Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

UMP-CMP kinase

Gene

CMPK1

Organism
Erinaceus europaeus (Western European hedgehog)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.UniRule annotation

Catalytic activityi

ATP + (d)CMP = ADP + (d)CDP.UniRule annotation
ATP + UMP = ADP + UDP.UniRule annotation
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per monomer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei71NMPUniRule annotation1
Binding sitei132CMPUniRule annotation1
Binding sitei166ATPUniRule annotation1
Binding sitei172NMPUniRule annotation1
Binding sitei183NMPUniRule annotation1
Binding sitei211ATP; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi45 – 50ATPUniRule annotation6
Nucleotide bindingi93 – 95NMPUniRule annotation3
Nucleotide bindingi125 – 128NMPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processPyrimidine biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
UMP-CMP kinaseUniRule annotation (EC:2.7.4.14UniRule annotation)
Alternative name(s):
Deoxycytidylate kinaseUniRule annotation
Short name:
CKUniRule annotation
Short name:
dCMP kinaseUniRule annotation
Nucleoside-diphosphate kinaseUniRule annotation (EC:2.7.4.6UniRule annotation)
Uridine monophosphate/cytidine monophosphate kinaseUniRule annotation
Short name:
UMP/CMP kinaseUniRule annotation
Short name:
UMP/CMPKUniRule annotation
Gene namesi
Name:CMPK1UniRule annotationImported
Synonyms:CMPKUniRule annotation
OrganismiErinaceus europaeus (Western European hedgehog)Imported
Taxonomic identifieri9365 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraErinaceidaeErinaceinaeErinaceus
Proteomesi
  • UP000079721 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni65 – 95NMPbindUniRule annotationAdd BLAST31
Regioni165 – 175LIDUniRule annotationAdd BLAST11

Domaini

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.UniRule annotation

Sequence similaritiesi

Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.UniRule annotation

Family and domain databases

CDDicd01428. ADK. 1 hit.
HAMAPiMF_00235. Adenylate_kinase_Adk. 1 hit.
MF_03172. Adenylate_kinase_UMP_CMP_kin. 1 hit.
InterProiView protein in InterPro
IPR000850. Adenylat/UMP-CMP_kin.
IPR033690. Adenylat_kinase_CS.
IPR027417. P-loop_NTPase.
IPR006266. UMP_CMP_kinase.
PANTHERiPTHR23359. PTHR23359. 1 hit.
PRINTSiPR00094. ADENYLTKNASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01359. UMP_CMP_kin_fam. 1 hit.
PROSITEiView protein in PROSITE
PS00113. ADENYLATE_KINASE. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1S2ZLY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRCGRQLL HIVDLRFPLL SSRPLYLCPH HPMKPLVVFV LGGPGAGKGT
60 70 80 90 100
QCARIVQKYG YVHLSAGELL RDERKNPDSQ YGELIEKYIK DGKIVPVEIT
110 120 130 140 150
ISLLKREMDQ TMAANAQKNK FLIDGFPRNE DNLQGWNKTM DGKADVSFVL
160 170 180 190 200
FFDCNNEICI ERCLERGKSS GRSDDNRESL EKRIETYLQS TKPIIDLYEE
210 220
MGKVKKIDAS KSVDEVFDEV VKIFDKEG
Length:228
Mass (Da):25,959
Last modified:April 12, 2017 - v1
Checksum:iFFE9933136A51CD5
GO

Sequence databases

RefSeqiXP_007521401.1. XM_007521339.1.

Genome annotation databases

GeneIDi103111989.

Similar proteinsi

Entry informationi

Entry nameiA0A1S2ZLY2_ERIEU
AccessioniPrimary (citable) accession number: A0A1S2ZLY2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: September 27, 2017
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported