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Protein

Pantothenate synthetase

Gene

panC

Organism
Staphylococcus aureus
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotationSAAS annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC), Pantothenate synthetase (panC)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei38Proton donorUniRule annotation1
Binding sitei62Beta-alanineUniRule annotation1
Binding sitei62PantoateUniRule annotation1
Binding sitei154PantoateUniRule annotation1
Binding sitei177ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi31 – 38ATPUniRule annotation8
Nucleotide bindingi148 – 151ATPUniRule annotation4
Nucleotide bindingi185 – 188ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processPantothenate biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
ORF Names:BSZ10_02490Imported
OrganismiStaphylococcus aureusImported
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000186958 Componenti: Unassembled WGS sequence

Subcellular locationi

A0A1Q8DGM2:
  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd00560. PanC. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC. 1 hit.
InterProiView protein in InterPro
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiView protein in Pfam
PF02569. Pantoate_ligase. 1 hit.
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1Q8DGM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKVIQTVAE MQHITQELKR SGKTIGFVPT MGALHEGHLS MMRRSVEDND
60 70 80 90 100
VTVISVFVNP LQFGPNEDFD AYPRQIDQDV ALVEAIHVDY VFHPTVEEMY
110 120 130 140 150
PDELSVTLKV GRLAEVLEGA QRPGHFDGVV TVVNKLFNIV SPNKAYFGKK
160 170 180 190 200
DAQQLAIVEK MVEDFNHPIE IVGVDIVREA DGLARSSRNV YLTDDERQEA
210 220 230 240 250
VHLSKSLALA QTLYNQGERR SHIIVGEIKA YLTEHTRGHI DEVAIYSYPG
260 270 280
LEVATEIQGQ IFISLAVKFS KARLIDNIIL GSES
Length:284
Mass (Da):31,755
Last modified:April 12, 2017 - v1
Checksum:iCA3262D15ED7D750
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MSFF01000004 Genomic DNA. Translation: OLF32665.1.
RefSeqiWP_053030142.1. NZ_MSFF01000004.1.

Similar proteinsi

Entry informationi

Entry nameiA0A1Q8DGM2_STAAU
AccessioniPrimary (citable) accession number: A0A1Q8DGM2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: October 25, 2017
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported