ftsZ

Functionⁱ

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	185	GTPUniRule annotation	1
Binding siteⁱ	189	GTPUniRule annotation	1
Binding siteⁱ	232	GTPUniRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	66 – 70	GTPUniRule annotation		5
Nucleotide bindingⁱ	154 – 156	GTPUniRule annotation		3

GO - Molecular functionⁱ

GTPase activity Source: UniProtKB-UniRule
GTP binding Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell septum assembly Source: UniProtKB-UniRule
FtsZ-dependent cytokinesis Source: UniProtKB-UniRule
protein polymerization Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Cell division, SeptationUniRule annotation
Ligand	GTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cell division protein FtsZUniRule annotation
Gene namesⁱ	Name:ftsZUniRule annotation ORF Names:SAMN05216559_2394Imported
Organismⁱ	Halomicrobium zhouiiImported
Taxonomic identifierⁱ	767519 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Haloarculaceae › Halomicrobium
Proteomesⁱ	UP000199062 Componentⁱ: Unassembled WGS sequence

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Automatic assertion according to rulesⁱ
- HAMAP-Rule:MF_00909

Note:

Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componentⁱ

cell division site Source: UniProtKB-UniRule
cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

CytoplasmUniRule annotation

Interactionⁱ

Subunit structureⁱ

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	58 – 250	TubulinInterPro annotationAdd BLAST		193
Domainⁱ	252 – 369	Tubulin_CInterPro annotationAdd BLAST		118

Sequence similaritiesⁱ

Belongs to the FtsZ family.UniRule annotation

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02201. FtsZ_type1. 1 hit.
Gene3Dⁱ	3.30.1330.20. 1 hit. 3.40.50.1440. 1 hit.
HAMAPⁱ	MF_00909. FtsZ. 1 hit.
InterProⁱ	View protein in InterPro IPR000158. Cell_div_FtsZ. IPR020805. Cell_div_FtsZ_CS. IPR018247. EF_Hand_1_Ca_BS. IPR024757. FtsZ_C. IPR008280. Tub_FtsZ_C. IPR018316. Tubulin/FtsZ_2-layer-sand-dom. IPR037103. Tubulin/FtsZ_C_sf. IPR036525. Tubulin/FtsZ_GTPase_sf. IPR003008. Tubulin_FtsZ_GTPase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12327. FtsZ_C. 1 hit. PF00091. Tubulin. 1 hit.
PRINTSⁱ	PR00423. CELLDVISFTSZ.
SMARTⁱ	View protein in SMART SM00864. Tubulin. 1 hit. SM00865. Tubulin_C. 1 hit.
SUPFAMⁱ	SSF52490. SSF52490. 1 hit. SSF55307. SSF55307. 1 hit.
TIGRFAMsⁱ	TIGR00065. ftsZ. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00018. EF_HAND_1. 1 hit. PS01134. FTSZ_1. 1 hit. PS01135. FTSZ_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A1I6LB46-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDSIIDDAIE EAEDEREEPT SGGDRDAANT PETTDDMNTS GTMTDDELSS 
        60         70         80         90        100
VVKDLETKIT VVGCGGAGGN TVTRMMEEGI HGAKLVAANT DAQHLADEVM 
       110        120        130        140        150
ADTKILIGRK RTGGRGAGSV PKIGEEAAQE NIEDIQQSIS GSDMVFVTAG 
       160        170        180        190        200
LGGGTGTGSA PVVAQAAQEA GALTISIVTI PFTAEGERRR ANADAGLERL 
       210        220        230        240        250
RSVSDTVIVV PNDRLLDYAP SMPLQDAFKI CDRVLMRSVK GMTELITKPG 
       260        270        280        290        300
LVNVDFADVR TIMENGGVAM IGLGESDSEN KAQDSIRSAL RSPLLDVEFD 
       310        320        330        340        350
GANSALVNVV GGPDMSIEEA EGVVEEIYDR IDPDARIIWG ASVNDDFEGK 
       360        370        380 
METMIVVTGV ESPQIYGKSE AEREKAAKQV GEDIDYVE

Length:388

Mass (Da):41,002

Last modified:November 22, 2017 - v1

Checksum:ⁱBCA0E95977C61FED

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	FOZK01000002 Genomic DNA. Translation: SFS00696.1.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

FOZK01000002 Genomic DNA. Translation: SFS00696.1.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A0A1I6LB46	F7PMC8 M0CW20 C7P125 UPI000367F8AE V5TK96 Q5R1N6 A0A0B5GZ97 M0LAJ0 M0JRR2 G0HQH0 +15	Halorhabdus tiamatea SARL4B Halosimplex carlsbadense 2-9-1 Halomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541) (Haloarcula mukohataei) Halomicrobium katesii Haloarcula hispanica N601 Haloarcula japonica Haloarcula sp. CBA1115 Haloarcula japonica DSM 6131 Haloarcula californiae ATCC 33799 Haloarcula hispanica (strain ATCC 33960 / DSM 4426 / JCM 8911 / NBRC 102182 / NCIMB 2187 / VKM B-1755) And more	386	UniRef90_F7PMC8	Cluster: Cell division protein FtsZ	26

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A0A1I6LB46	Q48327 L9UND3 M0GRZ9 A0A1H7GS78 M0HU21 M0IJK7 UPI000737D701 A0A0W1RGB9 A0A0D6JSA1 A0A0K1IQY0 +394	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) Haloferax larsenii JCM 13917 Haloferax larsenii Haloferax elongans ATCC BAA-1513 Haloferax sulfurifontis ATCC BAA-897 Haloferax sp. Q22 Haloferax sp. SB3 Haloferax massiliensis Haloferax gibbonsii Haloferax gibbonsii (strain ATCC 33959 / DSM 4427 / JCM 8863 / NBRC 102184 / NCIMB 2188 / Ma 2.38) And more	379	UniRef50_Q48327	Cluster: Cell division protein FtsZ 1	405

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	FOZK01000002 Genomic DNA. Translation: SFS00696.1.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

FOZK01000002 Genomic DNA. Translation: SFS00696.1.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02201. FtsZ_type1. 1 hit.
Gene3Dⁱ	3.30.1330.20. 1 hit. 3.40.50.1440. 1 hit.
HAMAPⁱ	MF_00909. FtsZ. 1 hit.
InterProⁱ	View protein in InterPro IPR000158. Cell_div_FtsZ. IPR020805. Cell_div_FtsZ_CS. IPR018247. EF_Hand_1_Ca_BS. IPR024757. FtsZ_C. IPR008280. Tub_FtsZ_C. IPR018316. Tubulin/FtsZ_2-layer-sand-dom. IPR037103. Tubulin/FtsZ_C_sf. IPR036525. Tubulin/FtsZ_GTPase_sf. IPR003008. Tubulin_FtsZ_GTPase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12327. FtsZ_C. 1 hit. PF00091. Tubulin. 1 hit.
PRINTSⁱ	PR00423. CELLDVISFTSZ.
SMARTⁱ	View protein in SMART SM00864. Tubulin. 1 hit. SM00865. Tubulin_C. 1 hit.
SUPFAMⁱ	SSF52490. SSF52490. 1 hit. SSF55307. SSF55307. 1 hit.
TIGRFAMsⁱ	TIGR00065. ftsZ. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00018. EF_HAND_1. 1 hit. PS01134. FTSZ_1. 1 hit. PS01135. FTSZ_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A1I6LB46_9EURY
Accessionⁱ	A0A1I6LB46Primary (citable) accession number: A0A1I6LB46
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	November 22, 2017
	Last sequence update:	November 22, 2017
	Last modified:	March 28, 2018
	This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB - A0A1I6LB46 (A0A1I6LB46_9EURY)

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Cell division protein FtsZ

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Functionⁱ

Sites

Regions

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Interactionⁱ

Subunit structureⁱ

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Family and domain databases

Sequenceⁱ

Sequence databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A0A1I6LB46 (A0A1I6LB46_9EURY)

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Cell division protein FtsZ

ftsZ

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ