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Protein

Ceramide very long chain fatty acid hydroxylase

Gene

CYBJADRAFT_175337

Organism
Cyberlindnera jadinii NRRL Y-1542
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Ceramide hydroxylase involved in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids. Hydroxylates the very long chain fatty acid of ceramides at C2 and C3.UniRule annotation

Cofactori

Fe cationUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
Biological processFatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandHemeSAAS annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ceramide very long chain fatty acid hydroxylaseUniRule annotation (EC:1.-.-.-UniRule annotation)
Gene namesi
ORF Names:CYBJADRAFT_175337Imported
OrganismiCyberlindnera jadinii NRRL Y-1542Imported
Taxonomic identifieri983966 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeCyberlindnera
Proteomesi
  • UP000094389 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei189 – 208HelicalSequence analysisAdd BLAST20
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 85Cytochrome b5 heme-bindingInterPro annotationAdd BLAST82

Sequence similaritiesi

Belongs to the sterol desaturase family. SCS7 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiView protein in InterPro
IPR001199. Cyt_B5-like_heme/steroid-bd.
IPR036400. Cyt_B5-like_heme/steroid_sf.
IPR018506. Cyt_B5_heme-BS.
IPR006694. Fatty_acid_hydroxylase.
IPR014430. Scs7.
PfamiView protein in Pfam
PF00173. Cyt-b5. 1 hit.
PF04116. FA_hydroxylase. 1 hit.
PIRSFiPIRSF005149. IPC-B_HD. 1 hit.
PRINTSiPR00363. CYTOCHROMEB5.
SMARTiView protein in SMART
SM01117. Cyt-b5. 1 hit.
SUPFAMiSSF55856. SSF55856. 1 hit.
PROSITEiView protein in PROSITE
PS00191. CYTOCHROME_B5_1. 1 hit.
PS50255. CYTOCHROME_B5_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1E4RVB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTLPLFAQS DLASHNTEKD CWVSLYHRKI YDVTDFLDEH PGGDELILEW
60 70 80 90 100
GGKDITDILA DESSHLHSEM TYEMLDENYL VGYLATAEEE KELLANPKHS
110 120 130 140 150
QEVKLDEEFD STAMHGTPAY EKLNIVTDFD RDLKNHKFLD LTKPLLLQVL
160 170 180 190 200
FADFSKEFYL DQVHRPRHYG KGSAPLFGNF LEPVSLTPWW VVPTVWLPVD
210 220 230 240 250
LFLLYLGLSN LNLFLGLSLF SIGLFVWTLI EYCLHRFLFH LDYYLPDHPV
260 270 280 290 300
AFTVHFLLHG VHHYLPMDRY RLVMPPTLFV VLCYPFYKLI FSIFPFYMAC
310 320 330 340 350
AGFAGGFLGY ICYDMTHYFL HHARLPAYMQ KLKKYHLEHH YKNYELGFGV
360 370
TSWFWDKIFG TYLPIGETAP QKQN
Length:374
Mass (Da):43,782
Last modified:January 18, 2017 - v1
Checksum:iAAB6618C35DD0028
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KV453943 Genomic DNA. Translation: ODV71202.1.
RefSeqiXP_020068241.1. XM_020216687.1.

Genome annotation databases

EnsemblFungiiODV71202; ODV71202; CYBJADRAFT_175337.
GeneIDi30991083.

Similar proteinsi

Entry informationi

Entry nameiA0A1E4RVB0_CYBJA
AccessioniPrimary (citable) accession number: A0A1E4RVB0
Entry historyiIntegrated into UniProtKB/TrEMBL: January 18, 2017
Last sequence update: January 18, 2017
Last modified: November 22, 2017
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported