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Protein

Hypoxanthine phosphoribosyltransferase

Gene

hpt

Organism
Bacillus anthracis
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: IMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from hypoxanthine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Hypoxanthine phosphoribosyltransferase (hpt), Hypoxanthine phosphoribosyltransferase (hpt), Hypoxanthine phosphoribosyltransferase (hpt), Hypoxanthine phosphoribosyltransferase (hpt), Hypoxanthine phosphoribosyltransferase (MCCC1A01412_15175), Hypoxanthine phosphoribosyltransferase (hpt), Hypoxanthine phosphoribosyltransferase (hpt2), Hypoxanthine phosphoribosyltransferase (hpt), Hypoxanthine phosphoribosyltransferase (hpt), Hypoxanthine phosphoribosyltransferase (A9486_14305), Hypoxanthine phosphoribosyltransferase (hpt), Hypoxanthine phosphoribosyltransferase (hpt), Hypoxanthine phosphoribosyltransferase (hpt), Hypoxanthine phosphoribosyltransferase (BVG01_16050), Hypoxanthine phosphoribosyltransferase (hpt), Hypoxanthine phosphoribosyltransferase (hpt)
This subpathway is part of the pathway IMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from hypoxanthine, the pathway IMP biosynthesis via salvage pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotationImported, Transferase
Biological processPurine salvageUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00591; UER00648.

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.8UniRule annotation)
Gene namesi
Name:hptImported
Synonyms:hprTImported, tilSImported
ORF Names:A9486_05730Imported, ABW01_27435Imported, BASH2_00187Imported, BVG01_28865Imported, CN272_24955Imported, CN488_12230Imported, CN504_22375Imported, MCCC1A01412_27610Imported
OrganismiBacillus anthracisImported
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000183215 Componenti: Unassembled WGS sequence
  • UP000181973 Componenti: Unassembled WGS sequence
  • UP000220030 Componenti: Unassembled WGS sequence
  • UP000219912 Componenti: Unassembled WGS sequence
  • UP000219880 Componenti: Unassembled WGS sequence
  • UP000217643 Componenti: Chromosome
  • UP000191148 Componenti: Unassembled WGS sequence
  • UP000035904 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3H83X-ray2.06A/B/C/D1-180[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 160PribosyltranInterPro annotationAdd BLAST146

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UGV. Bacteria.
COG0634. LUCA.
KOiK00760.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
InterProiView protein in InterPro
IPR005904. Hxn_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
PfamiView protein in Pfam
PF00156. Pribosyltran. 1 hit.
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01203. HGPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1S0QLD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNQDIEKVL ISEEQIQEKV LELGAIIAED YKNTVPLAIG VLKGAMPFMA
60 70 80 90 100
DLLKRTDTYL EMDFMAVSSY GHSTVSTGEV KILKDLDTSV EGRDILIVED
110 120 130 140 150
IIDSGLTLSY LVDLFKYRKA KSVKIVTLLD KPTGRKVDLK ADYVGFTVPH
160 170 180
EFVVGYGLDY KEQYRNLPYV GVLKPSVYSN
Length:180
Mass (Da):20,208
Last modified:May 10, 2017 - v1
Checksum:i5A34CE2B632D3566
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP014833 Genomic DNA. Translation: BAR73594.1.
LDPG01000031 Genomic DNA. Translation: KLV14471.1.
LZQW01000103 Genomic DNA. Translation: OJD82914.1.
LZQX01000016 Genomic DNA. Translation: OJD94099.1.
MTAU01000033 Genomic DNA. Translation: OPD54752.1.
NTYQ01000013 Genomic DNA. Translation: PES22947.1.
NTZE01000039 Genomic DNA. Translation: PES78474.1.
NTQV01000027 Genomic DNA. Translation: PFC82912.1.
RefSeqiWP_000981838.1. NZ_NVMW01000023.1.

Genome annotation databases

EnsemblBacteriaiANH84494; ANH84494; A8C77_00370.
KLV14471; KLV14471; ABW01_27435.
KEGGibanh:HYU01_00365.
PATRICifig|1392.230.peg.63.

Similar proteinsi

Entry informationi

Entry nameiA0A1S0QLD4_BACAN
AccessioniPrimary (citable) accession number: A0A1S0QLD4
Secondary accession number(s): E9R985
, Q6I4Y0, Q6KYM4, Q81VX6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2017
Last sequence update: May 10, 2017
Last modified: January 31, 2018
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported