, Glucose-6-phosphate 1-dehydrogenase, Glucose-6-phosphate 1-dehydrogenase, Glucose-6-phosphate 1-dehydrogenase, chloroplastic, Glucose-6-phosphate 1-dehydrogenase (LOC107794892), Glucose-6-phosphate 1-dehydrogenase (LOC107805957), Glucose-6-phosphate 1-dehydrogenase (LOC107758909), Glucose-6-phosphate 1-dehydrogenase (LOC107831534), Glucose-6-phosphate 1-dehydrogenase (G6PDHP2), Glucose-6-phosphate 1-dehydrogenase (LOC107805957), Glucose-6-phosphate 1-dehydrogenase (LOC107786177), Glucose-6-phosphate 1-dehydrogenase (LOC107828938)
  2. no protein annotated in this organism
  3. 6-phosphogluconate dehydrogenase, decarboxylating (LOC107791333), 6-phosphogluconate dehydrogenase, decarboxylating (LOC107777046), 6-phosphogluconate dehydrogenase, decarboxylating (LOC107799009), 6-phosphogluconate dehydrogenase, decarboxylating (LOC107789656), 6-phosphogluconate dehydrogenase, decarboxylating (LOC107779182)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processCarbohydrate metabolism, Glucose metabolismUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Gene namesi
Name:LOC107794892Imported
OrganismiNicotiana tabacum (Common tobacco)Imported
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana
Proteomesi
  • UP000084051 Componenti: Genome assembly

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini106 – 284G6PD_NInterPro annotationAdd BLAST179
Domaini287 – 581G6PD_CInterPro annotationAdd BLAST295

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Family and domain databases

HAMAPiMF_00966. G6PD. 1 hit.
InterProiView protein in InterPro
IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiView protein in Pfam
PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiView protein in PROSITE
PS00069. G6P_DEHYDROGENASE. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1S4A8N1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGQLQLNPC SSSSVATTFH NGAHKFCRNF NILPFKAHSL ESSVASTFHN
60 70 80 90 100
GIYSRIQPRK HFEIMSSNGF HLNAVSLLDG SASKSMPEQV PLTELENAET
110 120 130 140 150
TVSITVIGAS GDLAKKKIFP ALFALFYEDC LPENFIVFGY SRTKMSDEEL
160 170 180 190 200
RNMISKTLTC RIDQRENCEA KMDHFLERCF YHSGQYNSED DFAELDYKLK
210 220 230 240 250
AKEGSRVSNR LFYLSIPPNI FVDVVRCASL KASSTSGWTR VIVEKPFGRD
260 270 280 290 300
LESSSELTRC LKKYLTEEQI FRIDHYLGKE LVENLSVLRF SNLVFEPLWS
310 320 330 340 350
RNYIRNVQFI FSEDFGTEGR GGYFDNYGII RDIMQNHLLQ ILALFAMETP
360 370 380 390 400
VSMDAEDIRN EKVKVLRSMR PLQLEDVVLG QYKGHSKGGK LYPAYTDDPT
410 420 430 440 450
VPNGSVTPTF SAAALFINNA RWDGVPFLMK AGKALHTRRA EIRVQFRHVP
460 470 480 490 500
GNLYKKNFGT DLDKATNELV LRLQPDEAIY LKINNKVPGL GMRLDRSDLN
510 520 530 540 550
LLYKAKYRGE IPDAYERLLL DAIEGERRLF IRSDELDAAW ALFTPLLKEL
560 570 580
EEKKIAPELY PYGSRGPVGA HYLAAKHNVR WGDLSGDD
Length:588
Mass (Da):66,806
Last modified:April 12, 2017 - v1
Checksum:i533F71DA15327E58
GO

Sequence databases

RefSeqiXP_016472939.1. XM_016617453.1.

Similar proteinsi

Entry informationi

Entry nameiA0A1S4A8N1_TOBAC
AccessioniPrimary (citable) accession number: A0A1S4A8N1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: October 25, 2017
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported