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Protein

Urease subunit alpha

Gene

ureC

Organism
Shigella sp. FC130
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotationSAAS annotation

Cofactori

Ni cationUniRule annotationNote: Binds 2 nickel ions per subunit.UniRule annotation

Pathwayi: urea degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Urease subunit beta (ureB), Urease subunit alpha (ureC), Urease subunit gamma (ureA)
This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi134Nickel 1; via tele nitrogenUniRule annotation1
Metal bindingi136Nickel 1; via tele nitrogenUniRule annotation1
Metal bindingi217Nickel 1; via carbamate groupUniRule annotation1
Metal bindingi217Nickel 2; via carbamate groupUniRule annotation1
Binding sitei219SubstrateUniRule annotation1
Metal bindingi246Nickel 2; via pros nitrogenUniRule annotation1
Metal bindingi272Nickel 2; via tele nitrogenUniRule annotation1
Active sitei320Proton donorUniRule annotation1
Metal bindingi360Nickel 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotationSAAS annotation, NickelUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370.

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit alphaUniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit alphaUniRule annotation
Gene namesi
Name:ureCUniRule annotation
ORF Names:BGK50_03815Imported
OrganismiShigella sp. FC130Imported
Taxonomic identifieri1892896 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei217N6-carboxylysineUniRule annotation1

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two nickel ions.UniRule annotation

Interactioni

Subunit structurei

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini129 – 567UreaseInterPro annotationAdd BLAST439

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd00375. Urease_alpha. 1 hit.
Gene3Di2.30.40.10. 2 hits.
HAMAPiMF_01953. Urease_alpha. 1 hit.
InterProiView protein in InterPro
IPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
IPR011612. Urease_alpha_N_dom.
IPR017950. Urease_AS.
IPR005848. Urease_asu.
IPR017951. Urease_asu_c.
IPR029754. Urease_Ni-bd.
PANTHERiPTHR43440. PTHR43440. 1 hit.
PfamiView protein in Pfam
PF01979. Amidohydro_1. 1 hit.
PF00449. Urease_alpha. 1 hit.
PRINTSiPR01752. UREASE.
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 2 hits.
TIGRFAMsiTIGR01792. urease_alph. 1 hit.
PROSITEiView protein in PROSITE
PS01120. UREASE_1. 1 hit.
PS00145. UREASE_2. 1 hit.
PS51368. UREASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1D2PZY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTISRQAYA DMFGPTTGDR LRLADTALFL EIEKDFTTYG EEVKFGGGKV
60 70 80 90 100
IRDGMGQSQV VNAECVDVLI TNAIILDHWG IVKADIGIKD GRIVGIGKAG
110 120 130 140 150
NPDVQPNVSI VVGPATEVVA GEGKIVTAGG VDTHIHFICP QQAQEGLVSG
160 170 180 190 200
VTTFIGGGTG PVAGTNATTV TPGIWNMHRM LEAVDELPIN VGLFGKGCVS
210 220 230 240 250
QPEAVREQIE AGAIGLKIHE DWGATPMAIH NCLNVADEMD VQVAIHSDTL
260 270 280 290 300
NEGGFYEETV KAIAGRVIHV FHTEGAGGGH APDVIKSVGE PNILPASTNP
310 320 330 340 350
TMPYTINTVD EHLDMLMVCH HLDPSIPEDV AFAESRIRRE TIAAEDILHD
360 370 380 390 400
MGAISVMSSD SQAMGRVGEV ILRTWQCAHK MKLQRGTLEG DTAESDNHRI
410 420 430 440 450
KRYVAKYTIN PALAHGIAHE VGSIEKGKLA DLVLWDPAFF GVKPALIMKG
460 470 480 490 500
GMVAYAPMGD INAAIPTPQP VHYRPMYACL GKAKYQTSMI FMSKAGIDAG
510 520 530 540 550
VPEKLGLKSL IGRVKGCRTI TKASMIHNSY VPHIELDPQT YIVKADGVPL
560
VCEPATQLPM AQRYFLF
Length:567
Mass (Da):60,851
Last modified:November 30, 2016 - v1
Checksum:i15023337EA170A42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MECU01000022 Genomic DNA. Translation: ODQ06258.1.
RefSeqiWP_069368685.1. NZ_MECU01000022.1.

Similar proteinsi

Entry informationi

Entry nameiA0A1D2PZY5_9ENTR
AccessioniPrimary (citable) accession number: A0A1D2PZY5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2016
Last sequence update: November 30, 2016
Last modified: March 28, 2018
This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported