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Protein
Submitted name:

leucine-rich repeat serine/threonine-protein kinase 2 isoform X1

Gene

lrrk2

Organism
Salmo salar (Atlantic salmon)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionKinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
leucine-rich repeat serine/threonine-protein kinase 2 isoform X1Imported
Gene namesi
Name:lrrk2Imported
OrganismiSalmo salar (Atlantic salmon)Imported
Taxonomic identifieri8030 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo
Proteomesi
  • UP000087266 Componenti: Genome assembly

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini722 – 780ANK_REP_REGIONInterPro annotationAdd BLAST59
Domaini1349 – 1530RocInterPro annotationAdd BLAST182
Domaini1898 – 2161Protein kinaseInterPro annotationAdd BLAST264

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 24Sequence analysisAdd BLAST24

Keywords - Domaini

Coiled coilSequence analysis, Leucine-rich repeatSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

KOiK08844

Family and domain databases

Gene3Di1.25.10.10, 2 hits
2.130.10.10, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR032171 COR
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR025875 Leu-rich_rpt_4
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR027417 P-loop_NTPase
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR020859 ROC_dom
IPR008271 Ser/Thr_kinase_AS
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF16095 COR, 1 hit
PF12799 LRR_4, 1 hit
PF13855 LRR_8, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 8 hits
SM00220 S_TKc, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits
SSF48403 SSF48403, 1 hit
SSF50978 SSF50978, 2 hits
SSF52540 SSF52540, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS51450 LRR, 13 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS51424 ROC, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1S3KRD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNKEELEER LKKLLVRLKN LQEGKQLSTL VQIIQDLLFL AHTDDCAAEL
60 70 80 90 100
FEDKDVHGPL MVVLSTYSNS RGVQQVGWSL LCRLMEICPS TLDSLVSPLG
110 120 130 140 150
AGKDWEVLGV HQQILKVLSQ HSGDCRVMMV GLRALALLLR SDVIVLLIRD
160 170 180 190 200
EEEDVFSLIV EGMKTFPSSE EVQIQGCRGL QLLLDRVSDD DLVEFLENQD
210 220 230 240 250
HSVVLGALQR FHDSEDLFLQ AMKVLLPLAG PASNVEILMS GGERCYSVVA
260 270 280 290 300
GAMESFPEVE ALQEVGCCLF RKFTSERYCS ILVLNGVHRV TVRACLTYPE
310 320 330 340 350
NATLQAAALS CLAALTQTIV QSKAVVNEGM EEGEAEENRG KEEVVDDVGL
360 370 380 390 400
CWMQACCRAL EVHAADSTVQ EAACWAIHSL LLYGSESWHH STEEQDGRTP
410 420 430 440 450
VHRQIMAAML LHSSSPGVFQ AAASAMGTLI TYNSKMQSLL LSNGLHVNVV
460 470 480 490 500
EMMKRHLSSP EVSAGGCKLL HLLFKGRTAS LDELNMAMGQ ILRAMKAHNF
510 520 530 540 550
IPEVQLEALR ASLAFLCPDR SLRVSDHGVS VADPDTVDVS LRVQKNQSVV
560 570 580 590 600
EGAHTVYLET LNRFISSAAI QECGLRVLSA LADCSGAVDL LCQQGAIDTV
610 620 630 640 650
LHTLQMFPRE REIHYWGLNL LYCLVSKKKL SRMIVPVLAS VLVTSLLQYR
660 670 680 690 700
EDTEMLLKGF QVALRMLDAC SGAAGELQRE GFDRQIFLQL KEEPPDRCSY
710 720 730 740 750
PLSQLRKAAC LALSKMCGDA ELRYSMLEKA CKDGDVLMAE CLIQLGADIN
760 770 780 790 800
KKTKTESLIY QVCEQGGPLE LVVLLLSRGV HEQHLRGALG ASVRRGDGPA
810 820 830 840 850
VIQLLGRLGL DLNNNALCLG GFRLGRVDAA WLIPLLSERG RANSLRSSTS
860 870 880 890 900
KGACLARYVL SFQRGKTIPT PSTPSSRADP CLTSGYMSDE SDDSSFLSLE
910 920 930 940 950
DSLVFNDDME SDGSDSLSLA LSPMSTNDLS EEWKAGSQKR KNGRRRHFSS
960 970 980 990 1000
ESCIHPQGVQ GEVELNEPLQ RRYGRTTPNQ KGIHSPVLSS GYNSSPLGGD
1010 1020 1030 1040 1050
REWIRLLDLS GNELDSVSCL LDEGSIRQQL EHLYRLDLSQ NSLSEFPSGL
1060 1070 1080 1090 1100
CESLKSLTRL DLQGNQLQSL PAELLALPSL SMLNVSRNCV GPLLTLDPAV
1110 1120 1130 1140 1150
TCPSLRQLNL SYNHITTFPH QLGRAMERLE ELSLEGNRMS ELWSPLCLPE
1160 1170 1180 1190 1200
MKLLDISKNS VESISRDFLS GCPKLENFSA CTNQLSSLSH LPSKITTLKL
1210 1220 1230 1240 1250
SQNSFTTIPQ AVLDLPNLRS VDMRTNDITV LPGPCAWASV NLRELMFGQN
1260 1270 1280 1290 1300
RIGVLDLSGP EVYKWARLEK LHLSDNKLTE VPPQIGLLEE LTSLDLSRNG
1310 1320 1330 1340 1350
GLRSFPDEMG KLSRLWDLPL DGLRLSLDLK HIGNKTKDIV RFLQQRLKKA
1360 1370 1380 1390 1400
VPYYRMKLIV VGNADSGKTA LIRQLMKLKR SQWQMERPTV GIDVRDWTIR
1410 1420 1430 1440 1450
DRDKKNMVLN VWDFSGGEEF SGSHPHFLTP RALYLVVYDL SKGAAQVDAL
1460 1470 1480 1490 1500
KPWLFNIKAV APLSPVILVG THTDVSEDFQ LQACLDKIRQ ELLNHQGFPA
1510 1520 1530 1540 1550
IRDYHMVAVC EDSDAIGRLR KAIAREVASF KIQGQLVMGQ LVPESYLELE
1560 1570 1580 1590 1600
RRVLLERARV PGEFPVLRHQ YLLQLIQESQ IQLEEAELPH AVHFLSEAGV
1610 1620 1630 1640 1650
LLHFDDPALQ LRELYFIDPQ WLCNIISQKL SLKSSGFWEN PKGVVQRSMV
1660 1670 1680 1690 1700
ERFLFESKCF PKHHLTQYFK LLEKFQIALP FGEDQLLVPS SLSKHRPVIE
1710 1720 1730 1740 1750
MPHCENSEVI VRLYEMPYFP MGYWSRQINR LLEVSSYMLC GRERELRPNR
1760 1770 1780 1790 1800
IYWRRGIYLS WSPEAYCLVE AANVEDNPAS FVKITVPCSR KGRVLLGQVV
1810 1820 1830 1840 1850
DHVDSLLEEW FPGLLTTDIH GNGETLLKKW ALYSFKDGQE WSKILLEDLF
1860 1870 1880 1890 1900
THIDKDCLLV NPEDPRCTVP ISQIAPDLIL SDQPAGIILD SEELEMDLTK
1910 1920 1930 1940 1950
ENLLGDGGFG SVYRGIYKNE EVAVKIFNKH ASDLYIHRLL RQELVVLGRL
1960 1970 1980 1990 2000
HHPSLVGLLA AGAAPHLLVM ELAPRGSLDS LFEHENSSLN RKLQHRIALQ
2010 2020 2030 2040 2050
VADGLRYLHS SMIIYRDLKP HNVLLFNLKT DSETIAKITD YGIAQCCCSM
2060 2070 2080 2090 2100
GVRSSEGTPG FRAPEVARGN VIYNQQADVF SFGLLLYDLL TCGERISDGM
2110 2120 2130 2140 2150
KFPSEFDEIA VQRKLPDPVK HHGCSPWPGF QGLMKDCMRE NPQDRPTSTQ
2160 2170 2180 2190 2200
VFERLNSGEM LCLMRELVVS RAANAECFTV GCSSASNGPS SNPRAWVGGG
2210 2220 2230 2240 2250
SSTQRLGCVA SVDLETEKVT TQVIDTSPVL CLVTVQVPDE ACDWLVAGTQ
2260 2270 2280 2290 2300
SGALVVISTQ NLSNWYNLQS VTDAVTSLFF HTHPQRSQRK NYLLVGTANG
2310 2320 2330 2340 2350
ILTVYEDSAL QVENGQPVKT LHIGNVNTPV MCLGQSGHSL DRTTVWAGCG
2360 2370 2380 2390 2400
TRILSFTADY GVCKTIDTKP NSLFQQHHAV SSEPCVSRMV VEKHVYLSKA
2410 2420 2430 2440 2450
GGQSVEVWNK KSGRMIDSID CAQLLRHNSS RRPRKANSEF EFGADTPTWA
2460 2470 2480 2490 2500
NIKSLLVQQT TTTLWIGTRG GHLLLVELAN LQLLQVISPH CQSIRSMASV
2510 2520 2530 2540 2550
FIETLNRKNV VLVLGRRLSQ DKNQYDEESV LMVWNSSLPL EVKDLNKHCE
2560
MREEITAKMR EQQND
Length:2,565
Mass (Da):285,989
Last modified:April 12, 2017 - v1
Checksum:iB2A46D26BC92239A
GO

Sequence databases

RefSeqiXP_013981177.1, XM_014125702.1

Genome annotation databases

GeneIDi106561594
KEGGisasa:106561594

Similar proteinsi

Entry informationi

Entry nameiA0A1S3KRD5_SALSA
AccessioniPrimary (citable) accession number: A0A1S3KRD5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: February 28, 2018
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health