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Protein

Voltage-dependent L-type calcium channel subunit alpha

Gene

CACNA1D

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. Binding of calmodulin or CABP1 at the same regulatory sites results in opposite effects on the channel function.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alphaUniRule annotation
Gene namesi
Name:CACNA1DImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:1391 CACNA1D

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 41HelicalSequence analysisAdd BLAST22
Transmembranei97 – 118HelicalSequence analysisAdd BLAST22
Transmembranei130 – 152HelicalSequence analysisAdd BLAST23
Transmembranei290 – 308HelicalSequence analysisAdd BLAST19
Transmembranei328 – 351HelicalSequence analysisAdd BLAST24
Transmembranei420 – 439HelicalSequence analysisAdd BLAST20
Transmembranei492 – 519HelicalSequence analysisAdd BLAST28
Transmembranei654 – 672HelicalSequence analysisAdd BLAST19
Transmembranei692 – 712HelicalSequence analysisAdd BLAST21
Transmembranei724 – 750HelicalSequence analysisAdd BLAST27
Transmembranei770 – 800HelicalSequence analysisAdd BLAST31
Transmembranei895 – 922HelicalSequence analysisAdd BLAST28
Transmembranei974 – 994HelicalSequence analysisAdd BLAST21
Transmembranei1006 – 1025HelicalSequence analysisAdd BLAST20
Transmembranei1116 – 1139HelicalSequence analysisAdd BLAST24
Transmembranei1207 – 1231HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000157388

PTM / Processingi

Proteomic databases

PeptideAtlasiA0A1B0GWE1

Expressioni

Gene expression databases

ExpressionAtlasiA0A1B0GWE1 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 163Ion_transInterPro annotationAdd BLAST162
Domaini291 – 526Ion_transInterPro annotationAdd BLAST236
Domaini652 – 929Ion_transInterPro annotationAdd BLAST278
Domaini972 – 1241Ion_transInterPro annotationAdd BLAST270
Domaini1243 – 1313GPHHInterPro annotationAdd BLAST71
Domaini1314 – 1364Ca_chan_IQInterPro annotationAdd BLAST51

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili522 – 553Sequence analysisAdd BLAST32
Coiled coili1326 – 1346Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00830000128247

Family and domain databases

Gene3Di1.20.120.350, 3 hits
InterProiView protein in InterPro
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR005452 LVDCC_a1dsu
IPR014873 VDCC_a1su_IQ
IPR005446 VDCC_L_a1su
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF139 PTHR10037:SF139, 1 hit
PfamiView protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 4 hits
PRINTSiPR00167 CACHANNEL
PR01630 LVDCCALPHA1
PR01636 LVDCCALPHA1D

Sequencei

Sequence statusi: Fragment.

A0A1B0GWE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
XPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF IGKMHKTCFF
60 70 80 90 100
ADSDIVAEED PAPCAFSGNG RQCTANGTEC RSGWVGPNGG ITNFDNFAFA
110 120 130 140 150
MLTVFQCITM EGWTDVLYWV NDAIGWEWPW VYFVSLIILG SFFVLNLVLG
160 170 180 190 200
VLSGEFSKER EKAKARGDFQ KLREKQQLEE DLKGYLDWIT QAEDIDPENE
210 220 230 240 250
EEGGEEGKRN TSMPTSETES VNTENVSGEG ENRGCCGSLW CWWRRRGAAK
260 270 280 290 300
AGPSGCRRWG QAISKSKLSR RWRRWNRFNR RRCRAAVKSV TFYWLVIVLV
310 320 330 340 350
FLNTLTISSE HYNQPDWLTQ IQDIANKVLL ALFTCEMLVK MYSLGLQAYF
360 370 380 390 400
VSLFNRFDCF VVCGGITETI LVELEIMSPL GISVFRCVRL LRIFKVTRHW
410 420 430 440 450
TSLSNLVASL LNSMKSIASL LLLLFLFIII FSLLGMQLFG GKFNFDETQT
460 470 480 490 500
KRSTFDNFPQ ALLTVFQILT GEDWNAVMYD GIMAYGGPSS SGMIVCIYFI
510 520 530 540 550
ILFICGNYIL LNVFLAIAVD NLADAESLNT AQKEEAEEKE RKKIARKESL
560 570 580 590 600
ENKKNNKPEV NQIANSDNKV TIDDYREEDE DKDPYPPCDV PVGEEEEEEE
610 620 630 640 650
EDEPEVPAGP RPRRISELNM KEKIAPIPEG SAFFILSKTN PIRVGCHKLI
660 670 680 690 700
NHHIFTNLIL VFIMLSSAAL AAEDPIRSHS FRNTILGYFD YAFTAIFTVE
710 720 730 740 750
ILLKMTTFGA FLHKGAFCRN YFNLLDMLVV GVSLVSFGIQ SSAISVVKIL
760 770 780 790 800
RVLRVLRPLR AINRAKGLKH VVQCVFVAIR TIGNIMIVTT LLQFMFACIG
810 820 830 840 850
VQLFKGKFYR CTDEAKSNPE ECRGLFILYK DGDVDSPVVR ERIWQNSDFN
860 870 880 890 900
FDNVLSAMMA LFTVSTFEGW PALLYKAIDS NGENIGPIYN HRVEISIFFI
910 920 930 940 950
IYIIIVAFFM MNIFVGFVIV TFQEQGEKEY KNCELDKNQR QCVEYALKAR
960 970 980 990 1000
PLRRYIPKNP YQYKFWYVVN SSPFEYMMFV LIMLNTLCLA MQHYEQSKMF
1010 1020 1030 1040 1050
NDAMDILNMV FTGVFTVEMV LKVIAFKPKH YFTDAWNTFD ALIVVGSVVD
1060 1070 1080 1090 1100
IAITEVNPTE SENVPVPTAT PGNSEESNRI SITFFRLFRV MRLVKLLSRG
1110 1120 1130 1140 1150
EGIRTLLWTF IKSFQALPYV ALLIAMLFFI YAVIGMQMFG KVAMRDNNQI
1160 1170 1180 1190 1200
NRNNNFQTFP QAVLLLFRCA TGEAWQEIML ACLPGKLCDP ESDYNPGEEY
1210 1220 1230 1240 1250
TCGSNFAIVY FISFYMLCAF LIINLFVAVI MDNFDYLTRD WSILGPHHLD
1260 1270 1280 1290 1300
EFKRIWSEYD PEAKGRIKHL DVVTLLRRIQ PPLGFGKLCP HRVACKRLVA
1310 1320 1330 1340 1350
MNMPLNSDGT VMFNATLFAL VRTALKIKTE GNLEQANEEL RAVIKKIWKK
1360 1370
TSMKLLDQVV PPAGGQCSLF PK
Length:1,372
Mass (Da):156,371
Last modified:October 5, 2016 - v1
Checksum:iB94F1F3F9B16FFC8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005905 Genomic DNA No translation available.
AC012467 Genomic DNA No translation available.
AC024149 Genomic DNA No translation available.
AC092035 Genomic DNA No translation available.
AC112218 Genomic DNA No translation available.
AC132810 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000636627; ENSP00000490889; ENSG00000157388

Similar proteinsi

Entry informationi

Entry nameiA0A1B0GWE1_HUMAN
AccessioniPrimary (citable) accession number: A0A1B0GWE1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2016
Last sequence update: October 5, 2016
Last modified: May 23, 2018
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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