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Protein

Peptide deformylase

Gene

def

Organism
Bacillus subtilis subsp. subtilis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotationSAAS annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi110IronUniRule annotation1
Metal bindingi153IronUniRule annotation1
Active sitei154UniRule annotation1
Metal bindingi157IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
Biological processProtein biosynthesisUniRule annotationSAAS annotation
LigandIronUniRule annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylaseUniRule annotationSAAS annotation (EC:3.5.1.88UniRule annotationSAAS annotation)
Short name:
PDFUniRule annotation
Alternative name(s):
Polypeptide deformylaseUniRule annotation
Gene namesi
Name:defUniRule annotation
ORF Names:BEN36_06030Imported, BEP06_05755Imported, BEP07_05760Imported, BH660_08100Imported, S100757_01635Imported
OrganismiBacillus subtilis subsp. subtilisImported
Taxonomic identifieri135461 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000095556 Componenti: Chromosome
  • UP000196400 Componenti: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd00487 Pep_deformylase, 1 hit
Gene3Di3.90.45.101 hit
HAMAPiMF_00163 Pep_deformylase, 1 hit
InterProiView protein in InterPro
IPR023635 Peptide_deformylase
IPR036821 Peptide_deformylase_sf
PANTHERiPTHR10458 PTHR10458, 1 hit
PfamiView protein in Pfam
PF01327 Pep_deformylase, 1 hit
PIRSFiPIRSF004749 Pep_def, 1 hit
PRINTSiPR01576 PDEFORMYLASE
SUPFAMiSSF56420 SSF56420, 1 hit
TIGRFAMsiTIGR00079 pept_deformyl, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1B2BBH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITMENIVRD GHPALRETAE PVELPPTDAE KQQLADMIEF VKNSQNPELA
60 70 80 90 100
EKYKLRPGVG LAAPQINIKK RMIAVHAEDA SGKLYSYALF NPKIVSHSVE
110 120 130 140 150
KSYLTSGEGC LSVDEAIPGY VPRYARIRVK GTTLEGENID IRLKGFPAIV
160 170 180
FQHEIDHLNG VMFYDHIDKE NPFKEPENAI AIER
Length:184
Mass (Da):20,656
Last modified:November 2, 2016 - v1
Checksum:i8641BF1932666C38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP016787 Genomic DNA Translation: ANY32100.1
CP016788 Genomic DNA Translation: ANY34949.1
CP016789 Genomic DNA Translation: ANY37703.1
CP017313 Genomic DNA Translation: AOT51931.1
CP021499 Genomic DNA Translation: ARW02566.1
RefSeqiWP_003245474.1, NZ_LVYH01000011.1

Genome annotation databases

EnsemblBacteriaiAOT51931; AOT51931; BH660_08100
PATRICifig|135461.10.peg.83

Similar proteinsi

Entry informationi

Entry nameiA0A1B2BBH2_BACIU
AccessioniPrimary (citable) accession number: A0A1B2BBH2
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2016
Last sequence update: November 2, 2016
Last modified: April 25, 2018
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported