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Protein

Tyrosine-protein phosphatase non-receptor type

Gene

ptn6

Organism
Salmo salar (Atlantic salmon)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei492SubstrateUniRule annotation1
Active sitei526Phosphocysteine intermediateUniRule annotation1
Binding sitei573SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphataseUniRule annotationSAAS annotation, ReceptorImported

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor typeUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
Name:ptn6Imported
OrganismiSalmo salar (Atlantic salmon)Imported
Taxonomic identifieri8030 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo
Proteomesi
  • UP000087266 Componenti: Genome assembly

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 170SH2InterPro annotationAdd BLAST97
Domaini180 – 283SH2InterPro annotationAdd BLAST104
Domaini318 – 588Tyrosine-protein phosphataseInterPro annotationAdd BLAST271
Domaini503 – 579TYR_PHOSPHATASE_2InterPro annotationAdd BLAST77

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.UniRule annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Family and domain databases

Gene3Di3.30.505.10. 2 hits.
3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR000980. SH2.
IPR036860. SH2_dom_sf.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR012152. Tyr_Pase_non-rcpt_typ-6/11.
IPR000387. TYR_PHOSPHATASE_dom.
PfamiView protein in Pfam
PF00017. SH2. 2 hits.
PF00102. Y_phosphatase. 1 hit.
PIRSFiPIRSF000929. Tyr-Ptase_nr_6. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
PR00401. SH2DOMAIN.
SMARTiView protein in SMART
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
SM00252. SH2. 2 hits.
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEiView protein in PROSITE
PS50001. SH2. 2 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1S3MX42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMKRFYCGD IYKVSLFVRD SGLSACLVPV CLLLSLFCEK SHKKEGRSER
60 70 80 90 100
VSQNDREKKK VGTEEEVKVK MVRWFHRDIS GLDAESVLKS RGIHGSFLAR
110 120 130 140 150
PSRKNQGDFS LSVRVGELVT HIRIQNTGDF YDLYGGEKFA TLSELVEYYT
160 170 180 190 200
AENGILQDKD GTIIELKYPF NCSDPTTERW YHGHLSGPNA EKLLWERDEP
210 220 230 240 250
GTFLVRESLS KPGDFVLSVL TEEKSKASSG GRRVSHIKIM CQNDRYTVGG
260 270 280 290 300
TEMFDTLADL MEHYKRKGIE EMSGTWVHLK QPYFSTRVNA ADIDSRVRLL
310 320 330 340 350
DQTAERENEG DKKSKAGFWE EFDALQKQET KVKKSREEGM RPENKSKNRY
360 370 380 390 400
KNILPFDETR VILSSGDPNI IGSDYINANY VTNKLQESGD QKVYIACQGC
410 420 430 440 450
LATTVNDFWQ MVWQEKTRVI VMTTREVEKG RNKCVPYWPE MQGSKEVGPY
460 470 480 490 500
VVTCVSERDA TDYKVRVMEI SPLDQSDSVR TIWHYQYLSW PDHGVPEEPG
510 520 530 540 550
GVLSFLSQVN LKQAEFTNAG PMIIHCSAGI GRTGTIVVID MIIKTIDTKG
560 570 580 590 600
LDCDIDIQKS IQMVRDQRSG MVQTEAQYKF IYLAVSEYIE ASKTYNKGAE
610 620 630 640 650
TEYGNLQFKH QPASRKVSKN KEQELYENLA KGKKDVKKQK SEEKKSGSVR

KR
Length:652
Mass (Da):74,495
Last modified:April 12, 2017 - v1
Checksum:iCFEA0391BEA94DE9
GO

Sequence databases

RefSeqiXP_014007769.1. XM_014152294.1.
UniGeneiSsa.5973.

Genome annotation databases

GeneIDi100195421.

Similar proteinsi

Entry informationi

Entry nameiA0A1S3MX42_SALSA
AccessioniPrimary (citable) accession number: A0A1S3MX42
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: October 25, 2017
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported