panC

Functionⁱ

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotationSAAS annotation

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Catalytic activityⁱ

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotationSAAS annotation

Pathwayⁱ: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:

Pantothenate synthetase (panC)

This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	41	Proton donorUniRule annotation	1
Binding siteⁱ	65	Beta-alanineUniRule annotation	1
Binding siteⁱ	65	PantoateUniRule annotation	1
Binding siteⁱ	157	PantoateUniRule annotation	1
Binding siteⁱ	180	ATP; via amide nitrogen and carbonyl oxygenUniRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	34 – 41	ATPUniRule annotation	8
Nucleotide bindingⁱ	151 – 154	ATPUniRule annotation	4
Nucleotide bindingⁱ	188 – 191	ATPUniRule annotation	4

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
pantoate-beta-alanine ligase activity Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

pantothenate biosynthetic process Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	LigaseUniRule annotationSAAS annotationImported
Biological process	Pantothenate biosynthesisUniRule annotationSAAS annotation
Ligand	ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayⁱ	UPA00028; UER00005.

UniPathwayⁱ

UPA00028; UER00005.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation) Short name: PSUniRule annotation Alternative name(s): Pantoate--beta-alanine ligaseUniRule annotation Pantoate-activating enzymeUniRule annotation
Gene namesⁱ	Name:panCUniRule annotation ORF Names:AUC68_09780Imported
Organismⁱ	Methyloceanibacter methanicusImported
Taxonomic identifierⁱ	1774968 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › unclassified Rhizobiales › Methyloceanibacter
Proteomesⁱ	UP000094501 Componentⁱ: Unassembled WGS sequence

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Automatic assertion according to rulesⁱ
- HAMAP-Rule:MF_00158
SAAS annotation
Automatic assertion according to rulesⁱ
- SAAS:SAAS00387750

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

CytoplasmUniRule annotationSAAS annotation

Interactionⁱ

Subunit structureⁱ

Homodimer.UniRule annotationSAAS annotation

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the pantothenate synthetase family.UniRule annotationSAAS annotation

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00560. PanC. 1 hit.
Gene3Dⁱ	3.40.50.620. 1 hit.
HAMAPⁱ	MF_00158. PanC. 1 hit.
InterProⁱ	View protein in InterPro IPR004821. Cyt_trans-like. IPR003721. Pantoate_ligase. IPR014729. Rossmann-like_a/b/a_fold.
PANTHERⁱ	PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02569. Pantoate_ligase. 1 hit.
TIGRFAMsⁱ	TIGR00125. cyt_tran_rel. 1 hit. TIGR00018. panC. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A1E3VZI4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTTEIETVRT VADLRARVSA WRARGGSLAM VPTMGAIHEG HMSLVRQAKG 
        60         70         80         90        100
LAGHVVASIF VNPLQFGPSE DFEAYPRGEA RDAALLAEAG ADLLFAPGAG 
       110        120        130        140        150
EMYPEGFATT VHVADITEGL CGASRPDHFD GVATVVAKLL LQCGPDVAIF 
       160        170        180        190        200
GEKDYQQLLV IKRLVRDLNI PVKIVGGAIV REPDGLALSS RNAYLSAEER 
       210        220        230        240        250
ETAPLLYATI QQAAHALAAG HATEHALESA RAALEAAGFR VDYLEARDPE 
       260        270        280 
TLARLSGSVA TARILVAAFL GKTRLIDNVP VPPRA

Length:285

Mass (Da):30,179

Last modified:January 18, 2017 - v1

Checksum:ⁱ8D0388A997FF681B

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	LPWG01000013 Genomic DNA. Translation: ODR98671.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_069438129.1. NZ_LPWG01000013.1.

Genome annotation databases

EnsemblBacteriaⁱ	ODR98671; ODR98671; AUC68_09780.

EnsemblBacteriaⁱ

ODR98671; ODR98671; AUC68_09780.

Similar proteinsⁱ

50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A0A1E3VZI4	Q07L39 UPI00034D84AF J3A7X4 A0A0Q8FJ91 A0A198FJS2 A0A1N6VPG3 A0A0T6UNY7 A0A2E0A034 T0HRA8 A0A1E1F405 +1246	Rhodopseudomonas palustris (strain BisA53) Halomonas jeotgali Caulobacter sp. AP07 Caulobacter sp. Root655 Cosenzaea myxofaciens ATCC 19692 Luteimonas tolerans Pseudomonas sp. TTU2014-080ASC Oceanospirillaceae bacterium Sphingobium baderi LL03 Sphingobium cloacae And more	283	UniRef50_Q07L39	Cluster: Pantothenate synthetase	1,257

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	LPWG01000013 Genomic DNA. Translation: ODR98671.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_069438129.1. NZ_LPWG01000013.1.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ODR98671; ODR98671; AUC68_09780.

EnsemblBacteriaⁱ

ODR98671; ODR98671; AUC68_09780.

Enzyme and pathway databases

UniPathwayⁱ	UPA00028; UER00005.

UniPathwayⁱ

UPA00028; UER00005.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00560. PanC. 1 hit.
Gene3Dⁱ	3.40.50.620. 1 hit.
HAMAPⁱ	MF_00158. PanC. 1 hit.
InterProⁱ	View protein in InterPro IPR004821. Cyt_trans-like. IPR003721. Pantoate_ligase. IPR014729. Rossmann-like_a/b/a_fold.
PANTHERⁱ	PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02569. Pantoate_ligase. 1 hit.
TIGRFAMsⁱ	TIGR00125. cyt_tran_rel. 1 hit. TIGR00018. panC. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A1E3VZI4_9RHIZ
Accessionⁱ	A0A1E3VZI4Primary (citable) accession number: A0A1E3VZI4
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	January 18, 2017
	Last sequence update:	January 18, 2017
	Last modified:	October 25, 2017
	This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB - A0A1E3VZI4 (A0A1E3VZI4_9RHIZ)

Your basket is currently empty. ⁱ

Pantothenate synthetase

Select a section on the left to see content.

Functionⁱ

Miscellaneous

Catalytic activityⁱ

Pathwayⁱ: (R)-pantothenate biosynthesis

Sites

Regions

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Interactionⁱ

Subunit structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Enzyme and pathway databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Caution

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A0A1E3VZI4 (A0A1E3VZI4_9RHIZ)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Pantothenate synthetase

panC

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: (R)-pantothenate biosynthesis

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Your basket is currently empty. ⁱ

Functionⁱ

Pathwayⁱ: (R)-pantothenate biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ