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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Azotobacter beijerinckii
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotationSAAS annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotationSAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL)
  2. Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processPurine biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationSAAS annotation (EC:6.3.3.1UniRule annotationSAAS annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
ORF Names:SAMN04244579_03128Imported
OrganismiAzotobacter beijerinckiiImported
Taxonomic identifieri170623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter
Proteomesi
  • UP000199005 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 164AIRSInterPro annotationAdd BLAST107
Domaini177 – 341AIRS_CInterPro annotationAdd BLAST165

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd02196. PurM. 1 hit.
Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS. 1 hit.
InterProiView protein in InterPro
IPR010918. PurM-like_C_dom.
IPR036676. PurM-like_C_sf.
IPR016188. PurM-like_N.
IPR036921. PurM-like_N_sf.
IPR004733. PurM_cligase.
PANTHERiPTHR10520. PTHR10520. 1 hit.
PfamiView protein in Pfam
PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1H6WCA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKQPSLSYK DAGVDIDAGE ALVERIKGVA RRTARPEVMG GLGGFGALCE
60 70 80 90 100
IPAGYKQPVL VSGTDGVGTK LRLAMNLGKH DSIGIDLVAM CVNDLVVCGA
110 120 130 140 150
EPLFFLDYYA TGKLNVDVAA RVVTGIGEGC EMAGCALVGG ETAEMPGMYE
160 170 180 190 200
GEDYDLAGFC VGVVEKSEII DGSKVAAGDA LIALPSSGPH SNGYSLIRKI
210 220 230 240 250
LEVSGTEVAS ASLDGKPLAD LLMAPTRIYV KPLLKLIKET GAVKAMAHIT
260 270 280 290 300
GGGLTENIPR VLPQGTQAVI DVASWTRPAV FDWLQEKGNV DEREMHRVLN
310 320 330 340 350
CGVGMVICVA PDKVEQALAV LREASEQPWL IGSIAAGEGT ERVLLNNLKA

H
Length:351
Mass (Da):36,800
Last modified:November 22, 2017 - v1
Checksum:i02074D0A3A9CF351
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FNYO01000038 Genomic DNA. Translation: SEJ10182.1.

Similar proteinsi

Entry informationi

Entry nameiA0A1H6WCA2_9GAMM
AccessioniPrimary (citable) accession number: A0A1H6WCA2
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2017
Last sequence update: November 22, 2017
Last modified: March 28, 2018
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported