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Protein
Submitted name:

leucine-rich repeat serine/threonine-protein kinase 2 isoform X2

Gene

Lrrk2

Organism
Dipodomys ordii (Ord's kangaroo rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionKinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
leucine-rich repeat serine/threonine-protein kinase 2 isoform X2Imported
Gene namesi
Name:Lrrk2Imported
OrganismiDipodomys ordii (Ord's kangaroo rat)Imported
Taxonomic identifieri10020 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaCastorimorphaHeteromyidaeDipodomyinaeDipodomys
Proteomesi
  • UP000081671 Componenti: Genome assembly

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1330 – 1513RocInterPro annotationAdd BLAST184
Domaini1881 – 2148Protein kinaseInterPro annotationAdd BLAST268

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili327 – 347Sequence analysisAdd BLAST21
Coiled coili2506 – 2529Sequence analysisAdd BLAST24

Keywords - Domaini

Coiled coilSequence analysis, Leucine-rich repeatSAAS annotation, RepeatSAAS annotation

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
1.25.40.20. 1 hit.
2.130.10.10. 2 hits.
3.80.10.10. 4 hits.
InterProiView protein in InterPro
IPR036770. Ankyrin_rpt-contain_sf.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR032171. COR.
IPR011009. Kinase-like_dom_sf.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR032675. LRR_dom_sf.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR020859. ROC_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR005225. Small_GTP-bd_dom.
IPR015943. WD40/YVTN_repeat-like_dom_sf.
IPR036322. WD40_repeat_dom_sf.
PfamiView protein in Pfam
PF16095. COR. 1 hit.
PF12799. LRR_4. 1 hit.
PF13855. LRR_8. 1 hit.
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00369. LRR_TYP. 7 hits.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF50978. SSF50978. 2 hits.
SSF52058. SSF52058. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51450. LRR. 11 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS51424. ROC. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1S3FE68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGSCQGCE EEDEETLKKL LVRLNNVQEG KQIETLVQIL EDILVFTYCD
60 70 80 90 100
HASKLFEGKN FHVPLLIVLD SYMRVASVQQ VGWSLLCKLI EVCPDTLQSL
110 120 130 140 150
MGPQDVGNDW EVLGIHQLIL KMLTVHHANV NLSTVGLKAL ELLLTSGKIT
160 170 180 190 200
LLILDEESDI FLLIFDAMNT FSANEEVQKL GCKALHVLFE RVSEEQLIEF
210 220 230 240 250
VENKDYRILL SALQNFKGEE EIVLHVLHCL HSLAVPCSNV EVLMSGNVRC
260 270 280 290 300
YNIVIDAMRA FPIHEKIQQV SCCLLHRLTL GNFFNILVLN EVHEFVVKAV
310 320 330 340 350
ERYPKNAVLQ ISALSCLALL TETIFLNQDL EEKNETPESE KEEEEEEQEK
360 370 380 390 400
LFWLEACYRA LTWHRKNKHV QEAACWALNN LLMYQNGLHK KIGDEDDQFP
410 420 430 440 450
AHREVMLAML MHSCSKEVFQ ASATALSTLL EQNVNFRKIL LSKGIYLNVL
460 470 480 490 500
ELMQKHIHSP EVAESGCKML NHLFEGSNTS LDTMAVVVPK IITIMKNHQT
510 520 530 540 550
SLSVQLEALR AIVHFIVPGM PDVSRDEFQR KLNMVKKQSF RNDIYKLVLS
560 570 580 590 600
ALNRFIGNPG IQRCGLKVIS SLAHFPDVLE MLSLDGAVDS VLHTLQMYPD
610 620 630 640 650
DQEVQCLGLQ LLGCLSTKKN ICIGTGHLLA KILVSSLQRF KDVLEVQIIG
660 670 680 690 700
FQTILAILDL SEPFSKLLLH HSFESVIFHQ MSLGITEPKG PQFLNLCCKC
710 720 730 740 750
FAKLVMDPEL KSVMLQRACD QNNSIMVECL LLLGADANQA KEATSLICQV
760 770 780 790 800
CERESSPKLV ELLLNSGSRE QDVRKALMIS MQKGDSHIIS LLLRRLALDL
810 820 830 840 850
ANNSICLGGF GIGKIEPSWL APLFPDKISN LRKQTNMGSM LARMVLRHQM
860 870 880 890 900
RSTVEEGAAA GSDENFSEDV LDKLGEWTFI PDSSMDSVFG QSDDLDSEGS
910 920 930 940 950
ESSFLVKKKS NSISVGEFYR DPALQRCSPN LQRHSNSLGP VFDHEDMLKR
960 970 980 990 1000
KIKILSSDDS VRSSKLPSHM RHSDSISSLA SEREYITALD LSANELRDID
1010 1020 1030 1040 1050
ALSQKCCISG HLEHLEKLEL HQNALTNFPQ QLCETLKCLT HLDLHSNKFT
1060 1070 1080 1090 1100
SFPSYLLKMS CLAHLDASRN DIGLPVVLDP ALKCPTLKQF NLSYNQLSSV
1110 1120 1130 1140 1150
PENLAEAVEK LEQLILEGNK ISEICSPLSL KELKVLNLSK NNISSLPENF
1160 1170 1180 1190 1200
LKACPKVESF SARMNFLAAL PFLPSSVTSL KLSQNKFTCV PDVILNLPHL
1210 1220 1230 1240 1250
RSLDMSSNDI ESLPGPSHWK SLNLRELLFS YNQISILDLS EKAHTWSRVE
1260 1270 1280 1290 1300
KLHLSHNKLK EIPPEIGCLE NLTSLDVSYN LELRSFPNEM GKLSKIWDLP
1310 1320 1330 1340 1350
LDELRLNFDF KHVGCKAKDI IRFLQQRLKK AVPYNRMKLM IVGNTGSGKT
1360 1370 1380 1390 1400
TLLQQLMKTK KSDLGIQGAT VGIDVKDWPI QIRGKKKKDL ILNVWDFAGR
1410 1420 1430 1440 1450
EEFYSTHPHF MTQRALYLAV YDLSKGQAEV DAMKPWLFNI KARASSSPVI
1460 1470 1480 1490 1500
LVGTHLDVSD EKQRKACIGK ITKELLNKRG FPAIRDYHCV NATEESDALA
1510 1520 1530 1540 1550
KLRKTIINES LNFKIRDQPV VGQLIPDCYV ELEKIILSER KNVPIEFPVI
1560 1570 1580 1590 1600
DRKRLLQLVK ENQLQLDENE LPHAVHFLNE SGVLLHFQDP ALQLSDLYFV
1610 1620 1630 1640 1650
DPKWLCKVMA QILTVKVEGY PKHPKGIISR KDVEKFLSKK KRFPKNYMIQ
1660 1670 1680 1690 1700
YFKLLEKFQI ALPLGEEYLL VPSSLSDHRP VIELPHCENS EIIIRLYEMP
1710 1720 1730 1740 1750
YFPMGFWSRL INRLLEISPY MLSGRERALR PNRMYWRQGI YLNWSPEAYC
1760 1770 1780 1790 1800
LVRSEILDNH PESFLKIIVP SCRKGCILLG QVVDHIDSLM EEWFPGLLEI
1810 1820 1830 1840 1850
DICGEGETLL KKWALYSFND GEDHQKILLD DLMKKAEEGD LLVNPDQPRL
1860 1870 1880 1890 1900
TIPISQIAPD LILADLPRNI MLNNDELEFE QAPEFLLGDG SFGSVYRAAY
1910 1920 1930 1940 1950
EGEEVAVKIF NKHTSLRLLR QELVVLCHLH HPSLISLLAA GIRPRMLVME
1960 1970 1980 1990 2000
LASRGSLDRL LQQDKASLTR TLQHRIALHV ADGLRYLHSA MIIYRDLKPH
2010 2020 2030 2040 2050
NVLLFTLYPN AAIIAKIADY GIAQYCCRMG IKTSEGTPGF RAPEVARGNV
2060 2070 2080 2090 2100
IYNQQADVYS FGLLLYDILT AGGRIVEGLK FPNEFDELAL QGKLPDPVKE
2110 2120 2130 2140 2150
YGCTPWPMVE KLIKKCLKEN PQERPTSAQV FDILNSAELI CLMKHISIPE
2160 2170 2180 2190 2200
NIIAECMVAT NSNGKNVSIW LGCGHSDKGQ LSFLDLNTEE HITEEVTDSR
2210 2220 2230 2240 2250
ILCLAFVHLP AEKESWIVSG TQSGLLLVID AEDRTKRHSL EKMTDSITCL
2260 2270 2280 2290 2300
YCNCFSKQSK QKNFLLVGTA NGNLAIFEDK AVKCNGAAPL KTLSLGDAST
2310 2320 2330 2340 2350
PLMCLSESMI SSEKHIMWGA CGTKVFSFSN DFSVQKLIET RTNQLFSYAA
2360 2370 2380 2390 2400
FSDSNIIAVA VDTALYVAKK NSPVVEVWDK KTEKLCELID CVQFLKEVMI
2410 2420 2430 2440 2450
KISKESKHNL CYAGRVKALC LQKNTALWIG TGGGHILLLD LSTRRIIRII
2460 2470 2480 2490 2500
NNFCDSVRVM VTAQLGSLKN VMLVLGYKQK STEGTQQQKE IQSCLSIWDI
2510 2520
NLPHEVQNLE KHIEMRKELA EKMRKTSIE
Length:2,529
Mass (Da):285,679
Last modified:April 12, 2017 - v1
Checksum:i00758BD5544E5023
GO

Sequence databases

RefSeqiXP_012874267.1. XM_013018813.1.

Genome annotation databases

GeneIDi105987537.

Similar proteinsi

Entry informationi

Entry nameiA0A1S3FE68_DIPOR
AccessioniPrimary (citable) accession number: A0A1S3FE68
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: December 20, 2017
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported