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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Mucilaginibacter sp. 44-25
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
ORF Names:BGO48_02950Imported
OrganismiMucilaginibacter sp. 44-25Imported
Taxonomic identifieri1895794 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesSphingobacteriiaSphingobacterialesSphingobacteriaceaeMucilaginibacter

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei706N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd00613. GDC-P. 2 hits.
Gene3Di3.40.640.10. 2 hits.
3.90.1150.10. 1 hit.
HAMAPiMF_00711. GcvP. 1 hit.
InterProiView protein in InterPro
IPR003437. GcvP.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015422. PyrdxlP-dep_Trfase_dom1.
IPR015421. PyrdxlP-dep_Trfase_major.
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiView protein in Pfam
PF02347. GDC-P. 2 hits.
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1Q3U9X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLNINYQEK FQERHIAPNQ ADTEKMLKTI GVHSLDELID QTVPAQIRLK
60 70 80 90 100
NPLNLPAAKS EFDYLNTLKQ TASKNKVFKS YIGQGYYDVI VPGVIQRNIL
110 120 130 140 150
ENPGWYTQYT PYQAEIAQGR LQALLNYQTM IIDLTGMEIA NASLLDEGTA
160 170 180 190 200
AAEAMFMQYS LRKNTKANVF FVSEELFPQT IDILKTRSEP FGIKLQIGDH
210 220 230 240 250
RNVELTEDMF GAIVQYPAGN GEVYNYKDFA SALHEKNIKL TVVADLMSLV
260 270 280 290 300
LLTPPGEWGA DIVVGSSQRF GVPMGFGGPH AAFFATKEEY KRSIPGRIIG
310 320 330 340 350
VTIDSAGNYA LRMALQTREQ HIRRDKATSN ICTAQALLAI MAGMYAVYHG
360 370 380 390 400
PQGLKLIAER IHGLSVLLAK SLADLGYEQQ NKAYFDTLKF DLGELIGPVH
410 420 430 440 450
SEALNNEVNL HYNGSVVTIS LDETTSLKDI ETIVRFFAKV KGKTLNDANF
460 470 480 490 500
DTHKENVEGV IPSELQRTSD FLTHALFNTH HSEHEMLRYI KSLEAKDLSL
510 520 530 540 550
CHSMIALGSC TMKLNATTEM IPVTWAEFSK MHPFAPTDQV GGYMQMFDEL
560 570 580 590 600
NKWLSEITGF ASMSLQPNAG AQGEYAGLMV IRAYHMDRGD GQRNVALIPA
610 620 630 640 650
SAHGTNPASA AMAGMKIVVV KCDDNGNIDV ADLKAKAEQY SNDLSCLMVT
660 670 680 690 700
YPSTHGVFEE SIIEICETIH QHGGQVYMDG ANMNAQVGLT SPANIGADVC
710 720 730 740 750
HLNLHKTFCI PHGGGGPGMG PIGVAKHLVP YLPGHAVVDI DNGKAIHAVS
760 770 780 790 800
AAPWGSASIL LISHAYIAMM GGEGLTNATR YAILNANYIK SRLEHHYPVL
810 820 830 840 850
YTGTNGRCAH EMILDCRSFK PFGIEVTDIA KRLMDYGFHA PTVSFPVAGT
860 870 880 890 900
VMVEPTESEP KHELDRFCDA MISIRHEIDD VEKGLSDKTD NPLKNAPHTA
910 920 930 940 950
AVITGNEWEH PYTRQKAAYP LPYVAQFKFW PSVGRVNDTY GDRTLICSCP
960
PLTDYEFEES EVTTPEYGT
Length:969
Mass (Da):106,924
Last modified:April 12, 2017 - v1
Checksum:i7E7E16D144112C33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MKTS01000015 Genomic DNA. Translation: OJW12904.1.

Similar proteinsi

Entry informationi

Entry nameiA0A1Q3U9X8_9SPHI
AccessioniPrimary (citable) accession number: A0A1Q3U9X8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: February 28, 2018
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported