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Protein

Proteasome subunit alpha

Gene

psmA

Organism
Sulfolobus sp. A20
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Enzyme regulationi

The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine proteaseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alphaUniRule annotation (EC:3.4.25.1UniRule annotation)
Alternative name(s):
20S proteasome alpha subunitUniRule annotation
Proteasome core protein PsmAUniRule annotation
Gene namesi
Name:psmAUniRule annotation
ORF Names:BFU36_02380Imported
OrganismiSulfolobus sp. A20Imported
Taxonomic identifieri1891280 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000094286 Componenti: Chromosome

Subcellular locationi

A0A1C8ZQQ2:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation, ProteasomeUniRule annotationImported

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 32PROTEASOME_ALPHA_1InterPro annotationAdd BLAST23

Sequence similaritiesi

Belongs to the peptidase T1A family.UniRule annotation

Phylogenomic databases

KOiK03432.

Family and domain databases

CDDicd03756. proteasome_alpha_archeal. 1 hit.
Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00289_A. Proteasome_A_A. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR023332. Proteasome_alpha-type.
IPR019982. Proteasome_asu_arc.
IPR000426. Proteasome_asu_N.
IPR001353. Proteasome_sua/b.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
SMARTiView protein in SMART
SM00948. Proteasome_A_N. 1 hit.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR03633. arc_protsome_A. 1 hit.
PROSITEiView protein in PROSITE
PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1C8ZQQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFGPAAMGY DRAITIFSPD GSLYQVDYAF EAVKKGWTAI GLKSKNGVVI
60 70 80 90 100
ASEKRRAQNL LDVDNIEKVF LIDDHVGCSF AGLASDGRVL IDYARNMALQ
110 120 130 140 150
HRLIYDEPIS IDYLTKAVAD VKQMYTQHGG VRPFGVALVI AGIDKSTAKL
160 170 180 190 200
YMTEPSGQFM PYYAVAIGQG YYTATEFLEK NYKEDMSMDE TILLALRALM
210 220 230 240
STLKPNERLT PSTVEIGYAS TQTGVFLKMT NEEKSTYLQK L
Length:241
Mass (Da):26,736
Last modified:November 30, 2016 - v1
Checksum:i4B3441F12E342A8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017006 Genomic DNA. Translation: AOL15760.1.
RefSeqiWP_069281965.1. NZ_CP017006.1.

Genome annotation databases

EnsemblBacteriaiAOL15760; AOL15760; BFU36_02380.
GeneIDi28694669.
KEGGisula:BFU36_02380.

Similar proteinsi

Entry informationi

Entry nameiA0A1C8ZQQ2_9CREN
AccessioniPrimary (citable) accession number: A0A1C8ZQQ2
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2016
Last sequence update: November 30, 2016
Last modified: September 27, 2017
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported