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Protein
Submitted name:

centromere-associated protein E

Gene

CENPE

Organism
Erinaceus europaeus (Western European hedgehog)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi86 – 93ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor proteinPROSITE-ProRule annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
centromere-associated protein EImported
Gene namesi
Name:CENPEImported
OrganismiErinaceus europaeus (Western European hedgehog)Imported
Taxonomic identifieri9365 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraErinaceidaeErinaceinaeErinaceus
Proteomesi
  • UP000079721 Componenti: Genome assembly

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 329Kinesin motorInterPro annotationAdd BLAST324

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili338 – 365Sequence analysisAdd BLAST28
Coiled coili493 – 534Sequence analysisAdd BLAST42
Coiled coili556 – 604Sequence analysisAdd BLAST49
Coiled coili638 – 686Sequence analysisAdd BLAST49
Coiled coili712 – 746Sequence analysisAdd BLAST35
Coiled coili753 – 801Sequence analysisAdd BLAST49
Coiled coili830 – 951Sequence analysisAdd BLAST122
Coiled coili956 – 976Sequence analysisAdd BLAST21
Coiled coili1043 – 1095Sequence analysisAdd BLAST53
Coiled coili1114 – 1200Sequence analysisAdd BLAST87
Coiled coili1389 – 1458Sequence analysisAdd BLAST70
Coiled coili1465 – 1495Sequence analysisAdd BLAST31
Coiled coili1503 – 1537Sequence analysisAdd BLAST35
Coiled coili1549 – 1635Sequence analysisAdd BLAST87
Coiled coili1668 – 1726Sequence analysisAdd BLAST59
Coiled coili1755 – 1782Sequence analysisAdd BLAST28
Coiled coili1797 – 1817Sequence analysisAdd BLAST21
Coiled coili1846 – 1866Sequence analysisAdd BLAST21
Coiled coili1874 – 1901Sequence analysisAdd BLAST28
Coiled coili2165 – 2192Sequence analysisAdd BLAST28
Coiled coili2252 – 2286Sequence analysisAdd BLAST35
Coiled coili2316 – 2336Sequence analysisAdd BLAST21
Coiled coili2381 – 2411Sequence analysisAdd BLAST31

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiView protein in InterPro
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR036961. Kinesin_motor_dom_sf.
IPR027417. P-loop_NTPase.
PANTHERiPTHR24115. PTHR24115. 3 hits.
PfamiView protein in Pfam
PF00225. Kinesin. 1 hit.
PRINTSiPR00380. KINESINHEAVY.
SMARTiView protein in SMART
SM00129. KISc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1S3WUG6-1 [UniParc]FASTAAdd to basket

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        10         20         30         40         50
MAEEGAVAVC VRVRPLNSRE EALGEDTQVY WKTDNNVIYQ ADGSKSFNFD
60 70 80 90 100
RVFNSSETTK HVYEEIAVPI IDSAIQGYNG TIFAYGQTAS GKTYTMMGSK
110 120 130 140 150
DYLGVIPRAI HDIFQKIKKF PDREFLLRVS YMEIYNDTIT DLLCDTLKMK
160 170 180 190 200
PLIIREDFNR NVYVSDLTEE VVYTSEMALK CITKGEKNRH YGATKMNQRS
210 220 230 240 250
SRSHTIFRMI LESREKGEPS NCDGSVKVSH LNLVDLAGSE RAAQTGAEGV
260 270 280 290 300
RLKEGCNINR SLFILGQVIK KLSDGQAGGF INYRDSKLTR ILQNSLGGNA
310 320 330 340 350
KTRIICTITP VSYDESLTTL QFASTAKHMK NTPYVNEVSS DEALLKRYRK
360 370 380 390 400
EIMDLKKQLE EVSLETRAQA MEKDQLAQLL EEKDLLQKVQ NEKIQNLTQM
410 420 430 440 450
LVTSSSLTSQ QELKAKKKRR VTWCVGKINK MKDSNYMSEF SMPANVATRT
460 470 480 490 500
HRATLSSVGE IDESLCSEAD VFSSTLDSLA DVEWNPATKL LSQETLESEL
510 520 530 540 550
SSLRANYDNL VLDYEELRRE REEMESKLKE KKDLDEFEAL EKRVEKDQEM
560 570 580 590 600
QLIHEISNLK NLVKHAEVYN QDLENELSSK IELLKEKEEQ IEKLMASQKS
610 620 630 640 650
ESRKAELSES SELTENLTHM KQSLFDAEAI ALDSKRESAF LRSENLELKE
660 670 680 690 700
KMKELSSACS QMEKDIQAYH RQLEAKKKMQ VDLERELQSS YSEITKLSSL
710 720 730 740 750
VDGRVPNDLL SNLELERKIT ALQKELHKEA NENEALRNEI HVLSELKPLP
760 770 780 790 800
SEVERLQKEI HDKSEELKVV TSEKEKLSCD VAERERRIQG LLEERERTQG
810 820 830 840 850
DQAAPQPGPT GADQEAQDVG TQHTEAEQKH RAALDENTRM RQAVESLSRE
860 870 880 890 900
LQSRSLSLAT AERELSRKTQ ELEQRTAESQ QKLSELEQLK EQLGSGASRL
910 920 930 940 950
QAVEREKNEV AGRLQEALGE VRALTQEKDT LQQLQESLQT ERDQLRSDIQ
960 970 980 990 1000
DMVVMNIDTQ EQLRNALESL KQQQQTTNTL SVKTATEASS GSLHVAGSTG
1010 1020 1030 1040 1050
GAESERQEQV GRLATRQSLE GRAAPVLAVG VEGSGPADEQ RKVLSLVQEK
1060 1070 1080 1090 1100
AELQCRLERV TAEKEQLQAD LQESIEMTIE NQEELRILRE ELKKQRGMSH
1110 1120 1130 1140 1150
SSQEEELSRG SEKLAEIRGE LQEKSQRLQE SQQRLLRAQA EVSEVRQELE
1160 1170 1180 1190 1200
EMENVKGQLQ NQMQKLEQAE RERLELAQKL REAHEKLEAV TREREELRGH
1210 1220 1230 1240 1250
TRAVGVTWEG RRVSSESASG QGDCSRPGAG RTPGPGAQSS VDSDPAQGLQ
1260 1270 1280 1290 1300
AESSKRVAEA EAARASGGRG TLCWRCSGGK EGGSAPALLP DSTVHSNEGQ
1310 1320 1330 1340 1350
VPPARDAQQQ SLSTRGEGSE RETLGSVEQS QEPLGAEEVA LPGPEGEQPA
1360 1370 1380 1390 1400
SPVRRQAGQD ERKPPAEETG HRRLPKELLS ERDQPREAMR ELEAKHRETQ
1410 1420 1430 1440 1450
QELEVTLCRV KEREDAISEL RTALSERERE VSSLQRELGT ASAELQRKTQ
1460 1470 1480 1490 1500
ELHEKQEQLI GLRGAGEAQE RVSELKQLRE RLTAAESSLH SSQAESLRLA
1510 1520 1530 1540 1550
QRIQEGQQEV ATAMRERDEL RREREGLRGS LKEAVAEIQE HRLLQTKAAG
1560 1570 1580 1590 1600
EAQDRVNELE SMKRQLEAQK SALKSTDTEK AELTQKLQDG LEEMRRVLKE
1610 1620 1630 1640 1650
ADELRSTEKA LRAEKEQLEQ SLKAAALREL EKQEELAGSL KLLKGHQAAQ
1660 1670 1680 1690 1700
EELRADVSEK THLVSSLQTD LEHTISVLEA QTQELQEREH RLREVESHLK
1710 1720 1730 1740 1750
ENVREAAQLR EQLKAKSSAL ESTAAEKLRL TQNLQESLGA IACLTEERDG
1760 1770 1780 1790 1800
LRRTEETAVA ERDQLRAQLQ RAEAMVQELQ ASQHQDASER QKNTTEIEQL
1810 1820 1830 1840 1850
REQVKDQSVT LNRIEMENLN FAQKLHHNIE ELKSVTKERD NLKTVEEALS
1860 1870 1880 1890 1900
LERDQLRDSL RETTARDLET QQQLKMAHQR LKEHQETIDR LRERVSEKTS
1910 1920 1930 1940 1950
QMPHVQKGLN KSTEELREKA QQDHGEAVTC GEGLPCDGAN PTVSLREKCL
1960 1970 1980 1990 2000
RIKELLKQYP ELYPQHACLG GLSLDVEEEV QVQKELSARI KEKLALHCAQ
2010 2020 2030 2040 2050
AGSVHKLLAK NLSCSMEFLR VLEKVQYVLD NVTTIKEEHH GALCKLEAGC
2060 2070 2080 2090 2100
VGEVERQAEL LDGGHGGAPG TQARALTLGQ KLDQHIEEIV RDFSGSDFPS
2110 2120 2130 2140 2150
IKAELEAAVS NSKDMTRFLR ECLATHADTE KLTGGLQQAI DRMYRVNYLY
2160 2170 2180 2190 2200
GSRMIAMMNE STAFEESHSA LAKQWEQELK SLKEENRELL KTRQPPGALP
2210 2220 2230 2240 2250
YTAAARDAGQ PRAAVGATQQ AAEAVPGPGA QLHGAGESAA QKERPGQAQK
2260 2270 2280 2290 2300
ELEAARGVIS KLQRRVEELD QHLLKAKEMN QALQDRVSLG AQPYREQLED
2310 2320 2330 2340 2350
LKMQLVKTDL DKKQRAKEFE KEMASVKAAV DHQKEVIRVL KEELRRSQSS
2360 2370 2380 2390 2400
QDTSSELTLS EPPHKPWTCG GGSGVVQSTK ALILKSEYAR LEKENSRLRR
2410 2420 2430 2440 2450
QNERLLRQQD ALAGGTQHPA PEVTSPQERT LRRVVRRERP SCENTPPESP
2460 2470 2480 2490 2500
GVPAATKKRP HVSSPCQERA APAPGPLGSP RAKSLPAPPT RFFDNSGLGL
2510 2520 2530
CPEPQVLEDE SEPPAPDAQL ANARAAPECR VQ
Length:2,532
Mass (Da):284,829
Last modified:April 12, 2017 - v1
Checksum:i583BBE15D50C62FD
GO

Sequence databases

RefSeqiXP_016049975.1. XM_016194489.1.

Genome annotation databases

GeneIDi103126572.

Entry informationi

Entry nameiA0A1S3WUG6_ERIEU
AccessioniPrimary (citable) accession number: A0A1S3WUG6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: December 20, 2017
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported