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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Streptacidiphilus jiangxiensis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi100 – 107ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, TranslocationUniRule annotation, Transport
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
ORF Names:SAMN05414137_110259Imported
OrganismiStreptacidiphilus jiangxiensisImported
Taxonomic identifieri235985 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptacidiphilus
Proteomesi
  • UP000183015 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation
  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, CytoplasmUniRule annotation, Membrane

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 614SECA_MOTOR_DEADInterPro annotationAdd BLAST614

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili529 – 549Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

HAMAPiMF_01382. SecA. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
IPR036266. SecA_Wing/Scaffold_sf.
IPR036670. SecA_X-link_sf.
PfamiView protein in Pfam
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
PRINTSiPR00906. SECA.
SMARTiView protein in SMART
SM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiView protein in PROSITE
PS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1H7RQ87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVFDKILRA GEGKILRKLS KIADQVNSIE EDFVNLTDAE LRALTDEFRE
60 70 80 90 100
RLADGETLDD ILPEAFATVR EAAKRTLGQR HYDVQIMGGA ALHLGYVAEM
110 120 130 140 150
RTGEGKTLVG TLPTYLNALA GKGVHLITTN DYLAERDSEW MGRVHRFLGL
160 170 180 190 200
EVGCILANMS PAERRAQYAC DITYGTNNEF GFDYLRDNMA WSKDELVQRG
210 220 230 240 250
HNFAVVDEVD SILIDEARTP LIISGPADAA TKWYGDFAKM VQRLKIDRDY
260 270 280 290 300
EVDEKKRTVG ILEAGVTRVE DYLGIENLYD VTNTPLVGFL NNAIKAKELY
310 320 330 340 350
KADKDYVVMN GEVMIVDEHT GRILAGRRYN EGMHQAIEAK EGVEVQNENQ
360 370 380 390 400
TLATITLQNF FRLYTKLSGM TGTATTEAAE FHQIYKLGVV PIPTNKTPLR
410 420 430 440 450
IDQPDLIYKS EPAKFAAVVE DIVVRHEKGQ PVLVGTTSVE KSEYLSQELR
460 470 480 490 500
KRGVPHEVLN AKNHEREALV VAQAGRKGSV TVATNMAGRG TDIMLGGNPE
510 520 530 540 550
HLAAAELAQR GLSPVDTPEE YEAAWGSALD KAKEAVKAEQ EEVQDLGGLY
560 570 580 590 600
VLGTERHESR RIDNQLRGRS GRQGDPGESR FYLSLGDDLM RLFKAGMVER
610 620 630 640 650
VLSMANVPED VPIESKMVTR AIASAQTQVE QQNFEIRKNV LKYDEVLNRQ
660 670 680 690 700
REVIYGERRR VLEGEDLHEQ IDHFIDDTVD AYVKDATEDG FAEEWDWEKL
710 720 730 740 750
WQALGQLYPI ALKTEDFEDE NGDRSNATAD SLSEAVKEDV HTRYVEREEQ
760 770 780 790 800
LGETVMRELE RRVVLSVLDR RWREHLYEMD YLQEGIGMRA LAQRDPLVEY
810 820 830 840 850
QREGFDMFGA MMDGIKEESI SYLFNLEVQV EQQVEEVPVA DAVPTPEIRA
860 870 880 890 900
KGLDAPQRPD RLHYKAPTID TADGIVETDI TTDLEDDVED GDGLTRAERR
910
KAAKGGRRRK K
Length:911
Mass (Da):102,669
Last modified:April 12, 2017 - v1
Checksum:i5CCC2182271EF75D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FOAZ01000010 Genomic DNA. Translation: SEL62372.1.
RefSeqiWP_042459816.1. NZ_FOAZ01000010.1.

Similar proteinsi

Entry informationi

Entry nameiA0A1H7RQ87_9ACTN
AccessioniPrimary (citable) accession number: A0A1H7RQ87
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: March 28, 2018
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported