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Protein
Submitted name:

leucine-rich repeat serine/threonine-protein kinase 2

Gene

LRRK2

Organism
Erinaceus europaeus (Western European hedgehog)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionKinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
leucine-rich repeat serine/threonine-protein kinase 2Imported
Gene namesi
Name:LRRK2Imported
OrganismiErinaceus europaeus (Western European hedgehog)Imported
Taxonomic identifieri9365 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraErinaceidaeErinaceinaeErinaceus
Proteomesi
  • UP000079721 Componenti: Genome assembly

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1278 – 1461RocInterPro annotationAdd BLAST184
Domaini1829 – 2086Protein kinaseInterPro annotationAdd BLAST258

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili274 – 297Sequence analysisAdd BLAST24

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
1.25.40.20. 1 hit.
2.130.10.10. 1 hit.
3.80.10.10. 4 hits.
InterProiView protein in InterPro
IPR036770. Ankyrin_rpt-contain_sf.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR032171. COR.
IPR011009. Kinase-like_dom_sf.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR032675. LRR_dom_sf.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR020859. ROC_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR005225. Small_GTP-bd_dom.
IPR015943. WD40/YVTN_repeat-like_dom_sf.
IPR036322. WD40_repeat_dom_sf.
PfamiView protein in Pfam
PF16095. COR. 1 hit.
PF13855. LRR_8. 2 hits.
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00369. LRR_TYP. 7 hits.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF48371. SSF48371. 3 hits.
SSF50978. SSF50978. 1 hit.
SSF52058. SSF52058. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51450. LRR. 11 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS51424. ROC. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1S3WM38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDPKICMSE ALDIPVLVPS TPLGWSLLCK LIEICPNTLQ SLMGPRDVGR
60 70 80 90 100
DWEVLGVHQL ILKMLTAHSS SVSLSTVGLR ALDLLLTSGK ITLLILDEDS
110 120 130 140 150
DIFLLIFDAM RTFSASDEVQ KLGCKALRVL FERVSEEQLT EFVENKDHVI
160 170 180 190 200
LLDALNHFKE DEEIVLHVLH CLNSLAVPCS NVEVLMSGNV RCYNLVVDAM
210 220 230 240 250
KMFPDEERIQ EVSCCLLHRL TLGNFFNILV LNEVHEFVVQ ALQRFPQNAA
260 270 280 290 300
LQLAALSCLA LLTETIFLNH DLEEKSESGE NEQYKEEEEE EEEEEELFWL
310 320 330 340 350
EACYRALTRH RKDKHVQEAA CWALNNLLMY QNSLHKKIGD EDGQFPAHRE
360 370 380 390 400
VMLSMLMHSS SKGVFQASAD ALSTLLEQND NFRKILLSKG IFLNVLELMQ
410 420 430 440 450
RHIQSPQVAE SGCKMLNHLF EGSHTCLDTV AAVAPRILTI MRSHATMPGV
460 470 480 490 500
QLAALRTLVH FLAPAIPEES KEDTEEQQHK LIVFQKECMQ NEMPKLVLAS
510 520 530 540 550
LNRFIGNPGI QKCGLSVLSW MARVPEAPEV LALEGALDSV LHTLEMFPDD
560 570 580 590 600
HGIQCLGLSL VGHLVTRKTL CIGTGHLLAK ILISSLQRFT DATDLQTEGF
610 620 630 640 650
QTVLKIQELW APFSKLLLHH SFESILFHQM TSSAVEPQDW QLLHLCCKCF
660 670 680 690 700
AKVALDEELK GILLQRACEQ NDSTMAECLL LLGADANRAT EPEPLICQVC
710 720 730 740 750
EKASSPRLVE LLLDGGCREQ DVRTALTISL GRGDGRVISL LLRRLALDLA
760 770 780 790 800
NSSVCLGGLC LGSLQPSWLI PLFPHRTPSV RRETNLGSTL ARMVLRYQRL
810 820 830 840 850
SVAENRAASG CDHNAAEEDG LDKLDDWTFL PECFVDNVFG QNDDLDSEGS
860 870 880 890 900
EGSFLVKKKS NSINVGEFYR GPALQHCSPT LQRQTSSLGP TFDQEDSRKQ
910 920 930 940 950
KRKKLLSDDS FWSLKAHTRP SDSTSLLTCE REHITSLDLS ANELRDVDAL
960 970 980 990 1000
GQPGVLSRPL EHLQRLELQQ NLLSSFPPLL CDTLRSLTYL DLHSNKFTSF
1010 1020 1030 1040 1050
PSHLLKMNRI ASLDVSRNDI GPLVALNPAV KCATLRQLNL SYNQLSALPE
1060 1070 1080 1090 1100
NLGSVVGRLE QLLLEGNKIS GICLPLDLKE LKMLNLSKNH ISSLPEDFLE
1110 1120 1130 1140 1150
ACPKVESFSA RMNFLSAMPF LPSSVTNLKL SQNRFTSVPE AILNLPHLRS
1160 1170 1180 1190 1200
LDLSSNELQS VPSPAHWRSL SLRELLFSHN QISSLDLSEK AHTWARMEKL
1210 1220 1230 1240 1250
HLAYNRLKEI PPEIGCLENL TSLDVSHNSE LRSFPNEMGK LNKIWDLPLD
1260 1270 1280 1290 1300
ELRLNCDFKH VGCKAKDIIR FLQQRLKKAV PYNRMKLMVV GNTGSGKTTL
1310 1320 1330 1340 1350
LHQLMKTKKS EPGAPGTTVG IDVKDWPIHI RGRGKRDLTL NVWDFAGQEE
1360 1370 1380 1390 1400
FYSTHPHFMT PRALYLAVYD LSKGPSEVDA MKPWLFNIKA RASSSPVILV
1410 1420 1430 1440 1450
GTHLDVSDER QRRTCISKIT KELLNKRGFP AIRDYHFVNA TEESDALAKL
1460 1470 1480 1490 1500
RKTIINESLN FKIQDQPVVG QLVPDCYVAL EKVILSERKN VPPEFPVIGR
1510 1520 1530 1540 1550
KHLLQLVEEK QLELDENELP HAVHFLNESG VLLHFQDPAL QLSDLYFVEP
1560 1570 1580 1590 1600
KWLCKVMAQI LTVKVEGCSK HPKGIISRRD VENFLSKKKR FPKNYMSQYF
1610 1620 1630 1640 1650
KLLEKFQIAL PIGEEYLLVP SSLSDHRPVI ELPHCENSEV IVRLYEMPYF
1660 1670 1680 1690 1700
PMGFWSRLIS RLLEISPYML SGRERALRPN RMYWRQGIYL NWSPEAYCLV
1710 1720 1730 1740 1750
GSEVLDRHAE SFLKITVPSC RKGCILLGQV VDHIDSLMEE WFPGLLEIDV
1760 1770 1780 1790 1800
CGEGETLLKK WALYSFNDGE EHQRILLDDL MRKAEQGDLL VSPDHPRLTV
1810 1820 1830 1840 1850
PIAQIAPDLI LADLPRNIML NNDELEFEQA PEFLLGDGSF GSVYRASYEG
1860 1870 1880 1890 1900
EEVAVKIFNK HTSLRLLRQE LVVLCRLHHP SLVSLLAAGV RPRMLVMELA
1910 1920 1930 1940 1950
GRGSLDRLLQ QEGGLPRTLQ HRIALHVADG LRYLHSAMII YRDLKPHNVL
1960 1970 1980 1990 2000
LFTLYPNAAV IAKIADYGIA QYCCRMGIKT SEGTPGFRAP EVARGNVIYN
2010 2020 2030 2040 2050
QQADVYSFGL LLYDILTNGS RIAEGLKFPN EFDELAIQGK LPDPVKEYGC
2060 2070 2080 2090 2100
APWPMIEKLI KKCLQENPQE RPTSAQVFDI LNSPALVCLM RLVSLPDNLL
2110 2120 2130 2140 2150
VECMAASSQN GKPGCVWLGC GLPDKGQVLV LDLNAEELNS EEVADSRILS
2160 2170 2180 2190 2200
LALVQFPAEK AVWAVCGTQS GTLLAINTKD RREKHNLQRM GDSVTCLYST
2210 2220 2230 2240 2250
SSRQSKQKNF LLVGTAHGEL VIFEDTAVKY KGAAPLKTLN LGDVSTPLMC
2260 2270 2280 2290 2300
LSESMVSAEK SITWGACGTK IFSLSSDFTI QKLIETRTSQ LFSYRTFSDS
2310 2320 2330 2340 2350
SIIAVVVDSV LYVAKKNSPF VEVWDKKTEK LCQLIDCALF LKEEMSRVSP
2360 2370 2380 2390 2400
GSQPRMPYCG RVKTLCLQKN TALWVGTGGG HILLLDLSTR RVLRVIHNIC
2410 2420 2430 2440 2450
DSVRAMMTAQ SGSLKNVMLV LGYSQKNSED TGHPRELQSC LSVWDINLPH
2460 2470
EVQNLDKHIE MRQELAETMR RIPLE
Length:2,475
Mass (Da):278,116
Last modified:April 12, 2017 - v1
Checksum:i419C62E208A7E479
GO

Sequence databases

RefSeqiXP_016047443.1. XM_016191957.1.

Genome annotation databases

GeneIDi103121251.

Similar proteinsi

Entry informationi

Entry nameiA0A1S3WM38_ERIEU
AccessioniPrimary (citable) accession number: A0A1S3WM38
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: November 22, 2017
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported