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Protein

Meso-diaminopimelate D-dehydrogenase

Gene

AUO95_02830

Organism
Corynebacterium glutamicum (Brevibacterium saccharolyticum)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L-tetrahydrodipicolinate, to generate the meso compound, D,L-2,6-diaminopimelate.UniRule annotation

Catalytic activityi

Meso-2,6-diaminoheptanedioate + H2O + NADP+ = L-2-amino-6-oxoheptanedioate + NH3 + NADPH.UniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Meso-diaminopimelate D-dehydrogenase (ddh), Meso-diaminopimelate D-dehydrogenase (FM102_11500), Meso-diaminopimelate D-dehydrogenase (ddh), Meso-diaminopimelate D-dehydrogenase (CYL77_13265), Meso-diaminopimelate D-dehydrogenase (AUO95_02830), Meso-diaminopimelate D-dehydrogenase (CS176_2347)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate, the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei144SubstrateUniRule annotation1
Binding sitei169SubstrateUniRule annotation1
Binding sitei195SubstrateUniRule annotation1
Binding sitei244SubstrateUniRule annotation1
Binding sitei270SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 14NADPUniRule annotation4
Nucleotide bindingi35 – 37NADPUniRule annotation3
Nucleotide bindingi65 – 68NADPUniRule annotation4
Nucleotide bindingi88 – 90NADPUniRule annotation3
Nucleotide bindingi117 – 121NADPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processAmino-acid biosynthesis, Diaminopimelate biosynthesisUniRule annotation, Lysine biosynthesisUniRule annotation
LigandNADPUniRule annotation, Nucleotide-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00034; UER00026.

Names & Taxonomyi

Protein namesi
Recommended name:
Meso-diaminopimelate D-dehydrogenaseUniRule annotation (EC:1.4.1.16UniRule annotation)
Short name:
DAPDHUniRule annotation
Short name:
Meso-DAP dehydrogenaseUniRule annotation
Gene namesi
ORF Names:AUO95_02830Imported
OrganismiCorynebacterium glutamicum (Brevibacterium saccharolyticum)Imported
Taxonomic identifieri1718 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000186616 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini118 – 268DAPDH_CInterPro annotationAdd BLAST151

Sequence similaritiesi

Belongs to the diaminopimelate dehydrogenase family.UniRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR032094. DAPDH_C.
IPR010190. Diaminopimelate_DH_Ddh.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF16654. DAPDH_C. 1 hit.
PIRSFiPIRSF025648. DDH. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01921. DAP-DH. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1Q6BR65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNIRVAIVG YGNLGRSVEK LIAKQPDMDL VGIFSRRATL DTKTPVFDVA
60 70 80 90 100
DVDKHADDVD VLFLCMGSAT DIPEQAPKFA QFACTVDTYD NHRDIPRHRQ
110 120 130 140 150
VMNEAATAAG NVALVSTGWD PGMFSINRVY AAAVLAEHQQ HTFWGPGLSQ
160 170 180 190 200
GHSDALRRIP GVQKAVQYTL PSEEALEKAR RGEAGDLTGK QTHKRQCFVV
210 220 230 240 250
ADPADHERIE NDIRTMPDYF VGYEVEVNFI DEATFDSEHT GMPHGGHVIT
260 270 280 290 300
TGDTGGFNHT VEYILKLDRN PDFTASAQIA FGRAAHRMKQ QGQSGAFTVL
310 320
EVAPYLLSPE NLDDLIARDV
Length:320
Mass (Da):35,223
Last modified:April 12, 2017 - v1
Checksum:i738D2F7B09D68918
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LOQV01000009 Genomic DNA. Translation: OKX84908.1.
RefSeqiWP_074506102.1. NZ_LOQV01000009.1.

Similar proteinsi

Entry informationi

Entry nameiA0A1Q6BR65_CORGT
AccessioniPrimary (citable) accession number: A0A1Q6BR65
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: January 31, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported