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Protein

Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase

Gene

SORBI_3003G071300

Organism
Sorghum bicolor (Sorghum) (Sorghum vulgare)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.UniRule annotation

Catalytic activityi

A very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain trans-2,3-dehydroacyl-CoA + H2O.UniRule annotation

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotation
Biological processFatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydrataseUniRule annotation (EC:4.2.1.134UniRule annotation)
Gene namesi
ORF Names:SORBI_3003G071300Imported
OrganismiSorghum bicolor (Sorghum) (Sorghum vulgare)Imported
Taxonomic identifieri4558 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeSorghinaeSorghum
Proteomesi
  • UP000000768 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 49HelicalUniRule annotationAdd BLAST23
Transmembranei61 – 82HelicalUniRule annotationAdd BLAST22
Transmembranei114 – 134HelicalUniRule annotationAdd BLAST21
Transmembranei146 – 171HelicalUniRule annotationAdd BLAST26

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the very long-chain fatty acids dehydratase HACD family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR007482. Tyr_Pase-like_PTPLA.
PANTHERiPTHR11035. PTHR11035. 1 hit.
PfamiView protein in Pfam
PF04387. PTPLA. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1B6Q1T2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGVPSKKNS SMAGDNGSVV RRLYLSVYNW VSFFGWLLVL YHAILALLGG
60 70 80 90 100
GHEAVYDAVK LPLLFSQTAA LAEILHSITG FVSSPISATL PQVGIRTSVL
110 120 130 140 150
WFIVWRFPET QSHVCLTSLV LSWSITEVIR YPFFGLREAF GITPFWLLWL
160 170 180
RYSTFIVLYP IGLISEVGLI FTAMPHMKVS KPE
Length:183
Mass (Da):20,512
Last modified:November 2, 2016 - v1
Checksum:iE0F3ED5285DC17D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000762 Genomic DNA. Translation: KXG31879.1.

Genome annotation databases

EnsemblPlantsiKXG31879; KXG31879; SORBI_003G071300.
GrameneiKXG31879; KXG31879; SORBI_003G071300.

Similar proteinsi

Entry informationi

Entry nameiA0A1B6Q1T2_SORBI
AccessioniPrimary (citable) accession number: A0A1B6Q1T2
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2016
Last sequence update: November 2, 2016
Last modified: August 30, 2017
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported