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Protein

Purine nucleoside phosphorylase

Gene

PNP

Organism
Erinaceus europaeus (Western European hedgehog)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.UniRule annotation

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: purine nucleoside salvage

This protein is involved in the pathway purine nucleoside salvage, which is part of Purine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway purine nucleoside salvage and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33PhosphateUniRule annotation1
Binding sitei64PhosphateUniRule annotation1
Binding sitei116Phosphate; via amide nitrogenUniRule annotation1
Binding sitei202Purine nucleosideUniRule annotation1
Binding sitei221PhosphateUniRule annotation1
Binding sitei244Purine nucleosideUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

UniPathwayiUPA00606.

Names & Taxonomyi

Protein namesi
Recommended name:
Purine nucleoside phosphorylaseUniRule annotation (EC:2.4.2.1UniRule annotation)
Alternative name(s):
Inosine-guanosine phosphorylaseUniRule annotation
Gene namesi
Name:PNPImported
OrganismiErinaceus europaeus (Western European hedgehog)Imported
Taxonomic identifieri9365 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraErinaceidaeErinaceinaeErinaceus
Proteomesi
  • UP000079721 Componenti: Genome assembly

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 276PNP_UDP_1InterPro annotationAdd BLAST250

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 86Phosphate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family.UniRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR000845. Nucleoside_phosphorylase_d.
IPR035994. Nucleoside_phosphorylase_sf.
IPR011270. Pur_Nuc_Pase_Ino/Guo-sp.
IPR011268. Purine_phosphorylase.
IPR018099. Purine_phosphorylase-2_CS.
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiView protein in Pfam
PF01048. PNP_UDP_1. 1 hit.
PIRSFiPIRSF000477. PurNPase. 1 hit.
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01700. PNPH. 1 hit.
TIGR01697. PNPH-PUNA-XAPA. 1 hit.
PROSITEiView protein in PROSITE
PS01240. PNP_MTAP_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1S3ANF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESGVTYEDY EETANWLLSH TSHRPQVAVI CGSGLGGLIN KLTQAQVFDY
60 70 80 90 100
SDIPHFPRST VPGHAGRLVF GFLSGRACVM MQGRFHMYEG YPLSKVTFPV
110 120 130 140 150
RVFCLLGVNI LVVTNAAGGL NPKFEVGDIM LIRDHINLPG FCGQNPLRGP
160 170 180 190 200
NEERFGVRFP AMSDAYDRDI RLLAHSTWKQ MENQHRELQE GTYVMLAGPN
210 220 230 240 250
FETVAESRLL KQLGADAVGM STVPEVIVAR HCGLRVFGFS LITNKVIMDY
260 270 280 290
DSIEKANHEE VLEAGKQAAQ KLEEFISILM ENIPQGGSAS
Length:290
Mass (Da):32,089
Last modified:April 12, 2017 - v1
Checksum:i3FD77E4812F32A2F
GO

Sequence databases

RefSeqiXP_007538023.1. XM_007537961.1.

Genome annotation databases

GeneIDi103127026.

Similar proteinsi

Entry informationi

Entry nameiA0A1S3ANF8_ERIEU
AccessioniPrimary (citable) accession number: A0A1S3ANF8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: October 25, 2017
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported