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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Haemophilus sp. HMSC61B11
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei622ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotation, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotationImported
ORF Names:HMPREF3263_04530Imported
OrganismiHaemophilus sp. HMSC61B11Imported
Taxonomic identifieri1608882 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000179505 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 171tRNA-synt_1InterPro annotationAdd BLAST158
Domaini221 – 404tRNA-synt_1_2InterPro annotationAdd BLAST184
Domaini417 – 572tRNA-synt_1InterPro annotationAdd BLAST156
Domaini618 – 652tRNA-synt_1InterPro annotationAdd BLAST35
Domaini701 – 823Anticodon_1InterPro annotationAdd BLAST123

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionUniRule annotationAdd BLAST11
Motifi619 – 623"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1S1FSA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQHYRPDLI EPAVQQYWAE NKVFKAIKDT SKEKYYCLSM FPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VVSRYQRMNG KNVLQPIGWD AFGLPAEGAA IKNKTAPAKW
110 120 130 140 150
TYENIEYMKK QLKMLGFGYD WDREIATCRP EYYKWEQWFF TELYKKGLVY
160 170 180 190 200
KKTSTVNWCP NDETVLANEQ VHEGCCWRCD TPVEQKEIPQ WFIKITDYAE
210 220 230 240 250
QLLSGLDQLP QWPDMVKTMQ RNWIGRSEGV EITFDVADTA EKVAVYTTRP
260 270 280 290 300
DTFYGVSYLG IAAAHPLADL AAEKNPELAE FIREAKNAKV AEADLATMEK
310 320 330 340 350
KGMATGLFAI HPLTGEKLPI WVANFVLMHY GTGAVMAVPA HDQRDFEFAQ
360 370 380 390 400
KYDLPIKQVI APLADEEIDL TKQAFVEHGK LVNSAEFDGL DFDGAFNGIA
410 420 430 440 450
DKLEKLGVGK RQVNYRLRDW GVSRQRYWGA PIPMLTLPNG ETVPAPIEDL
460 470 480 490 500
PIILPEDVVM DGVKSPIKAD PNWAKTTFNG EPALKETDTF DTFMESSWYY
510 520 530 540 550
ARYTSPSYAE GMLDKEEANY WLPVDQYIGG IEHATMHLLY FRFFHKLLRD
560 570 580 590 600
AGFVTSDEPA QKLLCQGMVL ADAFYYTSPT NERIWVSPTQ VTLERDEKGR
610 620 630 640 650
IIKATDPEGR ELVHTGMTKM SKSKNNGIDP QEMVEKYGAD TVRLFMMFAS
660 670 680 690 700
PAEMTLEWQE SGVEGAKRFL GRVWNLVYEY SQNPAKTALD VTALSAGQKA
710 720 730 740 750
LRRDVHKTIA KVSDDIGRRQ TFNTAIAAVM ELMNKLTRAP LESEQDRAVM
760 770 780 790 800
AEALSAVVRM LYPITPHICF ELWKALGNES NIDHAEWVKA DEAAMVEDEK
810 820 830 840 850
LIVVQVNGKV RGKVTVAADA DEETVKTVAF ADENVKKFTD DTQIVKVIYV
860
PGKLLNVVVK PQ
Length:862
Mass (Da):97,814
Last modified:April 12, 2017 - v1
Checksum:i11C3855D0C0AD27D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LWQR01000018 Genomic DNA Translation: OHR67442.1
RefSeqiWP_070852936.1, NZ_KV837957.1

Similar proteinsi

Entry informationi

Entry nameiA0A1S1FSA6_9PAST
AccessioniPrimary (citable) accession number: A0A1S1FSA6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: March 28, 2018
This is version 9 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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