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Protein
Submitted name:

leucine-rich repeat serine/threonine-protein kinase 2 isoform X3

Gene

Lrrk2

Organism
Dipodomys ordii (Ord's kangaroo rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionKinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
leucine-rich repeat serine/threonine-protein kinase 2 isoform X3Imported
Gene namesi
Name:Lrrk2Imported
OrganismiDipodomys ordii (Ord's kangaroo rat)Imported
Taxonomic identifieri10020 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaCastorimorphaHeteromyidaeDipodomyinaeDipodomys
Proteomesi
  • UP000081671 Componenti: Genome assembly

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1320 – 1503RocInterPro annotationAdd BLAST184
Domaini1871 – 2138Protein kinaseInterPro annotationAdd BLAST268

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili327 – 347Sequence analysisAdd BLAST21
Coiled coili2497 – 2520Sequence analysisAdd BLAST24

Keywords - Domaini

Coiled coilSequence analysis, Leucine-rich repeatSAAS annotation, RepeatSAAS annotation

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
1.25.40.20. 1 hit.
2.130.10.10. 1 hit.
3.80.10.10. 4 hits.
InterProiView protein in InterPro
IPR036770. Ankyrin_rpt-contain_sf.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR032171. COR.
IPR011009. Kinase-like_dom_sf.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR032675. LRR_dom_sf.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR020859. ROC_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR005225. Small_GTP-bd_dom.
IPR015943. WD40/YVTN_repeat-like_dom_sf.
IPR036322. WD40_repeat_dom_sf.
PfamiView protein in Pfam
PF16095. COR. 1 hit.
PF12799. LRR_4. 1 hit.
PF13855. LRR_8. 1 hit.
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00369. LRR_TYP. 7 hits.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF50978. SSF50978. 2 hits.
SSF52058. SSF52058. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51450. LRR. 11 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS51424. ROC. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1S3FCD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGSCQGCE EEDEETLKKL LVRLNNVQEG KQIETLVQIL EDILVFTYCD
60 70 80 90 100
HASKLFEGKN FHVPLLIVLD SYMRVASVQQ VGWSLLCKLI EVCPDTLQSL
110 120 130 140 150
MGPQDVGNDW EVLGIHQLIL KMLTVHHANV NLSTVGLKAL ELLLTSGKIT
160 170 180 190 200
LLILDEESDI FLLIFDAMNT FSANEEVQKL GCKALHVLFE RVSEEQLIEF
210 220 230 240 250
VENKDYRILL SALQNFKGEE EIVLHVLHCL HSLAVPCSNV EVLMSGNVRC
260 270 280 290 300
YNIVIDAMRA FPIHEKIQQV SCCLLHRLTL GNFFNILVLN EVHEFVVKAV
310 320 330 340 350
ERYPKNAVLQ ISALSCLALL TETIFLNQDL EEKNETPESE KEEEEEEQEK
360 370 380 390 400
LFWLEACYRA LTWHRKNKHV QEAACWALNN LLMYQNGLHK KIGDEDDQFP
410 420 430 440 450
AHREVMLAML MHSCSKEVFQ ASATALSTLL EQNGIYLNVL ELMQKHIHSP
460 470 480 490 500
EVAESGCKML NHLFEGSNTS LDTMAVVVPK IITIMKNHQT SLSVQLEALR
510 520 530 540 550
AIVHFIVPGM PDVSRDEFQR KLNMVKKQSF RNDIYKLVLS ALNRFIGNPG
560 570 580 590 600
IQRCGLKVIS SLAHFPDVLE MLSLDGAVDS VLHTLQMYPD DQEVQCLGLQ
610 620 630 640 650
LLGCLSTKKN ICIGTGHLLA KILVSSLQRF KDVLEVQIIG FQTILAILDL
660 670 680 690 700
SEPFSKLLLH HSFESVIFHQ MSLGITEPKG PQFLNLCCKC FAKLVMDPEL
710 720 730 740 750
KSVMLQRACD QNNSIMVECL LLLGADANQA KEATSLICQV CERESSPKLV
760 770 780 790 800
ELLLNSGSRE QDVRKALMIS MQKGDSHIIS LLLRRLALDL ANNSICLGGF
810 820 830 840 850
GIGKIEPSWL APLFPDKISN LRKQTNMGSM LARMVLRHQM RSTVEEGAAA
860 870 880 890 900
GSDENFSEDV LDKLGEWTFI PDSSMDSVFG QSDDLDSEGS ESSFLVKKKS
910 920 930 940 950
NSISVGEFYR DPALQRCSPN LQRHSNSLGP VFDHEDMLKR KIKILSSDDS
960 970 980 990 1000
VRSSKLPSHM RHSDSISSLA SEREYITALD LSANELRDID ALSQKCCISG
1010 1020 1030 1040 1050
HLEHLEKLEL HQNALTNFPQ QLCETLKCLT HLDLHSNKFT SFPSYLLKMS
1060 1070 1080 1090 1100
CLAHLDASRN DIGLPVVLDP ALKCPTLKQF NLSYNQLSSV PENLAEAVEK
1110 1120 1130 1140 1150
LEQLILEGNK ISEICSPLSL KELKVLNLSK NNISSLPENF LKACPKVESF
1160 1170 1180 1190 1200
SARMNFLAAL PFLPSSVTSL KLSQNKFTCV PDVILNLPHL RSLDMSSNDI
1210 1220 1230 1240 1250
ESLPGPSHWK SLNLRELLFS YNQISILDLS EKAHTWSRVE KLHLSHNKLK
1260 1270 1280 1290 1300
EIPPEIGCLE NLTSLDVSYN LELRSFPNEM GKLSKIWDLP LDELRLNFDF
1310 1320 1330 1340 1350
KHVGCKAKDI IRFLQQRLKK AVPYNRMKLM IVGNTGSGKT TLLQQLMKTK
1360 1370 1380 1390 1400
KSDLGIQGAT VGIDVKDWPI QIRGKKKKDL ILNVWDFAGR EEFYSTHPHF
1410 1420 1430 1440 1450
MTQRALYLAV YDLSKGQAEV DAMKPWLFNI KARASSSPVI LVGTHLDVSD
1460 1470 1480 1490 1500
EKQRKACIGK ITKELLNKRG FPAIRDYHCV NATEESDALA KLRKTIINES
1510 1520 1530 1540 1550
LNFKIRDQPV VGQLIPDCYV ELEKIILSER KNVPIEFPVI DRKRLLQLVK
1560 1570 1580 1590 1600
ENQLQLDENE LPHAVHFLNE SGVLLHFQDP ALQLSDLYFV DPKWLCKVMA
1610 1620 1630 1640 1650
QILTVKVEGY PKHPKGIISR KDVEKFLSKK KRFPKNYMIQ YFKLLEKFQI
1660 1670 1680 1690 1700
ALPLGEEYLL VPSSLSDHRP VIELPHCENS EIIIRLYEMP YFPMGFWSRL
1710 1720 1730 1740 1750
INRLLEISPY MLSGRERALR PNRMYWRQGI YLNWSPEAYC LVRSEILDNH
1760 1770 1780 1790 1800
PESFLKIIVP SCRKGCILLG QVVDHIDSLM EEWFPGLLEI DICGEGETLL
1810 1820 1830 1840 1850
KKWALYSFND GEDHQKILLD DLMKKAEEGD LLVNPDQPRL TIPISQIAPD
1860 1870 1880 1890 1900
LILADLPRNI MLNNDELEFE QAPEFLLGDG SFGSVYRAAY EGEEVAVKIF
1910 1920 1930 1940 1950
NKHTSLRLLR QELVVLCHLH HPSLISLLAA GIRPRMLVME LASRGSLDRL
1960 1970 1980 1990 2000
LQQDKASLTR TLQHRIALHV ADGLRYLHSA MIIYRDLKPH NVLLFTLYPN
2010 2020 2030 2040 2050
AAIIAKIADY GIAQYCCRMG IKTSEGTPGF RAPEVARGNV IYNQQADVYS
2060 2070 2080 2090 2100
FGLLLYDILT AGGRIVEGLK FPNEFDELAL QGKLPDPVKE YGCTPWPMVE
2110 2120 2130 2140 2150
KLIKKCLKEN PQERPTSAQV FDILNSAELI CLMKHISIPE NIIAECMVAT
2160 2170 2180 2190 2200
NSNGKNVSIW LGCGHSDKGQ LSFLDLNTEE HITEQEVTDS RILCLAFVHL
2210 2220 2230 2240 2250
PAEKESWIVS GTQSGLLLVI DAEDRTKRHS LEKMTDSITC LYCNCFSKQS
2260 2270 2280 2290 2300
KQKNFLLVGT ANGNLAIFED KAVKCNGAAP LKTLSLGDAS TPLMCLSESM
2310 2320 2330 2340 2350
ISSEKHIMWG ACGTKVFSFS NDFSVQKLIE TRTNQLFSYA AFSDSNIIAV
2360 2370 2380 2390 2400
AVDTALYVAK KNSPVVEVWD KKTEKLCELI DCVQFLKEVM IKISKESKHN
2410 2420 2430 2440 2450
LCYAGRVKAL CLQKNTALWI GTGGGHILLL DLSTRRIIRI INNFCDSVRV
2460 2470 2480 2490 2500
MVTAQLGSLK NVMLVLGYKQ KSTEGTQQQK EIQSCLSIWD INLPHEVQNL
2510 2520
EKHIEMRKEL AEKMRKTSIE
Length:2,520
Mass (Da):284,607
Last modified:April 12, 2017 - v1
Checksum:i472D4A176417E0EF
GO

Sequence databases

RefSeqiXP_012874268.1. XM_013018814.1.

Genome annotation databases

GeneIDi105987537.

Similar proteinsi

Entry informationi

Entry nameiA0A1S3FCD5_DIPOR
AccessioniPrimary (citable) accession number: A0A1S3FCD5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: December 20, 2017
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported