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Protein

NADPH:adrenodoxin oxidoreductase, mitochondrial

Gene

FDXR

Organism
Erinaceus europaeus (Western European hedgehog)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2 reduced adrenodoxin + NADP+ = 2 oxidized adrenodoxin + NADPH.UniRule annotation

Cofactori

FADUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei51FAD; via amide nitrogenUniRule annotation1
Binding sitei72FADUniRule annotation1
Binding sitei80FAD; via amide nitrogenUniRule annotation1
Binding sitei116FAD; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei243NADPUniRule annotation1
Binding sitei401FAD; via amide nitrogenUniRule annotation1
Binding sitei408NADP; via amide nitrogenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi187 – 190NADPUniRule annotation4
Nucleotide bindingi231 – 232NADPUniRule annotation2
Nucleotide bindingi408 – 410FADUniRule annotation3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandFADUniRule annotation, Flavoprotein, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH:adrenodoxin oxidoreductase, mitochondrialUniRule annotation (EC:1.18.1.6UniRule annotation)
Gene namesi
Name:FDXRImported
OrganismiErinaceus europaeus (Western European hedgehog)Imported
Taxonomic identifieri9365 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraErinaceidaeErinaceinaeErinaceus
Proteomesi
  • UP000079721 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MitochondrionUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_501036353325 – 494NADPH:adrenodoxin oxidoreductase, mitochondrialSequence analysisAdd BLAST470

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 198FAD/NAD-binding_domInterPro annotationAdd BLAST157

Sequence similaritiesi

Belongs to the ferredoxin--NADP reductase type 1 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiView protein in InterPro
IPR036188. FAD/NAD-bd_sf.
IPR023753. FAD/NAD-binding_dom.
IPR021163. Ferredox_Rdtase_adrenod.
PfamiView protein in Pfam
PF07992. Pyr_redox_2. 1 hit.
PIRSFiPIRSF000362. FNR. 1 hit.
SUPFAMiSSF51905. SSF51905. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1S3WDT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRCWRWWH WSAWPWTQPP PARSFATPGF SQQFSTQEQI PQFCVVGSGP
60 70 80 90 100
AGFYTAQHLL KHHPRARVDI YEKQLVPFGL VRFGVAPDHP EVKNVINTFT
110 120 130 140 150
QTARSDRCAF LGHVVVGRDV TVRELQEAYH AVVLSYGAED HQALGIPGEE
160 170 180 190 200
LPGVLSARAF VGWYNGLPEN RELAPDLSHD TAVILGQGNV ALDVARIILT
210 220 230 240 250
PPEHLEKTDI TEAALGVLRQ SRVKMVWIVG RRGPLQVAFT IKELREMIQL
260 270 280 290 300
PGTRPILDPA DFLGLQDRIK DALRPRKRLT ELLLQTAMEK PGPEVAARWV
310 320 330 340 350
QASRAWGLRF FRIPQQVLSS PDGQRVAGIR LAVTRLEGAG ETARAVPTGD
360 370 380 390 400
VEDLPCGLVL SSVGYKSRPI DPSVPFDPKL GVIPNVEGRV VDVPGLYCSG
410 420 430 440 450
WVKRGPTGVI TTTMADSFLT GQTLLQDLKS GLLPSGPRPG SAAIVALLSS
460 470 480 490
RGIRPISFSD WEKLDAEEVS RGQALGKLRE KILDPQEMLQ FLGR
Length:494
Mass (Da):54,415
Last modified:April 12, 2017 - v1
Checksum:i61870E4F30B60D5A
GO

Sequence databases

RefSeqiXP_016044548.1. XM_016189062.1.

Genome annotation databases

GeneIDi103114930.

Similar proteinsi

Entry informationi

Entry nameiA0A1S3WDT9_ERIEU
AccessioniPrimary (citable) accession number: A0A1S3WDT9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: March 28, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported