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Protein
Submitted name:

cadherin-18 isoform X1

Gene

CDH18

Organism
Erinaceus europaeus (Western European hedgehog)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Cadherins are calcium-dependent cell adhesion proteins.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesionUniRule annotationSAAS annotation
LigandCalciumUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
cadherin-18 isoform X1Imported
Gene namesi
Name:CDH18Imported
OrganismiErinaceus europaeus (Western European hedgehog)Imported
Taxonomic identifieri9365 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraErinaceidaeErinaceinaeErinaceus
Proteomesi
  • UP000079721 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei615 – 636HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_501017152725 – 790Sequence analysisAdd BLAST766

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 157CAInterPro annotationAdd BLAST82
Domaini181 – 266CAInterPro annotationAdd BLAST86
Domaini290 – 382CAInterPro annotationAdd BLAST93
Domaini405 – 486CAInterPro annotationAdd BLAST82
Domaini509 – 596CAInterPro annotationAdd BLAST88

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 2 hits

Sequencei

Sequence statusi: Complete.

A0A1S3ACB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKITSTSCIC PVLVCLCFVQ RCYGTAQHSS VKGTRNQTKH IEGETEVHHR
60 70 80 90 100
PKRGWVWNQF FVLEEHMGPD PQYVGKLHSN SDKGDGSVKY ILTGEGAGTI
110 120 130 140 150
FIIDDTTGDI HSTKSLDREQ KTHYVLHAQA IDRRTNKPLE PESEFIIKVQ
160 170 180 190 200
DINDNAPKFT EGPYIVTVPE MSDMGTSVLQ VTATDADDPT YGNSARVVYS
210 220 230 240 250
ILQGQPYFSV DPRTGVIRTA LHNMDREARE HYSVVIQAKD MAGQVGGLSG
260 270 280 290 300
STTVNITLTD VNDNPPRFPQ KHYQLYVPES AQVGSAVGKI KATDADTGSN
310 320 330 340 350
ADMTYSITNG DGIGIFSIST DKETREGILS LKKPLNYEKK KSYTLNIEGA
360 370 380 390 400
NTHLDFRFSH LGPFKDATML KIIVGDVDEP PLFSMPSYVM EVYENAKIGT
410 420 430 440 450
MIGTVLAQDP DSANSVVRYF IDYSADDDRF FNIDANTGTI KTSKVLDREE
460 470 480 490 500
NSWYNITVSA SEHDNPGLLS HVTVGIRVLD VNDNPPELAR EYDIVVCENS
510 520 530 540 550
KPGQVIHTIS ATDKDDFANG PRFNFFLDES RSINPNFTLK DNEDNTASIL
560 570 580 590 600
TRRRRFSRTM QDVYYLPIMI SDGGIPSLSS SSTLTIRVCA CERDGRVRTC
610 620 630 640 650
HAEAFLSSAG LSTGALIAIL LCVVILLAIV VLFITLRRSK KEPLIISEED
660 670 680 690 700
VRENVVTYDD EGGGEEDTEA FDITALRNPS AAEELKYRRD IRPEVKLTPR
710 720 730 740 750
HQTLSTLESI DVQEFIKQRL AEADLDPSVP PYDSLQTYAY EGQRSEAGSI
760 770 780 790
SSLDSATTQS DQDYQYLGDW GPEFKKLAEL YGEIESERTT
Length:790
Mass (Da):87,808
Last modified:April 12, 2017 - v1
Checksum:iA3D4AF708E18FA24
GO

Sequence databases

RefSeqiXP_007532750.1, XM_007532688.1

Genome annotation databases

GeneIDi103122098

Similar proteinsi

Entry informationi

Entry nameiA0A1S3ACB9_ERIEU
AccessioniPrimary (citable) accession number: A0A1S3ACB9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: February 28, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health