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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Propionibacterium sp. CG1_02_60_36
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi97 – 104ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, TranslocationUniRule annotation, Transport
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
ORF Names:AUJ79_03335Imported
OrganismiPropionibacterium sp. CG1_02_60_36Imported
Taxonomic identifieri1805326 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesPropionibacteriaceaePropionibacterium
Proteomesi
  • UP000181908 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation
  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, CytoplasmUniRule annotation, Membrane

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 611SECA_MOTOR_DEADInterPro annotationAdd BLAST611

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili716 – 736Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

HAMAPiMF_01382. SecA. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
IPR036266. SecA_Wing/Scaffold_sf.
IPR036670. SecA_X-link_sf.
PfamiView protein in Pfam
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
PRINTSiPR00906. SECA.
SMARTiView protein in SMART
SM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiView protein in PROSITE
PS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1J4XEC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRVLHAGEG KIIRRLNRIV GQVNSIEEDY VAMDDDELAG QTADFRQRLD
60 70 80 90 100
NGESLDRLLP EAFATVREAS KRVLGKRHFD VQIMGGAALH QCNIAEMKTG
110 120 130 140 150
EGKTLVGLLP AYLEGLLGEG VHIVTVNDYL ARVQSEQMGR VHRFLGLSIS
160 170 180 190 200
AILSDMPPMA RKEAYKADVT YGTNNEFGFD YLRDNMASSL SECVQRGHHY
210 220 230 240 250
AIVDEVDSIL VDEARTPLII SGPAEENKQW YPEFAKIVSR LERDVDYEVD
260 270 280 290 300
EKKRTVSVLG HGITVVEERL GIENLYESAN TPLIGYLNNA IKAKELFHRD
310 320 330 340 350
KDYVVVGGEV LIVDEHTGRT LAGRRYNEGL HQALEAKEHV EIKDEYQTLA
360 370 380 390 400
TITLQNYFRM YDKLAGMTGT AKTEESEFQK IYGLGVIPIP TNRPMIRKDQ
410 420 430 440 450
KDLIYRTEDA KFDAIIADVV ERHEAGQPIL IGTASVAKSE LLSEKLKRAG
460 470 480 490 500
VPHKVLNAKH HESEAAIVAL AGRKGAVTVS TNMAGRGTDI ILGGNPEFLT
510 520 530 540 550
ELDLREKGLD PLEDQDAYQT AWNNTLAKYE EQSQAEHNEV EGLGGLYVIG
560 570 580 590 600
SERHESRRID NQLRGRSGRQ GDPGESRFYL SLQDELMRLF KPEVIDRAMV
610 620 630 640 650
TLKMPEDMPI ESKWVSRQIE SAQKQVEAQN FEMRKNVLKY DDVMNRQRHV
660 670 680 690 700
IYGDRRKVLE GADVEAELRA TTDRVVEAGV RKYAEGYSED WDLDAMWNEI
710 720 730 740 750
GTVYPVGLDL DEYADCQDVE ELIEDFKADA QEAYDRRESE LGEATMRQLE
760 770 780 790 800
REVLLTVLDR KWREHLYEMD YLREGIGLRA MAQRDPLVEY QREGGDMFNS
810 820 830 840 850
MMDSFKEEVV GFLFNLEIET GPQVGLVTDD GGNPVTADSV LPKGNRPRRA
860 870 880 890
LTYSAPDEQG EAETTSEGGQ KPRGEGNRAA RRSAASKKPK NRRNKKRR
Length:898
Mass (Da):101,362
Last modified:February 15, 2017 - v1
Checksum:i539DFA7B3160BD1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MNWQ01000019 Genomic DNA. Translation: OIO57278.1.

Similar proteinsi

Entry informationi

Entry nameiA0A1J4XEC0_9ACTN
AccessioniPrimary (citable) accession number: A0A1J4XEC0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 15, 2017
Last sequence update: February 15, 2017
Last modified: March 28, 2018
This is version 9 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported