Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA topoisomerase 2

Gene

Top2b

Organism
Dipodomys ordii (Ord's kangaroo rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, Isomerase, TopoisomeraseUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomerase 2UniRule annotation (EC:5.99.1.3UniRule annotation)
Gene namesi
Name:Top2bImported
OrganismiDipodomys ordii (Ord's kangaroo rat)Imported
Taxonomic identifieri10020 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaCastorimorphaHeteromyidaeDipodomyinaeDipodomys
Proteomesi
  • UP000081671 Componenti: Genome assembly

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 66HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini581 – 698ToprimInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the type II topoisomerase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

CDDicd00075. HATPase_c. 1 hit.
cd03365. TOPRIM_TopoIIA. 1 hit.
Gene3Di1.10.268.10. 1 hit.
3.30.1360.40. 1 hit.
3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
3.40.50.670. 1 hit.
3.90.199.10. 1 hit.
InterProiView protein in InterPro
IPR024946. Arg_repress-like_C.
IPR012542. DTHCT.
IPR003594. HATPase_C.
IPR036890. HATPase_C_sf.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR001241. Topo_IIA.
IPR013760. Topo_IIA-like_dom_sf.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a_sf.
IPR013759. Topo_IIA_B_C.
IPR013506. Topo_IIA_bsu_dom2.
IPR018522. TopoIIA_CS.
IPR031660. TOPRIM_C.
IPR006171. TOPRIM_domain.
IPR034157. TOPRIM_TopoII.
PANTHERiPTHR10169. PTHR10169. 1 hit.
PfamiView protein in Pfam
PF00204. DNA_gyraseB. 1 hit.
PF00521. DNA_topoisoIV. 1 hit.
PF08070. DTHCT. 1 hit.
PF02518. HATPase_c. 1 hit.
PF01751. Toprim. 1 hit.
PF16898. TOPRIM_C. 1 hit.
SMARTiView protein in SMART
SM00433. TOP2c. 1 hit.
SM00434. TOP4c. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
SSF56719. SSF56719. 1 hit.
PROSITEiView protein in PROSITE
PS00177. TOPOISOMERASE_II. 1 hit.
PS50880. TOPRIM. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1S3EN64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVLEGDAVD FEKTVPVVFA STMAQAWIRA GPEERWSRAG VLYFFIAPIT
60 70 80 90 100
FVLDLGFTFA QLYFALEAWL SNTSKRFCGE RTHENAQKGA LKNESEMVKF
110 120 130 140 150
QHLSYLDDED YVLLHDASIM TLNSIFEQTL FDQNNAAKKE ESEIANKNDS
160 170 180 190 200
SKKLSVERVY QKKTQLEHIL LRPDTYIGSV EPLTQLMWVY DEDVGMNCRE
210 220 230 240 250
VTFVPGLYKI FDEILVNAAD NKQRDKNMTC IKVSIDPESN IISIWNNGKG
260 270 280 290 300
IPVVEHKVEK VYVPALIFGQ LLTSSNYDDD EKKVTGGRNG YGAKLCNIFS
310 320 330 340 350
TKFTVETACK EYKHSFKQTW MNNMMKTSEA KIKHFDGEDY TCITFQPDLS
360 370 380 390 400
KFKMEKLDKD IVALMTRRAY DLAGSCKGVK VMFNGKKLPV NGFRSYVDLY
410 420 430 440 450
VKDKLDETGV ALKVIHELAN ERWDVCLTLS EKGFQQISFV NSIATTKGGR
460 470 480 490 500
HVDYVVDQVV GKLIEVVKKK NKAGVSVKPF QVKNHIWVFI NCLIENPTFD
510 520 530 540 550
SQTKENMTLQ PKSFGSKCQL SEKFFKAASN CGIVESILNW VKFKAQTQLN
560 570 580 590 600
KKCSSVKYSK IKGIPKLDDA NDAGGKHSLE CTLILTEGDS AKSLAVSGLG
610 620 630 640 650
VIGRDRYGVF PLRGKILNVR EASHKQIMEN AEINNIIKIV GLQYKKSYDD
660 670 680 690 700
AESLKTLRYG KIMIMTDQDQ DGSHIKGLLI NFIHHNWPSL LKHGFLEEFI
710 720 730 740 750
TPIVKASKNK QELSFYSIPE FDEWKKHIEN QKAWKIKYYK GLGTSTAKEA
760 770 780 790 800
KEYFADMERH RILFRYAGPE DDAAITLAFS KKKIDDRKEW LTNFMEDRRQ
810 820 830 840 850
RRLHGLPEQF LYGTATKHLT YNDFINKELI LFSNSDNERS IPSLVDGFKP
860 870 880 890 900
GQRKVLFTCF KRNDKREVKV AQLAGSVAEM SAYHHGEQAL MMTIVNLAQN
910 920 930 940 950
FVGSNNINLL QPIGQFGTRL HGGKDAASPR YIFTMLSSLA RLLFPAVDDN
960 970 980 990 1000
LLKFLYDDNQ RVEPEWYIPI IPMVLINGAE GIGTGWACKL PNYDAREIVN
1010 1020 1030 1040 1050
NVRRMLEGLD PHPMLPNYKN FKGTIQELGQ NQYAVSGEIF VVDRNTVEIT
1060 1070 1080 1090 1100
ELPVRTWTQV YKEQVLEPML NGTDKTPALI SDYKEYHTDT TVKFVVKMTE
1110 1120 1130 1140 1150
EKLAQAEAAG LHKVFKLQTT LTCNSMVLFD HMGCLKKYET VQDILKEFFD
1160 1170 1180 1190 1200
LRLSYYGLRK EWLVGMLGAE STKLNNQARF ILEKIQGKIT IENRSKKDLI
1210 1220 1230 1240 1250
QMLVQRGYES DPVKAWKEAQ EKAAEEEETQ NQHDDSSSDS GTPSGPDFNY
1260 1270 1280 1290 1300
ILNMSLWSLT KEKVEELIKQ RDTKGREVND LKRKSPSDLW KEDLAAFVEE
1310 1320 1330 1340 1350
LDKVEAQERE DILAGMSGKA IKGKVGKPKV KKLQLEETMP SPYGRRIIPE
1360 1370 1380 1390 1400
ITAMKADASK KLLKKKKGDS DTTAVKVEFD EEFSGTPVEG IGEEALTPAA
1410 1420 1430 1440 1450
PINKGPKPKR EKKEPGTRVR KTPTTTGKPG AKKVKKRNPW SDDESKSESD
1460 1470 1480 1490 1500
LEETEPVVIP RDSLLRRAAA ERPKYTFDFS EEEDDDADDD DDNNDLEELK
1510 1520 1530 1540 1550
VKASPIMNDG EDDFVPSDGL DKDEYTFSPG KSKATPEKSS HDKKGQDFGN
1560 1570 1580 1590 1600
LFSFTSYSQK SEDDSAKFDS NEEDTASVFS PSFGLKQADK VPSKTVAAKK
1610 1620 1630 1640 1650
GKPSSDIAPK PKRAPKQKKV VETINSDSDS EFGIPKKTTA PKGKGRGAKK
1660 1670 1680 1690 1700
RKASGSENEG DYNPGRKTSK PASKKPKKTA FDQDSDVDIF PSDFTSEPPS
1710 1720
LPRTGRARKE VKYFAESDEE EDVDFAMFN
Length:1,729
Mass (Da):195,618
Last modified:April 12, 2017 - v1
Checksum:iEB9913D2C0AD4FCC
GO

Sequence databases

RefSeqiXP_012865828.1. XM_013010374.1.

Genome annotation databases

GeneIDi105981283.

Similar proteinsi

Entry informationi

Entry nameiA0A1S3EN64_DIPOR
AccessioniPrimary (citable) accession number: A0A1S3EN64
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: November 22, 2017
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported