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Protein

DNA topoisomerase

Gene

TOP3B

Organism
Choanephora cucurbitarum
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.UniRule annotation

Catalytic activityi

ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, Isomerase, TopoisomeraseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomeraseUniRule annotation (EC:5.99.1.2UniRule annotation)
Gene namesi
Name:TOP3BImported
ORF Names:A0J61_01796Imported
OrganismiChoanephora cucurbitarumImported
Taxonomic identifieri101091 [NCBI]
Taxonomic lineageiEukaryotaFungiMucoromycotaMucoromycotinaMucoralesMucorineaeChoanephoraceaeChoanephoroideaeChoanephora
Proteomesi
  • UP000093000 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 151ToprimInterPro annotationAdd BLAST147

Sequence similaritiesi

Belongs to the type IA topoisomerase family.UniRule annotation

Family and domain databases

CDDicd00186. TOP1Ac. 1 hit.
cd03362. TOPRIM_TopoIA_TopoIII. 1 hit.
Gene3Di2.70.20.10. 1 hit.
InterProiView protein in InterPro
IPR000380. Topo_IA.
IPR003601. Topo_IA_2.
IPR023406. Topo_IA_AS.
IPR013497. Topo_IA_cen.
IPR013825. Topo_IA_cen_sub2.
IPR023405. Topo_IA_core_domain.
IPR003602. Topo_IA_DNA-bd_dom.
IPR006171. TOPRIM_domain.
IPR034144. TOPRIM_TopoIII.
PANTHERiPTHR11390. PTHR11390. 1 hit.
PfamiView protein in Pfam
PF01131. Topoisom_bac. 1 hit.
PF01751. Toprim. 1 hit.
PRINTSiPR00417. PRTPISMRASEI.
SMARTiView protein in SMART
SM00437. TOP1Ac. 1 hit.
SM00436. TOP1Bc. 1 hit.
SM00493. TOPRIM. 1 hit.
SUPFAMiSSF56712. SSF56712. 1 hit.
PROSITEiView protein in PROSITE
PS00396. TOPOISOMERASE_I_PROK. 1 hit.
PS50880. TOPRIM. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1C7NLX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPHKVLMVA EKPSLAESLS RLLAPDGQFV THKHSTPIHE WKGSFRDEPA
60 70 80 90 100
EFRFTSVTGH VYGLDFTKEY NSWDIDPVKL FEAKTIKLES NPKMRLIHHL
110 120 130 140 150
QSAAKGVDYL VLWLDCDREG ENICFEVIEN CLPSMKHPQN GGKMSHVYRA
160 170 180 190 200
KFSAITKEDV RRAMKNLVRP NEDEARAVDA RQEIDLRTGV SFTRFQTRFF
210 220 230 240 250
QGKYGNLDST VISYGPCQTP TLSFCVERHD RIQGFQPEPF WSVQLTVSKS
260 270 280 290 300
DTPLKLSWGR ERVFDRQIGT MFVNRVSDAK SKGAKVLSIV TQKKSKPRPH
310 320 330 340 350
ALNTVEMLKH SSTGLGMSPS ECMSLAERLY TQGYISYPRT ETSKYPENFD
360 370 380 390 400
LNSVLREQSS HPDWGHYCAD LLANKYDRPS GGTDSGDHPP ITPTRIAYEG
410 420 430 440 450
DLPGNAWRLY DFIVRTFIGS LSSGMKYSTT SVSFEVGGEI FECKGTKLLS
460 470 480 490 500
PGFTSVMHWI TTTDEYIPEF KEGEVLDIQQ VSLVEGKTSP PDYLTEAELI
510 520 530 540
GLMEQHGIGT DASIPTHINN ICQRNYVQVS GTKRYLIPTN LGIVLIHG
Length:548
Mass (Da):61,820
Last modified:November 30, 2016 - v1
Checksum:iDD2C0CCD2B1EF19C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LUGH01000061 Genomic DNA. Translation: OBZ90151.1.

Genome annotation databases

EnsemblFungiiOBZ90151; OBZ90151; A0J61_01796.

Similar proteinsi

Entry informationi

Entry nameiA0A1C7NLX2_9FUNG
AccessioniPrimary (citable) accession number: A0A1C7NLX2
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2016
Last sequence update: November 30, 2016
Last modified: June 7, 2017
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported