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Protein

Fibroblast growth factor receptor

Gene

Fgfr3

Organism
Dipodomys ordii (Ord's kangaroo rat)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei707Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotationImported, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:Fgfr3Imported
OrganismiDipodomys ordii (Ord's kangaroo rat)Imported
Taxonomic identifieri10020 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaCastorimorphaHeteromyidaeDipodomyinaeDipodomys
Proteomesi
  • UP000081671 Componenti: Genome assembly

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei462 – 486HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini162 – 237Ig-likeInterPro annotationAdd BLAST76
Domaini279 – 317Ig-likeInterPro annotationAdd BLAST39
Domaini342 – 431Ig-likeInterPro annotationAdd BLAST90
Domaini562 – 851Protein kinaseInterPro annotationAdd BLAST290

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR016248 FGF_rcpt_fam
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PIRSFiPIRSF000628 FGFR, 2 hits
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1S3FRY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRGALRDRG SPRERAQAAG VRRLRMPHTG PSNSSWQQLA TSGGHAALVS
60 70 80 90 100
APAPASTARL QLGLCPPPVL CARRVSLGSP TDPPGPPLTP SGPPLIPQFS
110 120 130 140 150
YSDHSEAGGR AGKCQGSGSL GTAPPWFEQR VEACRPAVCL QSGGAGVRGA
160 170 180 190 200
AWALASRLPI SPTEVPGPEP GQQEQVTFGS GDAVELRCRS PGGGPVGPTV
210 220 230 240 250
WVKDGMGLVS SPRILVGPQR LRVLNASQDD AGAYSCRQRL TQRVLCRFSV
260 270 280 290 300
RVTDTPSSGD DEDGEDMAED TGAPYWTRPE RMEKKLLAVP AANTVRFRCP
310 320 330 340 350
AAGNPTPTIS WLKNGKEFRG EHRIGGIKVG LAGVAERSPH RPILQAGLPA
360 370 380 390 400
NQTAVLGSDV EFHCKVYSDA QPHIQWLKHV EVNGSKVGPD GTPYVTVLKS
410 420 430 440 450
WISEHVEADA RLRLANVSER DGGEYLCRAT NFIGVSEKAF WLRVHGPRAA
460 470 480 490 500
EELVEADEAG SVYAGILSYG VGFFLFILLV ATVTLCRLRT PPKKGLGSPA
510 520 530 540 550
LHKVARFPLK RQVSLESSSS MNSNTPLVRI ARLSSGDGPV LANVSELELP
560 570 580 590 600
ADPKWELSRA QLTLGKPLGE GCFGQVVMAE AIGIDKDRAA KPVTVAVKML
610 620 630 640 650
KDDATDKDLS DLVSEMEMMK MIGKHKNIIN LLGACTQGGP LYVLVEYAAK
660 670 680 690 700
GNLREFLRAR RPPGMDYSFD ACRLPEEQLT FKDLVSCAYQ VARGMEYLAS
710 720 730 740 750
QKCIHRDLAA RNVLVTEDTV MKIADFGLAR DVHNLDYYKK TTNGRLPVKW
760 770 780 790 800
MAPEALFDRV YTHQSDVWSF GVLLWEIFTL GGSPYPGIPV EELFKLLKEG
810 820 830 840 850
HRMDKPANCT HDLYMIMREC WHAAPSQRPT FKQLVEDLDR ILTVTSTDEY
860 870 880 890
LDLSVPFEQY SPGGQDTPSS SSSGDDSVFT HDLLSPAPPS SGGPQT
Length:896
Mass (Da):96,983
Last modified:April 12, 2017 - v1
Checksum:iB051C89337273267
GO

Sequence databases

RefSeqiXP_012879326.1, XM_013023872.1

Genome annotation databases

GeneIDi105991261

Similar proteinsi

Entry informationi

Entry nameiA0A1S3FRY9_DIPOR
AccessioniPrimary (citable) accession number: A0A1S3FRY9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: February 28, 2018
This is version 9 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health