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Protein

Proteasome subunit beta

Gene

psmB_2

Organism
Candidatus Odinarchaeota archaeon LCB_4
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotationSAAS annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotationSAAS annotation

Enzyme regulationi

The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei17NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine proteaseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit betaUniRule annotation (EC:3.4.25.1UniRule annotation)
Alternative name(s):
20S proteasome beta subunitUniRule annotation
Proteasome core protein PsmBUniRule annotation
Gene namesi
Name:psmB_2Imported
Synonyms:psmBUniRule annotation
ORF Names:OdinLCB4_07370Imported
OrganismiCandidatus Odinarchaeota archaeon LCB_4Imported
Taxonomic identifieri1841599 [NCBI]
Taxonomic lineageiArchaeaAsgard groupCandidatus Odinarchaeota
Proteomesi
  • UP000186851 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation, ProteasomeUniRule annotationSAAS annotationImported

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_50103901261 – 16Removed in mature form; by autocatalysisUniRule annotationAdd BLAST16

Keywords - PTMi

Autocatalytic cleavageUniRule annotation, ZymogenUniRule annotation

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_02113_A. Proteasome_B_A. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR019983. Pept_T1A_Psome_bsu_arc.
IPR000243. Pept_T1A_subB.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
PANTHERiPTHR11599:SF108. PTHR11599:SF108. 1 hit.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR03634. arc_protsome_B. 1 hit.
PROSITEiView protein in PROSITE
PS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1Q9N614-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYSEIINDI SKFTTGTTTV GIRCVDGVIL ATDRRATAEY LVASRNAQKI
60 70 80 90 100
YILDDHLAAT IAGAVADAQN IMDIVTAEAK LYKIRSGKPI PVQSASRLLS
110 120 130 140 150
NILFQSRQLP YILQLIIGGF DYTGARLFVL DLFGSLTEEK FTSTGSGSPI
160 170 180 190 200
ALGVLENGYF ENIKVEEAIA LAVHAVNSAI NRDVGSGDGV DVVKITSKGV
210
EKIPQNEVNK YVTRIV
Length:216
Mass (Da):23,313
Last modified:April 12, 2017 - v1
Checksum:iC375EFDD85E3DA17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MDVT01000007 Genomic DNA. Translation: OLS17522.1.

Similar proteinsi

Entry informationi

Entry nameiA0A1Q9N614_9ARCH
AccessioniPrimary (citable) accession number: A0A1Q9N614
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: October 25, 2017
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported