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Protein

Vitamin B12-dependent ribonucleotide reductase

Gene

SAMN05421689_1187

Organism
Leptospira interrogans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.UniRule annotation

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.UniRule annotation

Cofactori

adenosylcob(III)alaminUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processDNA synthesisUniRule annotation
LigandCobalaminUniRule annotation, Cobalt, Nucleotide-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin B12-dependent ribonucleotide reductaseUniRule annotation (EC:1.17.4.1UniRule annotation)
Gene namesi
ORF Names:SAMN05421689_1187Imported
OrganismiLeptospira interrogansImported
Taxonomic identifieri173 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesLeptospiralesLeptospiraceaeLeptospira
Proteomesi
  • UP000186008 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 147Ribonuc_red_2_NInterPro annotationAdd BLAST117
Domaini198 – 756RIBORED_LARGEInterPro annotationAdd BLAST559
Domaini817 – 921RIBORED_LARGEInterPro annotationAdd BLAST105

Sequence similaritiesi

Belongs to the ribonucleoside diphosphate reductase class-2 family.UniRule annotation

Family and domain databases

CDDicd02888. RNR_II_dimer. 1 hit.
InterProiView protein in InterPro
IPR013678. RNR_2_N.
IPR000788. RNR_lg_C.
IPR013344. RNR_NrdJ/NrdZ.
IPR029072. YebC-like.
PfamiView protein in Pfam
PF08471. Ribonuc_red_2_N. 1 hit.
PF02867. Ribonuc_red_lgC. 2 hits.
PRINTSiPR01183. RIBORDTASEM1.
SUPFAMiSSF75625. SSF75625. 1 hit.
TIGRFAMsiTIGR02504. NrdJ_Z. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1N6UHS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMNRHFTVP QNGESSTIQW TKRNSKITNP DGSKVFEAND ILVPEDWSQV
60 70 80 90 100
AVDILAQKYF RRKGVPKYLK KVQEDGIPEW LQKSIPDTEK LESLKPEDRF
110 120 130 140 150
GGETSALEVF HRLAGCWTYW GYKYKYFSDE ESAKIFYDEI VYMLATQMAA
160 170 180 190 200
PNSPQWFNTG LNWAYGIDGK SQGHYYVDPS TGKLVKSTSA YEHPQPHACF
210 220 230 240 250
IQSVDDDLVN EGGIMDLWVR EARLFKYGSG TGTNFSNLRG ENEPLSGGGK
260 270 280 290 300
SSGLMSFLKI GDRAAGAIKS GGTTRRAAKM VCLDVDHPDI ENFIDWKVTE
310 320 330 340 350
EKKVASLVTG SMLNNRHLNA IMSACYEMEG EDRFNPKKNS SLKKTIQDAK
360 370 380 390 400
KVLIPDNYIK RVIDLARQGY KEILFEELTT DWQSDAYNTV SGQNSNNSIR
410 420 430 440 450
LTNEFMAAVE QDQPWNLYFR TEKEKAKVEG RKAKPSQTLR ARELWEKISY
460 470 480 490 500
AAWASADPGT QYHTTINEWH TCPEDGPINA SNPCSEYMFL DNTACNLASA
510 520 530 540 550
NLQKFVNLET LNFDVEGFRY LCKLWTIILE ISVTMAQFPS KEIAELSYKF
560 570 580 590 600
RTLGLGYANL GSVLMVLGIP YDSQQAMAIT GAISSIMHMT AYATSAEMAK
610 620 630 640 650
EQGPFVGYAK NQKHMLRVIR NHRRAAYNAP SGDYEGLTIT PIGINPAFCP
660 670 680 690 700
SYMLKAAQED ADLALSLGEK YGFRNAQVTV IAPTGTIGLV MDCDTTGIEP
710 720 730 740 750
DFALVKFKKL AGGGYFKIIN QSVPYGLKKL GYSPSEIEAI VNYCKGHATL
760 770 780 790 800
NGAPVINTQA LKEKGFTNEI LEKVEASLPL AFDINFAFNK FNLGENFLTK
810 820 830 840 850
NLGISKEIFD SPGFSLLEHL GFTKEDINKA NDYVCGTMTI ENAPFLKEKD
860 870 880 890 900
YPVFDCANKC GKYGKRFLSY ESHIRIMAAA QPFISGAISK TINLPEEAVI
910 920 930 940 950
EDIKNAYFLS WKMMIKANAL YRDGSKLSQP LNSVLELLNG IEIDDQEEIR
960 970 980 990 1000
EATISKDPVQ IAEKIVTKYI SHRRKLPSRR AGYTQKAIVG GHKVYLRTGE
1010 1020 1030 1040 1050
YEDGQIGEIF IDMHKEGAAF RSLMNAFAIS VSLGLQHGVP LEEYVDAFTF
1060 1070 1080 1090 1100
FKFEPNGIVS GNKHIKMSTS VIDYIFRELA ITYLGRYDLG QVAPEDLRGD
1110 1120 1130 1140 1150
EIGSKRATAE SNGQEKETLS SMTAVIEPTP KKEVETISYS QMISKEKPSS
1160 1170 1180 1190 1200
SPSGISLLEE VKLAKIKGYT GDSCSECGSF EMVRNGSCLK CMSCGSTTGC

S
Length:1,201
Mass (Da):133,918
Last modified:March 15, 2017 - v1
Checksum:i062F88B39A9A120C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FTNA01000018 Genomic DNA. Translation: SIQ65133.1.
RefSeqiWP_000783496.1. NZ_LJBP01000073.1.

Similar proteinsi

Entry informationi

Entry nameiA0A1N6UHS4_LEPIR
AccessioniPrimary (citable) accession number: A0A1N6UHS4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 15, 2017
Last sequence update: March 15, 2017
Last modified: September 27, 2017
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported