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Protein
Submitted name:

tyrosine-protein kinase receptor Tie-1 isoform X1

Gene

TIE1

Organism
Erinaceus europaeus (Western European hedgehog)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionKinase, ReceptorSAAS annotationImported, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
tyrosine-protein kinase receptor Tie-1 isoform X1Imported
Gene namesi
Name:TIE1Imported
OrganismiErinaceus europaeus (Western European hedgehog)Imported
Taxonomic identifieri9365 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraErinaceidaeErinaceinaeErinaceus
Proteomesi
  • UP000079721 Componenti: Genome assembly

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei768 – 793HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501037039223 – 1145Sequence analysisAdd BLAST1123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi244 ↔ 253PROSITE-ProRule annotation
Disulfide bondi333 ↔ 342PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini223 – 254EGF-likeInterPro annotationAdd BLAST32
Domaini314 – 343EGF-likeInterPro annotationAdd BLAST30
Domaini349 – 440Ig-likeInterPro annotationAdd BLAST92
Domaini444 – 541Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini543 – 640Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini653 – 746Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini846 – 1125Protein kinaseInterPro annotationAdd BLAST280

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, Immunoglobulin domainSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

CDDicd00063. FN3. 3 hits.
Gene3Di2.60.40.10. 5 hits.
InterProiView protein in InterPro
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR003961. FN3_dom.
IPR036116. FN3_sf.
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
PfamiView protein in Pfam
PF00041. fn3. 3 hits.
PF00047. ig. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiView protein in SMART
SM00181. EGF. 3 hits.
SM00060. FN3. 3 hits.
SM00409. IG. 2 hits.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF49265. SSF49265. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1S3WFZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLKSTWLF PILFLASHVG AAVDLTLLAD LRLTDPQRFF LTCVSGETGR
60 70 80 90 100
GSDAWGEPLL LEKDDRIVRT PRSWPPRLAR NGSHQLTLQG FSQPSDLVGV
110 120 130 140 150
FSCVGGAGAR RTRVVYVHNS PGAHLHPDRV THTVNKGDTV VLSARVHKEK
160 170 180 190 200
QTDVIWKSNG SYFYTLDWHE AQDGQFLLQL PNVQPSLSGI YSATYLEASP
210 220 230 240 250
LGSAFFRLIV RGCGAGRWGP GCTKECPGCL HGGVCHDQDG ECVCPPGFTG
260 270 280 290 300
TRCEQACREG RFGQRCQEQC PGTSGCQGLT FCLPDPYGCS CGSGWRGSQC
310 320 330 340 350
QEACASGHFG ADCRLRCQCQ NGGTCDRFSG CVCPSGWHGV HCEKSDRIPQ
360 370 380 390 400
ILDVASELEF NLGTMPRIHC AAAGNPFPVR GSMELRKPDG TVLLSSKAIV
410 420 430 440 450
EPDRTTAEFE VSHLALGDSG LWECRVSTSG GQDSRRFRVN IRVPPVPLAA
460 470 480 490 500
PLLLARQSRQ LVISPLVSFS GDGPITSVRL HYRPQDSTVD WSAIVVDPSE
510 520 530 540 550
NVTIVNLRPK TGYSIRVQLS RPGEGGQGAP GPPAFMTTDC PEPLLQPWLE
560 570 580 590 600
SWHLEGPDRL RVSWSLPLVA GPLVGDGFLL RLWDGARGQE RRENVSSPQA
610 620 630 640 650
RTALLTGLTP GTKYQLDVRL YHCTLLGPAS PTARVQLPPS GPPGPPGPPG
660 670 680 690 700
PPAPRHLHAQ ALSESEIQLT WQRPEAAAEP ISKYIVEMQV AGGSGDPQWM
710 720 730 740 750
DVDRPEETST IVRGLNASTR YLFRVRASIQ GPGDWSNMVE ESTLGNGLQS
760 770 780 790 800
EGPIQEIRAA EEGLDHQLIL AVVGSVSATC LTILAALLTL VCIRRSCLHR
810 820 830 840 850
RRTFTYQSGS GEETILQFSS GTLTLTRRPK PQPEPLNYPV LEWEDITFED
860 870 880 890 900
LIGEGNFGQV IRAMIKKDGL KMNAAIKMLK EYASENDHRD FAGELEVLCK
910 920 930 940 950
LGHHPNIINL LGACENRGYL YIAIEYAPYG NLLDFLRKSR VLETDPAFAR
960 970 980 990 1000
EHGTASTLSS RQLLRFASDA ANGMQYLSEK QFIHRDLAAR NVLVGENLAS
1010 1020 1030 1040 1050
KIADFGLSRG EEVYVKKTMG RLPVRWMAIE SLNYSVYTTK SDVWSFGVLL
1060 1070 1080 1090 1100
WEIVSLGGTP YCGMTCAELY EKLPQGYRME QPRNCDDEVY ELMRQCWRDR
1110 1120 1130 1140
PYERPPFAQI ALQLGRMLEA RKAYVNMSLF ENFTYAGIDA TAEEA
Length:1,145
Mass (Da):125,922
Last modified:April 12, 2017 - v1
Checksum:i57743F018BFAC73B
GO

Sequence databases

RefSeqiXP_016045054.1. XM_016189568.1.

Genome annotation databases

GeneIDi103116227.

Similar proteinsi

Entry informationi

Entry nameiA0A1S3WFZ8_ERIEU
AccessioniPrimary (citable) accession number: A0A1S3WFZ8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: October 25, 2017
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported