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Protein
Submitted name:

D(2) dopamine receptor isoform X2

Gene

DRD2

Organism
Erinaceus europaeus (Western European hedgehog)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
D(2) dopamine receptor isoform X2Imported
Gene namesi
Name:DRD2Imported
OrganismiErinaceus europaeus (Western European hedgehog)Imported
Taxonomic identifieri9365 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraErinaceidaeErinaceinaeErinaceus
Proteomesi
  • UP000079721 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei36 – 59HelicalSequence analysisAdd BLAST24
Transmembranei71 – 93HelicalSequence analysisAdd BLAST23
Transmembranei109 – 131HelicalSequence analysisAdd BLAST23
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Transmembranei192 – 216HelicalSequence analysisAdd BLAST25
Transmembranei374 – 395HelicalSequence analysisAdd BLAST22
Transmembranei407 – 429HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 426G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST376

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

InterProiView protein in InterPro
IPR001922. Dopamine_D2_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00567. DOPAMINED2R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1S3AJ66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPLNLSWYD DDLESRNWSR SLNGSEGRGD RPQYNYYAML LTLLIFVIVF
60 70 80 90 100
GNVLVCMAVS REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW
110 120 130 140 150
KFSRIHCDIF VTLDVMMCTA SILNLCAISI DRYTAVAMPM LYNTRYSSKR
160 170 180 190 200
RVTVMIAIVW VLSFTISCPM LFGLNNTDQN ECIIANPAFV VYSSIVSFYV
210 220 230 240 250
PFIVTLLVYI KIYIVLRRRR KRVNTKRSSR AFRANLKAPL KGNCTHPEDL
260 270 280 290 300
KLCTVLMKSN GSFPVNRRRV EAARRAQELE MEMLSSTSPP ERTRYSPIPP
310 320 330 340 350
SHHQLTLPDP SHHGLHSTPD SPAKPEKNGH AKDHPKIAKI FEIQTMPNGK
360 370 380 390 400
TRTSLKTLSR RKLSQQKEKK ATQMLAIVLG VFIICWLPFF ITHILNIHCD
410 420 430 440
CNIPPVLYSA FTWLGYVNSA VNPIIYTTFN IEFRKAFLKI LHC
Length:443
Mass (Da):50,604
Last modified:April 12, 2017 - v1
Checksum:i194438AEF903F183
GO

Sequence databases

RefSeqiXP_007536038.1. XM_007535976.1.

Genome annotation databases

GeneIDi103125104.

Similar proteinsi

Entry informationi

Entry nameiA0A1S3AJ66_ERIEU
AccessioniPrimary (citable) accession number: A0A1S3AJ66
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: August 30, 2017
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported