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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Deltaproteobacteria bacterium RBG_16_49_23
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei624ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotation, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
ORF Names:A2V86_08465Imported
OrganismiDeltaproteobacteria bacterium RBG_16_49_23Imported
Taxonomic identifieri1797840 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteria

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 175tRNA-synt_1gInterPro annotationAdd BLAST135
Domaini225 – 412tRNA-synt_1_2InterPro annotationAdd BLAST188
Domaini425 – 582tRNA-synt_1InterPro annotationAdd BLAST158
Domaini610 – 661tRNA-synt_1InterPro annotationAdd BLAST52
Domaini704 – 825Anticodon_1InterPro annotationAdd BLAST122

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionUniRule annotationAdd BLAST11
Motifi621 – 625"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1F9C9U1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSKYSPKEI EEKWQRVWEN LKLFKVTEDE NRKKYYLLEM FPYPSGKIHM
60 70 80 90 100
GHVRNYSIGD VVARYKKMKG FNVLHPMAWD AFGMPAENAA IEHGVHPAKW
110 120 130 140 150
TYENIEYMKR QLKRMGISYD WDREFATCDA SYYRWEQLFF LKMYEKGLAY
160 170 180 190 200
KKRSTVNWCE ICKTVLANEQ VMGDGTCWRG HADDPGVTQK DLEQWFFKIT
210 220 230 240 250
DYAEDLLEWC DKLPGWPERV LTMQRNWIGK SIGAEIHFPL EHSKETIKVF
260 270 280 290 300
TTRQDTVFGA TFMSLAPEHP LALTLSKGTA QEKEVKDFVE KMKRQDRMKR
310 320 330 340 350
TSPTTEKEGV FTGGYCLNPV TEARMPIFVA NFVLMEYGTG AVMAVPTHDQ
360 370 380 390 400
RDFEFAKQYG LPLIVVIQQE DQALNANTMT QAYEGEGGLV NSGKFNGMSS
410 420 430 440 450
MKAREEIAKH LEEKGLGGEK ISYRLRDWGI SRQRYWGAPI PIIYCEKCGT
460 470 480 490 500
VPVPERDLPV LLPSDVEVTG MGESPLVSAK EFVEARCPKC GGAGRRETDT
510 520 530 540 550
MDTFVESSWY FDRFACPDYH EGPLDKKRVD YWMPVDQYIG GIEHAILHLL
560 570 580 590 600
YSRFFTRVLK EMGWLSVKEP FTNLLTQGMV CKEVLECPKD GYLFPDEVER
610 620 630 640 650
EGEAFRCRKC GGQVTAGRLE KMSKSKRNVV DPEYLVEKFG ADTARIFCLF
660 670 680 690 700
AAPPEKDLDW SDLGVEGSFR FLNRVWRLFS EQHSRLRDAA SLPFGTSLEG
710 720 730 740 750
DAKLLRQKTH KTIKKVTEDI ERFHFNTAIS AIMELVNEIY TSEVKNREDE
760 770 780 790 800
TSRRLMREAI EAAIILLSPF VPHFAEELWE GLGNKESVIK KDWPDYDPEA
810 820 830 840 850
VSEDEVLIVV QVHGKVRDRI TVPASYGEEE IKTWALKSER IQKLVAGKAI
860
KRVILVPQKL VNIVC
Length:865
Mass (Da):99,625
Last modified:February 15, 2017 - v1
Checksum:i39BE72A635B42B85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MGQQ01000025 Genomic DNA Translation: OGP79255.1

Similar proteinsi

Entry informationi

Entry nameiA0A1F9C9U1_9DELT
AccessioniPrimary (citable) accession number: A0A1F9C9U1
Entry historyiIntegrated into UniProtKB/TrEMBL: February 15, 2017
Last sequence update: February 15, 2017
Last modified: June 20, 2018
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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