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Protein
Submitted name:

Voltage-dependent L-type calcium channel subunit alpha-1D

Gene

CACNA1D

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Submitted name:
Voltage-dependent L-type calcium channel subunit alpha-1DImported
Gene namesi
Name:CACNA1DImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:1391 CACNA1D

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei67 – 85HelicalSequence analysisAdd BLAST19
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Transmembranei192 – 210HelicalSequence analysisAdd BLAST19
Transmembranei284 – 307HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000157388

PTM / Processingi

Proteomic databases

PeptideAtlasiA0A1B0GTP8

Expressioni

Gene expression databases

ExpressionAtlasiA0A1B0GTP8 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini441 – 475Ca_chan_IQInterPro annotationAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili402 – 422Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00830000128247

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR005452 LVDCC_a1dsu
IPR014873 VDCC_a1su_IQ
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF139 PTHR10037:SF139, 1 hit
PfamiView protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00167 CACHANNEL
SMARTiView protein in SMART
SM01062 Ca_chan_IQ, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1B0GTP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNIFVGFVI VTFQEQGEKE YKNCELDKNQ RQCVEYALKA RPLRRYIPKN
60 70 80 90 100
PYQYKFWYVV NSSPFEYMMF VLIMLNTLCL AMQHYEQSKM FNDAMDILNM
110 120 130 140 150
VFTGVFTVEM VLKVIAFKPK GYFSDAWNTF DSLIVIGSII DVALSEADNS
160 170 180 190 200
EESNRISITF FRLFRVMRLV KLLSRGEGIR TLLWTFIKSF QALPYVALLI
210 220 230 240 250
AMLFFIYAVI GMQMFGKVAM RDNNQINRNN NFQTFPQAVL LLFRCATGEA
260 270 280 290 300
WQEIMLACLP GKLCDPESDY NPGEEYTCGS NFAIVYFISF YMLCAFLIIN
310 320 330 340 350
LFVAVIMDNF DYLTRDWSIL GPHHLDEFKR IWSEYDPEAK GRIKHLDVVT
360 370 380 390 400
LLRRIQPPLG FGKLCPHRVA CKRLVAMNMP LNSDGTVMFN ATLFALVRTA
410 420 430 440 450
LKIKTEGNLE QANEELRAVI KKIWKKTSMK LLDQVVPPAG DDEVTVGKFY
460 470 480 490
ATFLIQDYFR KFKKRKEQGL VGKYPAKNTT IALQMLERML
Length:490
Mass (Da):56,848
Last modified:October 5, 2016 - v1
Checksum:i308EBADDD1FD0499
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005905 Genomic DNA No translation available.
AC012467 Genomic DNA No translation available.
AC024149 Genomic DNA No translation available.
AC092035 Genomic DNA No translation available.
AC112218 Genomic DNA No translation available.
AC132810 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000638120; ENSP00000489790; ENSG00000157388

Similar proteinsi

Entry informationi

Entry nameiA0A1B0GTP8_HUMAN
AccessioniPrimary (citable) accession number: A0A1B0GTP8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2016
Last sequence update: October 5, 2016
Last modified: March 28, 2018
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health