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Protein

LexA repressor

Gene

lexA

Organism
Shewanella colwelliana (Alteromonas colwelliana)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.UniRule annotation

Catalytic activityi

Hydrolysis of Ala-|-Gly bond in repressor LexA.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei122For autocatalytic cleavage activityUniRule annotation1
Active sitei159For autocatalytic cleavage activityUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi28 – 48H-T-H motifUniRule annotationAdd BLAST21

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation, RepressorUniRule annotationSAAS annotation
Biological processDNA damage, DNA repairUniRule annotationSAAS annotation, DNA replicationUniRule annotationSAAS annotation, SOS responseUniRule annotationSAAS annotation, Transcription, Transcription regulationUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
LexA repressorUniRule annotationSAAS annotation (EC:3.4.21.88UniRule annotation)
Gene namesi
Name:lexAUniRule annotation
ORF Names:BEL05_17500Imported
OrganismiShewanella colwelliana (Alteromonas colwelliana)Imported
Taxonomic identifieri23 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000095230 Componenti: Unassembled WGS sequence

PTM / Processingi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei87 – 88Cleavage; by autolysisUniRule annotation2

Keywords - PTMi

Autocatalytic cleavageUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 65LexA_DNA_bindInterPro annotationAdd BLAST65
Domaini117 – 183Peptidase_S24InterPro annotationAdd BLAST67

Sequence similaritiesi

Belongs to the peptidase S24 family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_00015. LexA. 1 hit.
InterProiView protein in InterPro
IPR006200. LexA.
IPR006199. LexA_DNA-bd_dom.
IPR006197. Peptidase_S24_LexA.
IPR015927. Peptidase_S24_S26A/B/C.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF01726. LexA_DNA_bind. 1 hit.
PF00717. Peptidase_S24. 1 hit.
PRINTSiPR00726. LEXASERPTASE.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR00498. lexA. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1E5IYN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPLTPRQAE ILDLIKRNIA DTGMPPTRAE IARRLGFKSA NAAEEHLKAL
60 70 80 90 100
AKKGCIEIMP GTSRGIKLTQ EDEPEELGLP LIGQVAAGEP ILAQEHVEQH
110 120 130 140 150
YKVDPSMFRP SADFLLRVRG DSMKDIGILE GDLLAVHKVE QARNGQVVVA
160 170 180 190 200
RVEDDVTVKR FEKKGNTVYL HAENEEYSPI VVDLSTQSLS IEGLAVGVIR

NGDWQ
Length:205
Mass (Da):22,639
Last modified:January 18, 2017 - v1
Checksum:i599F2999F823C866
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MCBT01000004 Genomic DNA. Translation: OEG75616.1.
RefSeqiWP_028763361.1. NZ_MCBT01000004.1.

Genome annotation databases

EnsemblBacteriaiOEG75616; OEG75616; BEL05_17500.

Similar proteinsi

Entry informationi

Entry nameiA0A1E5IYN6_SHECO
AccessioniPrimary (citable) accession number: A0A1E5IYN6
Entry historyiIntegrated into UniProtKB/TrEMBL: January 18, 2017
Last sequence update: January 18, 2017
Last modified: June 7, 2017
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported