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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Staphylococcus aureus
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
Biological processAntibiotic resistanceUniRule annotationSAAS annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotationImported
ORF Names:SAMEA1708914_00394Imported
OrganismiStaphylococcus aureusImported
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei50 – 68HelicalUniRule annotationAdd BLAST19
Transmembranei99 – 118HelicalUniRule annotationAdd BLAST20
Transmembranei130 – 150HelicalUniRule annotationAdd BLAST21
Transmembranei162 – 182HelicalUniRule annotationAdd BLAST21
Transmembranei202 – 223HelicalUniRule annotationAdd BLAST22
Transmembranei235 – 256HelicalUniRule annotationAdd BLAST22
Transmembranei268 – 288HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotationSAAS annotation, Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase. 1 hit.
InterProiView protein in InterPro
IPR003824. UppP.
PANTHERiPTHR30622. PTHR30622. 1 hit.
PfamiView protein in Pfam
PF02673. BacA. 1 hit.
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1D4GUF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIIELIKGI ILGVVEGLTE FAPVSSTGHM ILVDDMWLKS SEFLGSQSAF
60 70 80 90 100
TFKIVIQLGS VFAAAWVFRE RFLEILHIGK HKHVEGDNDQ QRRSKPRRLN
110 120 130 140 150
LLHVLAGMVP AGILGLLFDD FIEEHLFSVP TVMIGLFVGA IYMIIADKYS
160 170 180 190 200
AKVKNPQTVD QISYFQAFVI GISQAVAMWP GFSRSGSTIS TGVLMKLNHK
210 220 230 240 250
AASDFTFIMA VPIMLAASGL SLLKHYQDIQ IADIPFYILG FLAAFTVGLI
260 270 280 290
AIKTFLHLIN KIKLIPFAIY RIVLVIFIAI LYFGFGIGKG I
Length:291
Mass (Da):32,241
Last modified:November 30, 2016 - v1
Checksum:iC6B96EFA16369C7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FMPL01000002 Genomic DNA. Translation: SCS28591.1.
RefSeqiWP_070047446.1. NZ_MKYV01000002.1.

Similar proteinsi

Entry informationi

Entry nameiA0A1D4GUF9_STAAU
AccessioniPrimary (citable) accession number: A0A1D4GUF9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2016
Last sequence update: November 30, 2016
Last modified: September 27, 2017
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)