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Protein

Thymidine kinase

Gene

tdk

Organism
Geobacillus thermoleovorans (Bacillus thermoleovorans)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Proton acceptorUniRule annotation1
Metal bindingi145ZincUniRule annotation1
Metal bindingi148ZincUniRule annotation1
Metal bindingi183ZincUniRule annotation1
Metal bindingi186ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22ATPUniRule annotation8
Nucleotide bindingi88 – 91ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
ORF Names:A5N86_10930Imported
OrganismiGeobacillus thermoleovorans (Bacillus thermoleovorans)Imported
Taxonomic identifieri33941 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillusGeobacillus thermoleovorans group
Proteomesi
  • UP000094835 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiView protein in Pfam
PF00265. TK. 1 hit.
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00603. TK_CELLULAR_TYPE. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1C3D888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYVMTQSGWL ELICGCMFSG KSEELIRRVR RAQFAKQEVK VFKPTIDNRY
60 70 80 90 100
SEDAVVSHNG NSVIAIPVAT PAEMFRYISA ATDVVAIDEI QFFSDDIIDV
110 120 130 140 150
VQTLADCGYR VIAAGLDQDF RGEPFGPVPA LMAIAESVTK LQAVCTVCGS
160 170 180 190 200
PASRTQRLIN GAPASYDDPV ILVGASEAYE PRCRHHHEVP GKPKKRYNRP

LAGHTGE
Length:207
Mass (Da):22,717
Last modified:January 18, 2017 - v1
Checksum:i8D83B14DA96FB3A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MDCP01000141 Genomic DNA. Translation: ODA17070.1.
RefSeqiWP_014196962.1. NZ_MDCP01000141.1.

Genome annotation databases

GeneIDi32065265.
KEGGigtk:GT3570_16600.

Similar proteinsi

Entry informationi

Entry nameiA0A1C3D888_GEOTH
AccessioniPrimary (citable) accession number: A0A1C3D888
Entry historyiIntegrated into UniProtKB/TrEMBL: January 18, 2017
Last sequence update: January 18, 2017
Last modified: March 28, 2018
This is version 9 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported