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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Sideroxydans sp. GWF2_59_14
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotationSAAS annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotationSAAS annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei151May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
ORF Names:A2100_01450Imported
OrganismiSideroxydans sp. GWF2_59_14Imported
Taxonomic identifieri1802154 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesGallionellaceaeSideroxydans

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B. 1 hit.
InterProiView protein in InterPro
IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
PANTHERiPTHR36445. PTHR36445. 1 hit.
PfamiView protein in Pfam
PF02649. GCHY-1. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1G3IKI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSAKPIADV QNSADTRQLA INKVGIKSIR HPIQVKDKSL GVQHTIATFN
60 70 80 90 100
MYVHLPHNFK GTHMSRFVQI LNQHGREISV ESFESILREM VEKLEAKSGY
110 120 130 140 150
IEMSFPYFVN KIAPVSGVQS MLDYDVTFIG EVVDGAYRFT MKVLIPVTSL
160 170 180 190 200
CPCSKEISDR GAHNQRSHVT LTVRTRSSVW IEEVVRFAED HASSELYGLL
210 220 230 240 250
KRPDEKFVTE RAYDNPKFVE DMVRDVAAVL NADDRIEAYT VESENFESIH
260
NHSAYALIER DKTQG
Length:265
Mass (Da):30,081
Last modified:January 18, 2017 - v1
Checksum:i2F5CEBB16D580A45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MIAD01000009 Genomic DNA. Translation: OHC81544.1.

Similar proteinsi

Entry informationi

Entry nameiA0A1G3IKI2_9PROT
AccessioniPrimary (citable) accession number: A0A1G3IKI2
Entry historyiIntegrated into UniProtKB/TrEMBL: January 18, 2017
Last sequence update: January 18, 2017
Last modified: October 25, 2017
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported