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Protein

Kynureninase

Gene

kynU

Organism
Frankineae bacterium MT45
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-kynurenine degradation

This protein is involved in step 1 of the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Kynureninase (kynU)
This subpathway is part of the pathway L-kynurenine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine, the pathway L-kynurenine degradation and in Amino-acid degradation.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Kynureninase (kynU)
  3. no protein annotated in this organism
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei115Pyridoxal phosphate; via amide nitrogenUniRule annotation1
Binding sitei116Pyridoxal phosphateUniRule annotation1
Binding sitei210Pyridoxal phosphateUniRule annotation1
Binding sitei213Pyridoxal phosphateUniRule annotation1
Binding sitei235Pyridoxal phosphateUniRule annotation1
Binding sitei265Pyridoxal phosphateUniRule annotation1
Binding sitei291Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processPyridine nucleotide biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:kynUUniRule annotation
ORF Names:SAMN05444157_1138Imported
OrganismiFrankineae bacterium MT45Imported
Taxonomic identifieri1882833 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaFrankialesunclassified Frankiales

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei236N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini174 – 352Aminotran_5InterPro annotationAdd BLAST179

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni143 – 146Pyridoxal phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase. 1 hit.
InterProiView protein in InterPro
IPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiView protein in Pfam
PF00266. Aminotran_5. 1 hit.
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1G8Q192-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIQTRDEAA AADAADPLAA VRAKFALPAG LIYLDGNSLG ALPAATPGAV
60 70 80 90 100
ADAVTRQWGA DLITSWGPTG GSREGQSEQE QVGSQGWWAL PALVGDRIGA
110 120 130 140 150
LIGAAAGQVM CGDSTSVQLF QLMVAAARLR PQRGTLVIDD ANFPTDTYIA
160 170 180 190 200
ESVARLLGLR LLRVAPGDFV PDGDTAVVAY SVVDYRSGEL FDTAAITAAA
210 220 230 240 250
HQAGAVVLWD LCHAAGALEI GLDELGADLA VGCSYKYLNG GPGAPAWAYV
260 270 280 290 300
AERHQSDIDL PITGWHGHRD PFSLAPSFAP APGIERLRIG TPPVLSMQAL
310 320 330 340 350
ASALDVWEGV SLTEVRRKSL AMTDLVIDYA DRELAGFGVE VMTPREHHRR
360 370 380 390 400
GSQVALRIPD ALRVMQELID RGVMGDFRAP DLLRLGFTPL TLSYTDVWDA
410
MAILRQLLQK EGDSPV
Length:416
Mass (Da):44,097
Last modified:January 18, 2017 - v1
Checksum:i5836BE5483BB9B10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT629697 Genomic DNA. Translation: SDI98519.1.

Similar proteinsi

Entry informationi

Entry nameiA0A1G8Q192_9ACTN
AccessioniPrimary (citable) accession number: A0A1G8Q192
Entry historyiIntegrated into UniProtKB/TrEMBL: January 18, 2017
Last sequence update: January 18, 2017
Last modified: September 27, 2017
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation