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Protein

L-lactate dehydrogenase

Gene

lldD

Organism
Stenotrophomonas maltophilia (Pseudomonas maltophilia) (Xanthomonas maltophilia)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.UniRule annotationSAAS annotation

Catalytic activityi

(S)-lactate + an oxidized electron acceptor = pyruvate + a reduced electron acceptor.UniRule annotationSAAS annotation

Cofactori

FMNUniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei24SubstrateUniRule annotation1
Binding sitei106FMNUniRule annotation1
Binding sitei127FMNUniRule annotation1
Binding sitei129SubstrateUniRule annotation1
Binding sitei155FMNUniRule annotation1
Binding sitei164SubstrateUniRule annotation1
Binding sitei251FMNUniRule annotation1
Active sitei275Proton acceptorUniRule annotation1
Binding sitei278SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi306 – 330FMNUniRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
LigandFlavoprotein, FMNUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotationSAAS annotation (EC:1.1.-.-UniRule annotationSAAS annotation)
Gene namesi
Name:lldDUniRule annotation
ORF Names:SAMN04487782_0442Imported
OrganismiStenotrophomonas maltophilia (Pseudomonas maltophilia) (Xanthomonas maltophilia)Imported
Taxonomic identifieri40324 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeStenotrophomonasStenotrophomonas maltophilia group
Proteomesi
  • UP000183628 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cell inner membrane SAAS annotation; Peripheral membrane protein SAAS annotation
  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membraneSAAS annotation, Cell membrane, Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 379FMN hydroxy acid dehydrogenaseInterPro annotationAdd BLAST379

Sequence similaritiesi

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd02809 alpha_hydroxyacid_oxid_FMN, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01559 L_lact_dehydr, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR012133 Alpha-hydoxy_acid_DH_FMN
IPR000262 FMN-dep_DH
IPR037396 FMN_HAD
IPR008259 FMN_hydac_DH_AS
IPR020920 LldD
PfamiView protein in Pfam
PF01070 FMN_dh, 1 hit
PIRSFiPIRSF000138 Al-hdrx_acd_dh, 1 hit
PROSITEiView protein in PROSITE
PS00557 FMN_HYDROXY_ACID_DH_1, 1 hit
PS51349 FMN_HYDROXY_ACID_DH_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1I6JKB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIISASTDYR AAAKRRLPPF LFHYIDGGAY AEHTLKRNVS DLSDIALRQR
60 70 80 90 100
VLRNMSDLSL ETELFGETLA MPVALAPVGL TGMYARRGEV QAARAADSRG
110 120 130 140 150
IPFTLSTVSV CPIEEVAPAI QRSMWFQLYV LRDRGFMRNA LERAQAAGVT
160 170 180 190 200
TLVFTVDMPV PGARYRDAHS GMSGPNAPLR RIGQAITHPR WAWDVGLFGR
210 220 230 240 250
PHDLGNISTY RGNPTGLEDY IGWLGSNFDP SISWKDLEWI REFWKGPMVI
260 270 280 290 300
KGILDPEDAR DAVAFGADGI VVSNHGGRQL DGVLSTARAL PAIADAVQGD
310 320 330 340 350
LKILADSGIR TGLDVVRMLA LGADTVLLGR AFVYALAAQG EAGVANLLDL
360 370
IAREMRVAMT LTGAHRIADI GRDSLVRLP
Length:379
Mass (Da):41,202
Last modified:April 12, 2017 - v1
Checksum:iC01170442FBAEC8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FOZF01000001 Genomic DNA Translation: SFR79405.1
RefSeqiWP_074899161.1, NZ_FOZF01000001.1

Similar proteinsi

Entry informationi

Entry nameiA0A1I6JKB3_STEMA
AccessioniPrimary (citable) accession number: A0A1I6JKB3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: March 28, 2018
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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