Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Voltage-dependent L-type calcium channel subunit alpha

Gene

CACNA1D

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. Binding of calmodulin or CABP1 at the same regulatory sites results in opposite effects on the channel function.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alphaUniRule annotation
Gene namesi
Name:CACNA1DImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:1391 CACNA1D

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei130 – 147HelicalSequence analysisAdd BLAST18
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei199 – 218HelicalSequence analysisAdd BLAST20
Transmembranei271 – 294HelicalSequence analysisAdd BLAST24
Transmembranei350 – 371HelicalSequence analysisAdd BLAST22
Transmembranei383 – 405HelicalSequence analysisAdd BLAST23
Transmembranei523 – 541HelicalSequence analysisAdd BLAST19
Transmembranei561 – 584HelicalSequence analysisAdd BLAST24
Transmembranei653 – 672HelicalSequence analysisAdd BLAST20
Transmembranei725 – 752HelicalSequence analysisAdd BLAST28
Transmembranei887 – 905HelicalSequence analysisAdd BLAST19
Transmembranei925 – 945HelicalSequence analysisAdd BLAST21
Transmembranei957 – 983HelicalSequence analysisAdd BLAST27
Transmembranei1003 – 1033HelicalSequence analysisAdd BLAST31
Transmembranei1128 – 1155HelicalSequence analysisAdd BLAST28
Transmembranei1207 – 1227HelicalSequence analysisAdd BLAST21
Transmembranei1239 – 1258HelicalSequence analysisAdd BLAST20
Transmembranei1349 – 1372HelicalSequence analysisAdd BLAST24
Transmembranei1440 – 1464HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000157388

PTM / Processingi

Proteomic databases

PeptideAtlasiA0A1B0GUB6

Expressioni

Gene expression databases

ExpressionAtlasiA0A1B0GUB6 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1598 – 1632Ca_chan_IQInterPro annotationAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili755 – 786Sequence analysisAdd BLAST32
Coiled coili1559 – 1579Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00830000128247

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR005452 LVDCC_a1dsu
IPR014873 VDCC_a1su_IQ
IPR005446 VDCC_L_a1su
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF139 PTHR10037:SF139, 1 hit
PfamiView protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 4 hits
PRINTSiPR00167 CACHANNEL
PR01630 LVDCCALPHA1
PR01636 LVDCCALPHA1D
SMARTiView protein in SMART
SM01062 Ca_chan_IQ, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1B0GUB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMMMMMMKKM QHQRQQQADH ANEANYARGT RLPLSGEGPT SQPNSSKQTV
60 70 80 90 100
LSWQAAIDAA RQAKAAQTMS TSAPPPVGSL SQRKRQQYAK SKKQGNSSNS
110 120 130 140 150
RPARALFCLS LNNPIRRACI SIVEWKPFDI FILLAIFANC VALAIYIPFP
160 170 180 190 200
EDDSNSTNHN LEKVEYAFLI IFTVETFLKI IAYGLLLHPN AYVRNGWNLL
210 220 230 240 250
DFVIVIVGLF SVILEQLTKE TEGGNHSSGK SGGFDVKALR AFRVLRPLRL
260 270 280 290 300
VSGVPSLQVV LNSIIKAMVP LLHIALLVLF VIIIYAIIGL ELFIGKMHKT
310 320 330 340 350
CFFADSDIVA EEDPAPCAFS GNGRQCTANG TECRSGWVGP NGGITNFDNF
360 370 380 390 400
AFAMLTVFQC ITMEGWTDVL YWVNDAIGWE WPWVYFVSLI ILGSFFVLNL
410 420 430 440 450
VLGVLSGEFS KEREKAKARG DFQKLREKQQ LEEDLKGYLD WITQAEDIDP
460 470 480 490 500
ENEEEGGEEG KRNTSMPTSE TESVNTENVS GEGENRGCCG SLCQAISKSK
510 520 530 540 550
LSRRWRRWNR FNRRRCRAAV KSVTFYWLVI VLVFLNTLTI SSEHYNQPDW
560 570 580 590 600
LTQIQDIANK VLLALFTCEM LVKMYSLGLQ AYFVSLFNRF DCFVVCGGIT
610 620 630 640 650
ETILVELEIM SPLGISVFRC VRLLRIFKVT RHWTSLSNLV ASLLNSMKSI
660 670 680 690 700
ASLLLLLFLF IIIFSLLGMQ LFGGKFNFDE TQTKRSTFDN FPQALLTVFQ
710 720 730 740 750
ILTGEDWNAV MYDGIMAYGG PSSSGMIVCI YFIILFICGN YILLNVFLAI
760 770 780 790 800
AVDNLADAES LNTAQKEEAE EKERKKIARK ESLENKKNNK PEVNQIANSD
810 820 830 840 850
NKVTIDDYRE EDEDKDPYPP CDVPVGEEEE EEEEDEPEVP AGPRPRRISE
860 870 880 890 900
LNMKEKIAPI PEGSAFFILS KTNPIRVGCH KLINHHIFTN LILVFIMLSS
910 920 930 940 950
AALAAEDPIR SHSFRNTILG YFDYAFTAIF TVEILLKMTT FGAFLHKGAF
960 970 980 990 1000
CRNYFNLLDM LVVGVSLVSF GIQSSAISVV KILRVLRVLR PLRAINRAKG
1010 1020 1030 1040 1050
LKHVVQCVFV AIRTIGNIMI VTTLLQFMFA CIGVQLFKGK FYRCTDEAKS
1060 1070 1080 1090 1100
NPEECRGLFI LYKDGDVDSP VVRERIWQNS DFNFDNVLSA MMALFTVSTF
1110 1120 1130 1140 1150
EGWPALLYKA IDSNGENIGP IYNHRVEISI FFIIYIIIVA FFMMNIFVGF
1160 1170 1180 1190 1200
VIVTFQEQGE KEYKNCELDK NQRQCVEYAL KARPLRRYIP KNPYQYKFWY
1210 1220 1230 1240 1250
VVNSSPFEYM MFVLIMLNTL CLAMQHYEQS KMFNDAMDIL NMVFTGVFTV
1260 1270 1280 1290 1300
EMVLKVIAFK PKGYFSDAWN TFDSLIVIGS IIDVALSEAD PTESENVPVP
1310 1320 1330 1340 1350
TATPGNSEES NRISITFFRL FRVMRLVKLL SRGEGIRTLL WTFIKSFQAL
1360 1370 1380 1390 1400
PYVALLIAML FFIYAVIGMQ MFGKVAMRDN NQINRNNNFQ TFPQAVLLLF
1410 1420 1430 1440 1450
RCATGEAWQE IMLACLPGKL CDPESDYNPG EEYTCGSNFA IVYFISFYML
1460 1470 1480 1490 1500
CAFLIINLFV AVIMDNFDYL TRDWSILGPH HLDEFKRIWS EYDPEAKGRI
1510 1520 1530 1540 1550
KHLDVVTLLR RIQPPLGFGK LCPHRVACKR LVAMNMPLNS DGTVMFNATL
1560 1570 1580 1590 1600
FALVRTALKI KTEGNLEQAN EELRAVIKKI WKKTSMKLLD QVVPPAGDDE
1610 1620 1630 1640
VTVGKFYATF LIQDYFRKFK KRKEQGLVGK YPAKNTTIAL QMLERML
Length:1,647
Mass (Da):187,077
Last modified:October 5, 2016 - v1
Checksum:i5F5CC33C32B0A4A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005905 Genomic DNA No translation available.
AC012467 Genomic DNA No translation available.
AC024149 Genomic DNA No translation available.
AC092035 Genomic DNA No translation available.
AC112218 Genomic DNA No translation available.
AC132810 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000636938; ENSP00000490039; ENSG00000157388

Similar proteinsi

Entry informationi

Entry nameiA0A1B0GUB6_HUMAN
AccessioniPrimary (citable) accession number: A0A1B0GUB6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2016
Last sequence update: October 5, 2016
Last modified: May 23, 2018
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health