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Protein

Isocitrate dehydrogenase [NADP]

Gene

PA27867_2865

Organism
Cryobacterium arcticum
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg2+ or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei77SubstrateUniRule annotation1
Binding sitei82NADPUniRule annotation1
Binding sitei109SubstrateUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Sitei139Critical for catalysisUniRule annotation1
Sitei211Critical for catalysisUniRule annotation1
Metal bindingi251Magnesium or manganeseUniRule annotation1
Binding sitei259NADPUniRule annotation1
Metal bindingi274Magnesium or manganeseUniRule annotation1
Binding sitei327NADP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi75 – 77NADPUniRule annotation3
Nucleotide bindingi309 – 314NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processTricarboxylic acid cycleUniRule annotation
LigandMagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:PA27867_2865Imported
OrganismiCryobacterium arcticumImported
Taxonomic identifieri670052 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrobacteriaceaeCryobacterium
Proteomesi
  • UP000092582 Componenti: Chromosome 1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 395Iso_dhInterPro annotationAdd BLAST387

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni94 – 100Substrate bindingUniRule annotation7

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

InterProiView protein in InterPro
IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiView protein in Pfam
PF00180. Iso_dh. 1 hit.
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
SMARTiView protein in SMART
SM01329. Iso_dh. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiView protein in PROSITE
PS00470. IDH_IMDH. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1B1BN76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKIKVAGTV VELDGDEMTR IIWQAIKDSL IHPYLDIDLE YYDLSIQKRD
60 70 80 90 100
ETDDQITIDA AHAIQKHGVG VKCATITPDE ARVEEFGLKK MWASPNGTIR
110 120 130 140 150
NILGGTIFRE PIIISNIPRL VPGWNKPIII GRHAFGDQYR ATNFRFEGEG
160 170 180 190 200
TLTMTFTPKD GGDPQQFEVF QAPGSGVAMG MYNLDKSIID FARASLNYGL
210 220 230 240 250
ERNYPVYLST KNTILKAYDG RFKDIFQEIF DTEFKDRFEA AGLTYEHRLI
260 270 280 290 300
DDMVASAMKW EGGYVWACKN YDGDVQSDTV AQGFGSLGLM TSVLSTPDGS
310 320 330 340 350
VVEAEAAHGT VTRHYRQHQQ GKPTSTNPIA SIYAWTRGLS HRAKLDSNPA
360 370 380 390 400
LAEFAHTLED VVVKTVESGK MTKDLALLVG PDQGYLTTEE FLAAISDNLQ

TRLA
Length:404
Mass (Da):44,905
Last modified:November 2, 2016 - v1
Checksum:iAF796F3F7F7371FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP016282 Genomic DNA. Translation: ANP73803.1.
RefSeqiWP_066597465.1. NZ_CP016282.1.

Genome annotation databases

EnsemblBacteriaiANP73803; ANP73803; PA27867_2865.
KEGGicart:PA27867_2865.
PATRICifig|670052.7.peg.2943.

Similar proteinsi

Entry informationi

Entry nameiA0A1B1BN76_9MICO
AccessioniPrimary (citable) accession number: A0A1B1BN76
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2016
Last sequence update: November 2, 2016
Last modified: June 7, 2017
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported