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Protein

Malate dehydrogenase

Gene

mdh

Organism
Burkholderiales bacterium 64-34
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei95SubstrateUniRule annotation1
Binding sitei101SubstrateUniRule annotation1
Binding sitei108NADUniRule annotation1
Binding sitei115NADUniRule annotation1
Binding sitei134SubstrateUniRule annotation1
Binding sitei165SubstrateUniRule annotation1
Active sitei190Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 18NADUniRule annotation7
Nucleotide bindingi132 – 134NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processTricarboxylic acid cycleUniRule annotation
LigandNADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotationSAAS annotation (EC:1.1.1.37UniRule annotationSAAS annotation)
Gene namesi
Name:mdhUniRule annotation
ORF Names:BGO35_21890Imported
OrganismiBurkholderiales bacterium 64-34Imported
Taxonomic identifieri1895726 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderiales

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 155Ldh_1_NInterPro annotationAdd BLAST150
Domaini160 – 323Ldh_1_CInterPro annotationAdd BLAST164

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_01517 Malate_dehydrog_2, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR010945 Malate_DH_type2
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23382 PTHR23382, 1 hit
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01759 MalateDH-SF1, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1Q3RNG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKPVRVAV TGAAGQIGYA LLFRIASGEM LGKDQPVILQ LLEVPVEGPQ
60 70 80 90 100
KALKGVMMEL DDCAFPLLVG MEAHSDPMTA FKDADYALLV GSRPRGPGME
110 120 130 140 150
RAELLAVNGA IFTAQGKALN AVASRNVKVL VVGNPANTNA YIAMKSAPDL
160 170 180 190 200
PRKNFTAMLR LDHNRAASQI AAKTGKAVAD IEKLTVWGNH SPTMYADYRF
210 220 230 240 250
ATINGESVAQ MINDQEWNAN TFLPTVGKRG AAIIEARGLS SAASAANAAI
260 270 280 290 300
DHMRDWALGT NGKWVTMGIP SDGQYGIPKD TMFGFPVTCE NGEYKIVEGL
310 320
EIDAFSQERI NITLAELQGE QDGVKHLL
Length:328
Mass (Da):35,143
Last modified:April 12, 2017 - v1
Checksum:iD80A5BA97579FB2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MKTF01000065 Genomic DNA Translation: OJV65598.1

Similar proteinsi

Entry informationi

Entry nameiA0A1Q3RNG0_9BURK
AccessioniPrimary (citable) accession number: A0A1Q3RNG0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: April 25, 2018
This is version 9 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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