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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Corynebacterium glutamicum (Brevibacterium saccharolyticum)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei733ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotationImported
ORF Names:CS176_2720Imported
OrganismiCorynebacterium glutamicum (Brevibacterium saccharolyticum)Imported
Taxonomic identifieri1718 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000188825 Componenti: Unassembled WGS sequence

Subcellular locationi

A0A1Q3DUB5:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 176tRNA-synt_1gInterPro annotationAdd BLAST105
Domaini301 – 485tRNA-synt_1_2InterPro annotationAdd BLAST185
Domaini810 – 921Anticodon_1InterPro annotationAdd BLAST112

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi730 – 734"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
PANTHERiPTHR43740. PTHR43740. 1 hit.
PfamiView protein in Pfam
PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1Q3DUB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLLHCLTMT NPSEGTTPLA FRYTPELANK IEGEWQNYWT DNGTFNAPNP
60 70 80 90 100
VGDLAPADGK ALPEDKLFVQ DMFPYPSGAG LHVGHPLGYI ATDVFARYNR
110 120 130 140 150
MLGKNVLHTL GYDAFGLPAE QYAIQTGTHP RTTTMANIEN MKRQLGALGL
160 170 180 190 200
GHDSRRAVAT TDPEFYKWTQ WIFLQIFNSW FDAEQQKARP ISELIPLLES
210 220 230 240 250
GELKTKDGAD YNALGDVEKQ KAVDDYRLVY RSNSTVNWCP GLGTVLANEE
260 270 280 290 300
VTADGRSERG NFPVFRKNLS QWMMRITAYS DRLIDDLELL DWTEKVKSMQ
310 320 330 340 350
RNWIGRSRGA EVDFSAEGET VTVFTTRPDT LFGATYMVLA PEHELVDVLL
360 370 380 390 400
EKAGSYEGVD ARWTNGQASP AEAVAAYRAS IAAKSDLERQ ENKEKTGVFL
410 420 430 440 450
GVYATNPVNG DQIPVFIADY VLTGYGTGAI MAVPAHDERD YEFATVLGLP
460 470 480 490 500
IKEVVAGGNI AEAAFTESGE AVNSANDNGL DINGLAKDEA VAKTIEWLEE
510 520 530 540 550
KELGRGTIQY KLRDWLFARQ RYWGEPFPIV YDENGQAHAL PDSMLPVELP
560 570 580 590 600
EVEDYKPVSF DPEDADSEPS PPLAKAREWV EVELDLGDGK KKYTRDTNVM
610 620 630 640 650
PQWAGSSWYQ LRYVDPSNDE QFCNIENERY WTGPRPETHG PNDPGGVDLY
660 670 680 690 700
VGGVEHAVLH LLYARFWHKV LFDLGHVSSK EPYRRLYNQG YIQAFAYTDS
710 720 730 740 750
RGVYVPADDV EEKDGKFFYQ GEEVNQEYGK MGKSLKNAVA PDDICNNFGA
760 770 780 790 800
DTLRVYEMAM GPLDTSRPWA TKDVVGAQRF LQRLWRLVVD ENTGEVLTRD
810 820 830 840 850
EVLTDDDNKQ LHRTIAGVRD DYTNLRVNTV VAKLIEYVNY LTKTYPDTIP
860 870 880 890 900
AGAVLPLIVM VSPVAPHIAE ELWKKLGHDD TVTYESFPTF EEKWLTDDEI
910 920 930 940 950
ELPVQVNGKV RGRITVAADA SQEQVIEAAL ADEKVQEQIS GKNLIKQIVV
960
PGRMVNLVVK
Length:960
Mass (Da):107,654
Last modified:April 12, 2017 - v1
Checksum:i6DBFE38716975BDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BAYH01000042 Genomic DNA. Translation: GAV98490.1.

Similar proteinsi

Entry informationi

Entry nameiA0A1Q3DUB5_CORGT
AccessioniPrimary (citable) accession number: A0A1Q3DUB5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: October 25, 2017
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported